Today's player: #mTORi, mammalian/mechanistic target of rapamcyin inhibitors
Rapamcyin was @US_FDA approved for #kidneytransplant in 2003.
It was isolated from a soil sample from which island in 1975?
It is a key component of the complexes mTORC1 and mTORC 2 - which regulate processes including cell growth, proliferation, and survival.
Take a look at all 3 signals below 👇🏽
nejm.org/doi/full/10.10…
![](https://pbs.twimg.com/media/EEgbezbXYAEMWRG.jpg)
Rapamycin was isolated in 1975 from a soil bacterium, S. hygrocopicus, on Easter Island (Rapa Nui). Anti-fungal properties were described before immunosuppressive activity.
nejm.org/doi/full/10.10…
For 🦕 fans, an important component of the mTORC1 complex is RAPTOR
ncbi.nlm.nih.gov/pubmed/20234352
![](https://pbs.twimg.com/media/EEgeAjoXYAA5S06.png)
cellsignal.jp/contents/scien…
![](https://pbs.twimg.com/media/EEgf0icWwAAdgNZ.png)
journals.plos.org/plosone/articl…
![](https://pbs.twimg.com/media/EEggXtwX4AAF29C.jpg)
#CNI nephrotoxicity may be enhanced mTORi-mediated inhibition of P-glycoprotein efflux of CNI ➡️ increased intracellular CNI concentrations.
mTORi have been also shown to induce or aggravate proteinuria 😭
ncbi.nlm.nih.gov/pubmed/22137729
![](https://pbs.twimg.com/media/EEgi9xuWsAARtro.png)
hindawi.com/journals/jtran…
radiopaedia.org/cases/drug-ind… @Radiopaedia
![](https://pbs.twimg.com/media/EEghXppX4AEp40W.png)
ncbi.nlm.nih.gov/pubmed/30868436
![](https://pbs.twimg.com/media/EEghxEnXsAEEW7K.png)