Discover and read the best of Twitter Threads about #coagulation

Most recents (6)

2/5 "#Uncanny #similarities with #amyloid-#disease associated #blood #coagulation and #fibrinolytic #disturbances together with #neurologic and #cardiac problems led us to investigate the #amyloidogenicity of the #SARSCoV2 #spike #protein (#S-protein)."
3/5 "#Amyloid #fibril #assays of peptide library mixtures and theoretical predictions identified seven #amyloidogenic #sequences within the S-protein."
Read 5 tweets

Aquí te compartimos los factores de la #coagulación empecemos:

- I Fibrinógeno, proteína soluble del plasma

- II Protrombina, está pegada a la membrana plaquetaria

- III Factor tisular, se libera del endotelio vascular a causa de una lesión

- IV Calcio
- V Proacelerina (factor lábil) pegada a la membrana plaquetaria

- VII Proconvertina (Factor estable)

- VIII Factor antihemofílico A, está pegado a la membrana plaquetaria

- IX Factor beta adrenérgico (también llamado antihemofílico B)
- X Factor de Stuart-Prower

- XI Factor antihemofílico C

- XII Factor de Hageman

- XIII Factor estabilizante de la fibrina

- XIV Proteína C o antitrombina II-A, dependiente de la vitamina K
Read 4 tweets
🔓 Respuesta al QUIZ !!

💡Hay dos tipos de hemofilia heredada:

Tipo A, es el tipo más común, es causada por una deficiencia del factor VIII, una de las proteínas que ayuda a la sangre a formar los coágulos.
La hemofilia de Tipo B es causada por una deficiencia en el factor IX.
📍 Te explicamos por qué ocurre...

Los genes que regulan la producción de los factores VIII y IX importantes en la coagulación se encuentran solo en el cromosoma X. La hemofilia la causa un gen anormal en el cromosoma X, en 20% por mutaciones espontáneas de gen.
📍Como se hereda...

Si una mujer es portadora del gen anormal en uno de sus cromosomas (las mujeres tienen un par de cromosomas X), ella no tendrá hemofilia, pero será portadora del trastorno. X.
Read 7 tweets

#Pregnancy and #puerperium confer an ⬆️ risk for ischemic as well as hemorrhagic stroke, with incidence rates being 3-fold higher as compared with nonpregnant women


a short 🧵 Image

@DrRickSwartz @patrice_lindsay et al metaanalysis
👉11 studies
👉>85 million #pregnancy and #postpartum admissions in various countries
👉overall incidence of #stroke was 30 per 100,000 hospitalizations👈
@IntJStroke… ImageImage
☑️Age, >40yo OR3.1
☑️Migraine, thrombophilia, SLE, 🫀disease, HTN, thrombocytopenia, diabetes
☑️Pregnancy complications
✅For hemorrhagic stroke: aneurysms, AVM, Hypertensive Disorders of Pregnancy… ImageImage
Read 12 tweets
@MBVanElzakker and I are excited that our new paper on biological factors that may contribute to the development of LongCovid/PASC was published today:…
2/ The paper details mechanisms by which RNA #viruses beyond just #SARS-CoV-2 have be connected to long-term health consequences.
3/ It also reviews literature on acute #COVID-19 and other virus-initiated chronic syndromes such as post-#Ebola syndrome or #ME/CFS to discuss different scenarios for #LongCovid/#PASC symptom development.
Read 10 tweets
Allan Doctor discusses the functional assessment of haemostasis and anticoagulation therapy during critical illness

let’s look at normal #coagulation system #physiology...

New ways of thinking at a cellular level moves from the classic intrinsic and extrinsic a pathway to a cell based process consisting of:
- Initiation
- amplification phase
- propagation phase

And fibrinolysis is an important part of #coagulation #physiology to prevent excess clot growth and clot break down after healing...

It is this process we accelerate with thrombolysis

Read 5 tweets

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