Discover and read the best of Twitter Threads about #placebo

Most recents (23)

Globuli ab Geburt: Im neuen @derspiegel berichte ich, wie junge Eltern (und Kinder) zur #Homöopathie getrieben werden - teils sogar, wenn sie ihr ablehnend gegenüberstehen. Ab morgen im Kiosk, jetzt schon online:… 1/ Image
"Der Patient fühlt sich wohl und empathisch mitgenommen": Auch wissenschaftsaffine Ärzte rechtfertigen den Einsatz als #Placebo. Erhalten Menschen ohne aufgeklärte Einwilligung #Homöopathie, widerspreche es den Grundfesten der modernen Medizinethik, sagt eine Medizinethikerin. 2/
Erstmals distanziert sich der Deutsche #Hebammen-Verband klar von der #Homöopathie: "Es gibt keinerlei Evidenz für diese Methode", Mütter müssten hierüber aufgeklärt werden. In der Geburtshilfe sei lange nur mit Erfahrungswissen gearbeitet worden - das solle sich nun ändern. 3/
Read 6 tweets
Mega Thread - The Childhood Vaccine Placebo Myth

Is a true saline placebo used w/ the 💉’s on the childhood schedule?

All evidence I’ve provided is directly from the manufacturers insert or safety reports. This is not my opinion so take it up with FDA & Pharma if you’re mad.
(Diphtheria-Tetanus-Acellular Pertussis-Polio) - In the only trial specifically described in the package insert the control group received the Infanrix and polio vaccines. The package insert doesn’t mention any trial involving a placebo control group.
Read 50 tweets
1/2 "Here, we demonstrate an increased survival of infected #honey #bee #larvae after their #queen was #vaccinated, compared to offspring of #control #queens (#placebo vaccinated)."…
2/2 "These results indicate that #trans-#generational #immune #priming (#TGIP) in insects can be used to majorly enhance #colony #health, protect #commercial #pollinators from #deadly #diseases, and reduce high #financial and #material losses to #beekeepers"
1/2 "The idea came to be known as the “#butterfly #effect” after Lorenz suggested that the flap of a butterfly's wings might ultimately cause a tornado."…
Read 4 tweets
In the @COMPASSPathway trial the 25mg vs 1mg (=placebo) #Psilocybin difference is not only significant statistically, but also clinically. On the MADRS the 'minimal important difference' is ~3-6 points (, the 25mg dose meets this criteria (more context 👇)
The 'minimal important difference' sounds like a low bar to cross, but actually most #antidepressants fail to do so relative to #placebo, - thank you @PloederlM for your work on this, would love to hear your take on this trial!
Lack of blinding remains an issue, but the dose-response relationship should alleviate this concern. As I argued before, #psychedelics macrodose trials most likely will always lack blinding due to obvious drug effects, it is the nature of the intervention.
Read 4 tweets
#OvalMedia (übertragen regelmäßig die Desinformationsveranstaltung #CoronaAusschuss) übertragen aktuell eine "wichtige" Konferenz zum Thema "#5G".

Kurzer Thread. Image
Für 60,75€ (!) bekommt man ein Online-Ticket und kann dem Livestream anschauen.

Wenn man den Bewertungen glauben darf, lässt die Technik von #OvalMedia dann doch zu wünschen übrig.

"nicht erträglich sind die Unterbrechungen. Und ich habe eine Gigabit-Leitung [...]" ImageImage
Und wer kennt sich, wenn es um #5G geht am Besten aus? Richtig. Anthroposophen!

Wie z.B. Michael Glöckler ("Präsidentin der Europäischen Allianz von Initiativen angewandter Anthroposophie"). Image
Read 18 tweets
Zucker her für die Bundeswehr! Der Staat versorgt die Streitkräfte der Bundesrepublik Deutschland mit medizinische Platzpatronen:

Die Verordnung von homöopathischen Globuli und anderen #Placebo-Mitteln (z. B. Meditonsin) durch Truppenärzt_innen ist ausdrücklich vorgesehen. Logo der Bundeswehr, mit PhotoShop satirisch abgewandelt: Ei
Quelle: In der Broschüre "50 (weitere) Tipps für den Truppenarzt" weist OStArzt Dr. Andrea Scheel vom Bundeswehrkrankenhaus Hamburg darauf hin:

"Verordnungsfähig sind: homöopathische Arzneimittel (grundsätzlich zulässig)"…
Wie sehen das @BMVg_Bundeswehr, @bundeswehrInfo,
@SanDstBw? Es besteht seit 225 Jahren kein wissenschaftlich valider Nachweis für eine Wirkung von homöopathischen Mitteln.

