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Research attempting to use multiple gene therapies to rejuvenate mice from @geochurch lab and published in PNAS after long delay.

tl;dr this thread: Probably not the anti-aging elixir you are looking for.

pnas.org/content/early/…
2/ a year and a half ago we wrote about this project and interest by lab spinout in giving similar "rejuvenation" treatments to dogs (and eventually humans) They have a startup, @rejuvenatebio with a trial open for Cavalier Spaniels. technologyreview.com/s/611018/a-ste…
3/ yesterday, the WSJ used the paper to update the story of the dog gene therapy company, which doesn't seem to have advanced very much. wsj.com/articles/a-new…
4/ Biology reporter at Science with a skeptical note on the venue for publication and the reviewers ... between the lines type stuff that indicate these results in mice were not so compelling /END
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More from @antonioregalado see all

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Antonio Regalado
@antonioregalado
So the first (of many) books about CRISPR babies is out. "The CRISPR Generation" by @kiranmusunuru , a gene editor at Penn Medicine.

First hand account of being let in on He Jiankui's big secret and what he learned.

amazon.com/Crispr-Generat…
Musunuru is first with a CRISPR babies book. He did it by self-publishing with @BookBaby . Interesting model!

There are several other CRISPR books underway, we reported.

technologyreview.com/f/613908/crisp…
You can hear Musunuru talk about his experience on the @laurahercher podcast The Beagle Has Landed (interview from a while back, but covers material also in book. )
beaglelanded.com/podcasts/kiran…
Read 4 tweets
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Antonio Regalado
@antonioregalado
Gattaca embryo test company corrects Nature Scientific Reports paper on predicting traits from DNA which did not disclose financial interests of the founders. (thread)

nature.com/articles/s4159…
2/ May be some other papers without COI (conflict of interest) statements as well. We will see if authors correct
3/While COI discloses the *roles* of the authors in the company, does not disclose any actual financial interest/COI in the specific technology (genetic models) described in the paper.

Like, who owns it -- Michigan State? The company? -- and is it being used commercially.
Read 5 tweets
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Antonio Regalado
@antonioregalado
The dawn of gene-editing to cure inherited disease.

version 1 -- breaking sh*t

ir.crisprtx.com/news-releases/…
The diseases treated, sickle cell, beta-thalassemia, both caused wrongly shaped hemoglobin. that is what carries oxygen in the blood. painful diseases.
but some people with these diseases don't suffer much, because their bodies still produce fetal hemoglobin (whereas, in the rest of us, it's off).

One of many cases in which "strange" cases provide a map to treatment.
Read 8 tweets

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Sapeer Mayron
@sapeermayronnz
It's been a month since @wilson_soli exposed that Samoa had been treating 16 people in an isolation unit with suspected measles in early October. But the @samoa_observer had been following the growing measles crisis long before that, as far back as March. #Thread #MeaslesInSamoa
In March, anti-vaxxer Taylor Winterstein wanted to charge Samoans hundreds of tala to attend a "workshop" on "choice." Dr Helen Petousis-Harris told us her advice is a public health threat. Already, NZ was facing more than 50 cases of the disease. bit.ly/33wGHE6
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Patriot USA 🌪️💊⚖️🍿
@PelicanCarol
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Professor Q
@q_professor
There was traditionalism before Marshall and Gordon. There will be traditionalism, please God, long after they are a footnote in someone's blog post. But there is something intriguing about them which is also unique - and dangerous. #Thread
1. Anyone following the events of the last 40 years is familiar with what the First Things cabal - and notoriously Papal biographer George Weigel achieved, or at least tried to achieve.
2. To cut a long story short, they presided over the unholy chemical wedding of "John Paul II Catholicism" (largely good) and right-liberal fusionism (soft libertarianism and weak social conservatism, exemplified by Reagan or Bush I).
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Moss Robeson
@mossrobeson__
#Thread: Inspired by the CBP Facebook revelations, I decided to take a look at the OUN-B affiliated U.S. Organization for Defense of Four Freedoms of Ukraine (ODFFU) Facebook group, which includes 610 people. In no particular order, here are some profiles that stuck out to me:
Dmytro Zhmailo, spokesman/executive director of Free People, member of Youth Nationalist Congress (MNK), and senior staff for Ukrainian MP Oleh Medunytsia, who himself chaired MNK 2002-2006. Among others, Zhmailo is FB friends with CUN leader S.Bratsiun.
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Dr. Waitman Wade Beorn
@waitmanb
[THREAD] More on the @HolocaustMuseum statement and the letter of concern from the scholarly community.

There are some misunderstandings going on that need to be addressed.

Let's talk about this. Warning: long #thread
Here is the official USHMM statement.

ushmm.org/information/pr…
Here is the Letter of concern by concerned scholars written and coordinated by @DrO_aorzoff and @Anika_Walke. As of now, over 375 have signed.

nybooks.com/daily/2019/07/…
Read 39 tweets
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Dr. Nyri A Bakkalian
@riversidewings
#thread Gather round, my children, harken to my tale. So I'm hanging out at a bar full of furries & nursing a bottle of my favorite drink. It's time to begin the story of Date Masamune: epically flamboyant pansexual badass & 16th century Japanese warlord. It's #drunjhistory time!
Alright, so let's get this thing rollin, shall we?

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