Thread by @LindaWhaley

Good Morning! Day 2 of #LowCarbSeattle will start soon. Today I will have individual threads for the presentations. Speakers today are @DrAseemMalhotra , @tednaiman , @obesityresolved , @LDLSkeptic , and @DaveKeto . Totally enjoying the conference. Thank you @lowcarbusa !

Today's talks: @DrAseemMalhotra Public Health Advocacy; @TedNaiman Macros & Metab; @obesityresolved Obesity Understood, Obesity Resolved; @LDLSkeptic LDL & LCHF; @DaveKeto A Deep Dive into Cholesterol & Risk.

@DrAseemMalhotra @tednaiman @ObesityResolved @LDLSkeptic @DaveKeto First up .@DrAseemMalhotra is having to present via Skype or similar. A bit of connectivity issues, but better now.

Obesity on the rise in UK. Ease of access to ultra processed foods feed problem. Hospitals allow junk food on their campus.

He wrote an article and spoke at a conference on removing junk food from hospitals. A NHS hospital removed it from their campus.

Half of UK family food is ultra processed.

More difficulties with delivery of presentation.

Some members of society have less access to nutrition info to understand issues.

Correction - he spoke to Parliment, not at a conference.

Trying to reconnect on Skype.

Mention Dr. Yudkin's book "Pure White & Deadly"

Fructose is not Glucose

Sorry, can't hear too well. Lost connection.

Unfortunately @DrAseemMalhotra 's talk has been cancelled for now. He will record his talk and make it available to @lowcarbusa who will make it available to us - probably after this conference. They both tried really hard to make this talk happen and we are grateful for this.

@DrAseemMalhotra @lowcarbusa Someone just suggested folks share their personal stories and we have a wonderful woman sharing her story. She had scary high labs, family history of diabetes & stroke.

@DrAseemMalhotra @lowcarbusa She eventually ended up on Keto with the support of her family, but had trouble understanding what it was all about but preservered and has lost 80 pounds and labs improved wonderfully.

Caroline is sharing her story - she lost 200 pounds. Endocrine disorder, PCOS, normal A1c, Docs had no help. Saw a naturopath and insulin was 70. Started lowcarb, cycle started for first time ever, lost weight, got pregnant with twins. Her story is on @DietDoctor1 website.

@DietDoctor1 A man is sharing. He became a psychotherapist & noticed the patients at the local hospital he interned with were obese & ended up working with local bariatric surgeons. Eventually partnered with someone to start a non-surgical medical/behavioral practice focused on Keto.

@DietDoctor1 A woman from India with a history of medical issues over many years. She went from pre-diabetic to T2D and finally found @DietDoctor1 , worked with @meganjramos , and has improved her health. She wants to inform and motivate others.

@DietDoctor1 @meganjramos Daniel Schulof is speaking now. He has written a book on how these health issues affect pets: "Dogs, Dog Food, & Dogma" He says there is not much info on this topic in the animal care and food world.

@DietDoctor1 @meganjramos Michael Wood, who helped organize #LowCarbSeattle is talking about how his dentist suggested changing his diet based on his oral health. Dentist suggested "Good Calories, Bad Calories". He went keto, lost weight, improved A1c, wants to give back.

@DietDoctor1 @meganjramos These were all great stories. We have a brief break and then .@TedNaiman is up. I will be tweeting that separately from this thread, but will start it as a reply from my second post of this thread. Hope this works! I am learning as I go. :-)

@DrAseemMalhotra @tednaiman @ObesityResolved @LDLSkeptic @DaveKeto Time for the 2nd talk of Day 2 #LowCarb Seattle. .@tednaiman will be talking on Macronutrients & Metabolism.

@DrAseemMalhotra @tednaiman @ObesityResolved @LDLSkeptic @DaveKeto And yes, he has a shirt on. :-)

Starting at a basic level - plants make their own food, animals have to eat food. Animals eat plants. Basic. Now jumping into Carbon, Hydrogen, & Oxygen from the air & water, nitrogen from the soil. Getting into sciency carbon carbon bonds.

Plants use soil nitrogen to make amino acids. Air & water help them make fats. All this go to herbivores/carnivores. New application of his P:E concept. You will need to see the slides.

