Another Paper: Here we found that treating the patients diagnosed as novel coronavirus pneumonia with chloroquine might improve the success rate of treatment, shorten hospital stay and improve patient outcome.
ncbi.nlm.nih.gov/pubmed/3207536…
ncbi.nlm.nih.gov/pubmed/3207536…
It recommended chloroquine phosphate tablet, 500mg twice per day for 10 days for patients diagnosed as mild, moderate and severe cases of novel coronavirus pneumonia and without contraindications to chloroquine.
Previous research has shown that chloroquine exerts antiviral effects through different mechanisms. Because chloroquine can change the pH value of endosomes, it has a significant inhibitory effect on viral infections that invade cells through the endosome pathway
The results of the University of Leuven University in Belgium show that chloroquine phosphate can inhibit virus replication in Vero E6 cell line induced by SARS-CoV, with a 50% inhibitory concentration
A study by the US CDC further clarified that chloroquine inhibits virus replication by reducing terminal glycosylation of angiotensin-converting enzyme 2 (ACE2) receptors on the surface of Vero E6 cells and interfering with the binding of SARS-CoV and ACE2 receptors Function
Chloroquine also has inhibitory effects on α-group HCoVs, such as HCoV-229E. Chiba University of Japan team found that chloroquine inhibited the replication of HCoV-229E on L132 human embryonic lung cell line by inhibiting p38 mitogen-activated protein kinase (MAPK) activation
The medication should be used under the guidance of a specialist.
The blood routine should be monitored every other day during the medication.
Before the treatment, perform an electrocardiogram routinely. Observe patient vision and mental state
The blood routine should be monitored every other day during the medication.
Before the treatment, perform an electrocardiogram routinely. Observe patient vision and mental state
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