Wie ist es mit der Medizinethik? Den unnützen Ausgaben? Der Anerkennung wissenschaftlicher Erkenntnisse?
Read 6 tweets
Despite the importance of #blinding in medical research, most trials don't assess blinding integrity, partially because there is no method to adjust trial results for blinding integrity... until now! New preprint with implications for #microdose and #psychedelic research 🧪🧵👇
First, we define activated expectancy bias (AEB), which is an uneven distribution of expectancy effects between treatment arms due to patients recognizing their treatment allocation. AEB can be viewed as residual expectancy bias not eliminated by the trial’s blinding procedure.
The main idea behind AEB is that if treatment allocation can be deduced by participants, then, treatment expectancy can bias the outcomes in the same manner as it biases non-blinded trials, for example as in open-label trials. Image
Read 11 tweets
A thread on the Films that won the "National Film Award for Best Investigative Film"
(first awarded in 1990)
Documents the violence and terror in Punjab – a land torn apart by religious fundamentalists and a repressive government.

#UnaMitranDiYaadPyaari / #InMemoryOfFriends (1990) by @anandverite.

Exploration of the communal violence that triggered in Ayodhya following the Babri Masjid demolition.

#RamKeNaam / #InTheNameOfGod (1992) by @anandverite.

Read 19 tweets
@Microbioxdame @DanLeHibou @anthony08792 @FiatVoluntasT10 @soyotte39 @Mediavenir 1)
LOL. "Efficacité à 90%" ! 🤣🤣🤣🤡

Vous êtes de nouveau en train de faire de la #FakeMed et de la #FakeScience.

Comme vous prétendez être un très grand Scientifique, vous devriez savoir qu'il y a 2 types d'#Efficacité.
➡️ l'#EfficacitéPotentielle
➡️ l'#EfficacitéRéelle
@Microbioxdame @DanLeHibou @anthony08792 @FiatVoluntasT10 @soyotte39 @Mediavenir 2) Petit rappel de vos cours :
➡️ L’#EfficacitéPotentielle d’un #Vaccin se mesure dans le cadre d’un essai clinique contrôlé et repose sur le nombre de personnes qui, ayant été vaccinées, ont développé "un résultat présentant un intérêt" (en général, la maladie)
@Microbioxdame @DanLeHibou @anthony08792 @FiatVoluntasT10 @soyotte39 @Mediavenir 3)
en le comparant à celles qui ont développé le même résultat après avoir reçu un #Placebo (vaccin factice). Au terme de l’étude, on compare le nombre de personnes malades dans chaque groupe, de manière à calculer le risque relatif de tomber malade
Read 11 tweets
@ASlavitt , can you get some clarity on a group of people that is small in number regarding #BoosterShots . I'm a #Pfizervaccine trial participant who was vaccinated fully by Sept 2020, and now I'm a booster trial participant. I'm pretty sure I'm in placebo group for booster
trial. I have asthma, hashimotos, and am obese, and if @pfizer doesn't make the decision to unblind #placebo group in #boostertrial when the #BoosterShots will be available, I'm probably going to make the decision on my own to leave the trial. Someone needs to clarify the
situation that the vaccine trial participants are in: we were vaccinated a year ago, and some in that group are like me, almost 58, have asthma, hashimotos and am obese. So, we're MORE at risk if we wait for @pfizer Moderna or @HHSGov to clarify this dilemma. There are only a few
Read 4 tweets
📍Solución salina en ECAs de #Epicondilalgias Laterales

💉Usualmente se utiliza este método como #Placebo para comparar los efectos con tratamientos inyectados en patología MSK.

Sin embargo, ¿Es realmente la mejor opción como placebo ante tratamientos inyectados?

⬇️Hilo va!⬇️
📍En los ECAs acerca de Epicondilalgia Lateral, se suele utilizar Soluciones Salinas como tratamiento del grupo control.

De esta forma, buscan comparar esa sustancia inócua Placebo, frente a la Inyección de sustancia activa.

Sin embargo, parece que no es todo tan sencillo...
Como ejemplo, este MA de 2016 evidenció que la inyección de este tipo de sustancias producía efectos positivos en pacientes con OA de rodilla😮!!