Carnivores have highest P:E like @SBakerMD ;-)

From paleo times to now we figured how to use technology to feed ourselves, but went too far & have destroyed our diets with processing.

Pro/Carb/Fat

Carbs+Fat = weight gain

Carbs break down to glucose.

Mentioned Jean-Pierre Flatt PHD Human Energy Metabolism came up with hydrolic 2 compartment model.

Ted now explaining his 2 compartment model (see on his Twitter feed).

Olive oil similar to fat in liver, potato starch similar to liver glycogen. Glucose is go energy for quick use.

Glycogen in muscles only for use in emergency unless heavy workouts, liver holds a lot more.

Randle cycle - competition between Glucose & Fat. Glucose controls what you are oxidizing.

Carbs spare fat oxidation.

HCLF vegan has more glu fluctuation, probably bad for teeth, mood, but will be thin.

LCHF - fat adapted, can fast, level BG, good dental.

HCHF - BAD

Obesity Settling Point - insufficient rate of fatty acid oxidation. Hope I got that right.

When obese eat carbs the shut off of oxidation is incredibly higher than thin people.

Liver most imp metab organ. Makes all glucose. Shows slide he says is needlesly complicated. :-)

Expects everyone to memorize next complicated slide. I am loving this talk! :-)

Liver stress/strain curve looks like something mechanical, uses dynamic/kenetic to describe.

Be sure to see all these slides. Talking Fed to Fasted with good slide.

Liver glycogen falls after eating until you eat carbs again. Liver makes glucose even if you don't eat glucose through GNG from glycerol, amino acids, & lactate.

SAD 100g Pro, 100g Fat, 300g Carbs.

Glucose falls you get hungry.

Glycogen in muscles - light ex, none, heavy lots

Deplete glycogen your fat oxidation increases. Talking about high intensity exercise and glycogen depletion; can trade intensity for duration to remove glycogen from muscles.

Ted favors carb restriction and high intensity.

Carbs are to preserve body fat evolutionarily.

Eating fat gets stored in adipocytes. Good if high fat oxidation, otherwise get fatter. Shows IR diagram to show fat storage getting larger.

When fat cells are full Trg & Glu have nowhere to go = T2D.

To better oxidize fat = eat less carbs. Even more exercise & eat less carbs.

Fat loss = fat ox - fat intake.

If you eat mostly energy, you will be mostly energy. If you eat mostly protein, you will be mostly protein. End. Q&A up.

Q&A .@tednaiman
- high intensity ex might need carb loading for muscles, not others. Liver gly diff muscle gly
- In geriatric setting use super simple body weight ex, squats from chair, wall pushups, walk up a hill quick. Target quads w/ squats

@tednaiman - don't know enough about carnivore diet, but doesn't want to take it to religious level. Nose to tail makes sense.
- body making glucose out of something. Obese can make glu from glycerol. Thin need glu - body makes from pro and will take from muscles. Eat pro & lift

@tednaiman - TOFI - no difference with Fat, except look better.
- HF/HC/High energy density = Fat.
- Pro turning into glu is demand driven not supply driven. T1D could be exception.
- Alcohol makes food load into AT until alcohol burned off. Alcohol is toxic.

@tednaiman - Liver glycogen low w/ no carbs. Muscles will fill with glycogen no matter carbs or not.
- Pro leverage/quality you eat more until you get enough pro, plant protein not as easy to use.
- GNG glucocorticoids w/ SAD diets w/ high cortisol. Get off steroid if on. Eat less fat.

@tednaiman - T1D dose for Pro. Does not see BG inc with Pro in other patients. Can't explain those who are seeing it. More fat = satiety. Those who are losing w/ more fat depends on activity level. Exercise more if liking more fat.
- Fat ox = breaking carbon/carbon bonds by mitochondria

@tednaiman - No rec for folks w/o pituitary. Can replace things pituitary doesn't make.
- Q: Heavy metal exposure effect on obesity? Not sure he believes that.
- Hard to get Fat adapted, but keep at it as metabolic exercise. Try getting 1% better each day.
- Competitive level ex need carbs

@DietDoctor1 @meganjramos @tednaiman .@threadreaderapp unroll please

@tednaiman - Fasting pro/mtor Q. Ted does not recommend longer than 24hrs.
- Glycogen depletion is beneficial for NAFLD
- Low/ZC and too much fat in diet will gain weight and get fat stored in liver.