En concreto, mejoras significativas y clínicamente relevantes a los 6 meses en EVA dolor o función WOMAC 😱…
Read 19 tweets
1/ Forget COVID for a sec! Come read about 🌟𝘱𝘭𝘢𝘤𝘦𝘣𝘰𝘴🌟 instead.

Is placebo effect as powerful as some suggest?
Not really.
But it's surprisingly consistent, & that has important implications in medicine.

I dug up an old student presentation on them.
Let’s dive in🧵 Quote from Emile Coue "...
2/ The term was 1st used in medicine in the 1800s: Treatment "adapted more to please than to benefit".

Even then, the importance of suggestion/placebos/bedside manner/whatever you call it was known to be tremendously important.
3/ A famous early Placebo-controlled trial (i.e. comparing the "treatment" to an identical sham) used wooden rods in place of Perkins Tractors, which were metal rods made of supposedly "special alloys".
It showed they were no more effective in managing the advertised disorders Front cover of early study ...
Read 16 tweets
"It is now well-established that most pediatric #antidepressant trials were #industry-sponsored & had serious methodological limitations; many trials remained unpublished due to unfavorable results, "

#Children: the sacrificial lambs of capitalism.…
"& those published were mostly ghost-written, selectively reported efficacy outcomes & misrepresented the true rate of treatment-emergent #suicidal events"

Those that claim to care about your health allow #pharmacological & #psychological experimentation on #children & #youth.
"in most countries #antidepressant use has considerably increased in #children & #adolescent over the last 10–15 years (11–13), despite #suicidality warnings, the serious limitations of the evidence-base, & ongoing controversies surrounding risks [] [and] #placebo response."
Read 7 tweets
Harmless #Placebo
64 yr old gentleman. Has mild fatty liver. On meds for high BP. Healthy, farmer. One fine day, he's lethargic. Lost appetite. Feeling under the weather
Gets blood tests done after GP consult. Liver test AST 224 ALT 138. GP says bad fatty liver, starts VitE
Comes back after 14 days. Worsening appetite. Rechecks blood. AST 542 ALT 432. GP refers to me. I ask for alcohol use. Gentleman says never in his life. His family supports him. I ask for #ayurveda #herbals. Says he doesn't believe in that sh*t. I'm impressed. But no diagnosis
3/ Checks for autoimmune liver disease markers, viruses. All negative. Ultimately convinces the elderly man to go for a liver biopsy. He does and the report says. Autoimmune liver disease. Repeat blood markers still negative. Pathologist says ask for drugs. So I do that again.
Read 6 tweets
#Antidepressants seem effective in the clinic but not in controlled studies. Why? Let’s consider all possibilities. @PeterDKramer @AllenFrancesMD @DrHowardLiu @DalackMd @blackdoginst @NAMICommunicate @Got_Anxiety @EikoFried @PsychTimes @matthewckeller @RiadhAbed1 @APAPsychiatric
Most of us who have prescribed antidepressants for thousands of patients have heard hundreds of them report transformed lives. “It is as if I walked out of a dark room into sunlight” “All of a sudden I can experience pleasure again”
But perhaps the effectiveness is an illusion. The improvement of patients taking #placebo is barely better than that for those taking antidepressants.
Here are 10 reasons why antidepressants
->Could seem effective when they are not, or
->Could seem ineffective when they are
Read 18 tweets
Repas dans la belle-famille aujourd’hui, l’occasion de rappeler le métier de feu le grand-père de madame : il était #magnetiseur .

A l’époque , pas de #nofakemed , au contraire.

Comment ça marchait ??? Très simple⬇️
A l’origine le grand-père tenait un magasin de tout et de rien, un « bazar » dans un village au pied des monts du lyonnais à la limite de la Loire et du Rhône
MAIS son gagne-pain, c’était magnétiseur : il soignait tout, ou presque. Sa méthode ?
Read 28 tweets
It took a while to digest the details of over 600 pages, but here is my review and comparative analysis of the #ACTT2 trial that compared #baricitinib vs. #placebo among patients receiving #remdesivir for #COVID19!

Some very interesting insights, I think!

Sit briefly and enjoy!
Will be mainly comparing #ACTT2 to #ACTT1, but also will get some insights and questions that come up when comparing #ACTT2 to the #dexamethasone #RecoveryTrial
The idea of using #baricitinib (aka Bari) for #COVID19 is in this commentary in .@TheLancet from Feb. when Peter Richardson & Co working .@benevolent_ai .@ucl searched drugs and noted that #bari could block inflammation & viral endocytosis.

Read 25 tweets
@myESMO #ESMO20 as a #trainee can be #overwhelming! So many good studies, some more #practicechanging then others, if you missed some and want to understand (albeit at a simplistic #trainee level), sit back, relax and enjoy as we go through some great data #ESMO20 @OncoAlert
1. #NSCLC: 2 major studies #ADAURA #CROWN for adjuvant #EGFRmNSCLC, and advanced #ALK+ experts can provide better perspective @JackWestMD @n8pennell @StephenVLiu @AMansfieldMD @CharuAggarwalMD @NarjustDumaMD @GlopesMd @DevikaDasMD @OncoAlert
1. A) #ADAURA: Stage IB-IIIA #resected #NSCLC with #EGFRm treated with #Osimertinib vs #placebo [SOC prior to this was adjuvant chemotherapy [cisplatin-based doublet based on #LACE metanalysis-] showed improvement in #DFS @NEJM…
Read 19 tweets
🔥Thread hydroxychloroquine #HCQ #COVID19

Pourquoi la très grande majorité des médecins s’accordent aujourd’hui pour dire que l'#HCQ ne marche pas ?

Parce que de très nombreuses études montrent son inefficacité et qu'aucune étude de qualité ne montre son efficacité.
Tout en haut de la pyramide de valeur des études, il y a les essais randomisés de grande ampleur. Il y en a désormais 3 sur l’#HCQ dans #COVID19 dont 1 publié (@NEJM) et 2 partagés via communiqué presse (@MartinLandray @ScienceMagazine). On y ajoute 2 méta-analyses solides.

1er essai : @boulware_dr et collègues

#HCQ en prophylaxie (en prévention de l'infection après exposition à risque) chez 821 patients : autant de patients contaminés par COVID-19 avec #HCQ que #placebo. Effets indésirables plus importants avec #HCQ (40% #HCQ vs 17% #Placebo)

Read 25 tweets
Updated the #RECOVERYtrial topline results summary table of the #dexamethasone arm compared to usual care for treatment of hospitalized patients with #COVID19.

Got additional information colleagues shared in Twitter.

Thread with some comparisons with #ACTT1

#IDtwitter 1/
the #ACTT1 authors have only reported (preliminary) Day 14 mortality, and the #RECOVERYtrial has only posted Day 28 mortality.

But these days the Supplementary Appendices in trial reports have additional relevant information:…

The paper says they were not reporting day 29 mortality, but If you look at Figure S3 in the #NEJM #ACTT1 preliminary report, you have KM estimates out to day 30.

From there you can visualize the probability of death at day

28 (see figure) have left lines and scales
Read 12 tweets
#Placebo ja #nocebo - tapauskertomus:
Joukkue jossa junnuna pelasin lätkää, oli pelimatkallaan yöpynyt hotellissa. Ruokailu tapahtui buffetissa yms. josta oli saanut olutta. Nöösit olivat juoneet sitä antaumuksella. Jokainen oli kännissä kuin käki, siihen saakka kunnes selvisi
että kyseinen olut olikin ollut ykköstä. Tämä johti jokaisen spontaaniin selviämiseen.

Tämä vastaava placebo- ja nocebo -efekti näkyy myöskin ilmiössä nimeltä #koronakriisi. Siksikin #priorisointi ja #testaaminen ovat nyt ne ainoat ratkaisut.
Read 3 tweets
[#Parution] 1999 > Guide pratique de vulgarisation scientifique par #SophieMalavoy via Gallimard Montréal #LaMethSci
[#Parution] 2014 > Quand le paranormal manipule la science - Comment retrouver l’esprit critique par #SergeLarivée via ed. #PUG #LaMethSci
Read 33 tweets
1/ How about NO? RT How About 6 #Vaccines In One? #FDA Approves New #Vaccine #Vaxelis From #Sanofi, #Merck. #bigphrama…
2/ Six #children died in the clinical trails of the new #vaccine from #Sanofi, #Merck. It's on page 8 of the #Vaxelis #vaccines insert on the #FDA website.…
3/ Page 6 of the #Vaxelis #vaccines insert acknowledges it was tested with two other vaccines administered at the same time. There was no saline #placebo trial, and they only looked for serious adverse events for 5 days.…
Read 3 tweets

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