End Q&A Thank you @tednaiman for a great session!!!

@DrAseemMalhotra @tednaiman @ObesityResolved @LDLSkeptic @DaveKeto 3rd Talk of today @ObesityResolved

Measurables in term of health should be our BG.

Dr Cywes used to weigh 300#.

Obesity is not a nutritional problem, it is a mental health problem.

Carbs- Food or Drugs?

Mentions "Never in Anger' by Jean L. Briggs on Inuits

@DrAseemMalhotra @tednaiman @ObesityResolved @LDLSkeptic @DaveKeto Inuits live in harsh environment but learn kindness from very young.

Humans work like a car engine. We need a cooling system to balance heat. Heat in humans = stress. Cooling = meditation, arts, emotion management. Heat w/o cooling = develop mental health disease.

@DrAseemMalhotra @tednaiman @ObesityResolved @LDLSkeptic @DaveKeto Lipid Heart Hypothesis - Ancel Keyes, then we started avoiding Sat Fat.

CIMOD Carbohydrate Insulin Mechanism of Obesity & Diabetes.

Snacking is emotional event and not nutrition event.

Carbs manage emotional needs not nutrition needs.

Obesity & T2D is a choice not a disease.

@DrAseemMalhotra @tednaiman @ObesityResolved @LDLSkeptic @DaveKeto Carbs easy to store as food. Seasonally available.

Carbs as Drugs not essential. Carbs give endorphin feedback. Excess leads to harm. Oblivious to risk.

Impossible to get fat from eating food. Will return to this statement.

@DrAseemMalhotra @tednaiman @ObesityResolved @LDLSkeptic @DaveKeto Homeostasis prevents harm. Satiety feedback triggers hormones to stop eating. Therefore you can't get fat from eating food. But when eating food as drugs, then you can gain weight.

Feedback mechanisms control body. No feedback for carbs so developed calories.

@DrAseemMalhotra @tednaiman @ObesityResolved @LDLSkeptic @DaveKeto Bariatric surgery is portion control. Effective short term.

Fatty liver suppress leptin. Leptin gives satiation response to high fat meal.

Carb+Fat blocks leptin response from fat.

Fattest people w/o T2D can be healthy w/ lower insulin. Once IR A1c rises.

@DrAseemMalhotra @tednaiman @ObesityResolved @LDLSkeptic @DaveKeto On keto needs 2-3 months for fat adaptation.

Protein not used for body repair, or other function, gets stored as fat.

Eat LCHF and allow your body to say when you are hungry. Frequent little bits of exercise work important.

Liver starts GNG in anticipation of need.

@DrAseemMalhotra @tednaiman @ObesityResolved @LDLSkeptic @DaveKeto Obesity like a polluted river. Need to shut down factories putting pollution in river.

1. Own problem.
2. Contemplate how big problem is.
- # Carbs, Freq, Why?
3. Change. Takes time, one bit at a time. Remove & replace.
- remove carb drinks & replace with ZC drinks

@DrAseemMalhotra @tednaiman @ObesityResolved @LDLSkeptic @DaveKeto - No calories from drinks.
- Meal = plate w/ knife & fork
- Human brain needs break every 20-30 minutes.
- Salt, salt, salt
4. Remove vehicle foods and lookalikes.
5. No snacks - do nice action instead
6. No fruit incl fruit. Can have tomatoes, olives & avocados.

@DrAseemMalhotra @tednaiman @ObesityResolved @LDLSkeptic @DaveKeto Fat Change stages
1. ZC, add fat. Protein irrelevent
2. Eat smaller portions and get more if needed until satiety.
3. IF
4. Physical activity.

Live Whole Heartedly.

Interesting talk. Thank you @ObesityResolved

@DrAseemMalhotra @tednaiman @ObesityResolved @LDLSkeptic @DaveKeto .@threadreaderapp unroll please

@tednaiman .@threadreaderapp unroll please