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1/ Excellent update on #COVID19 by @SaraElOualiMD @ibdlive

🔺Despite the rumors-There is NO current treatment for COVID9 - trials on going

🔺#SocialDistancing needed to prevent /delay transmission & #FlattenTheCurve = Not be sick & go to the hospital when it’s beyond capacity
2/ #COVID19 @SaraElOualiMD @ibdlive
Beyond URI #COVID19 can
🔺Cause GI symptoms 50% pts
• ⬆️ w dis severity
•Can preceed fever/URI
🔺Persist in stool up to 47days
•Implications to #GI endoscopy
•?Implication using public BR
🔺Cause Loss of taste/smell
🔺Cause conjunctivitis
3/ #COVID19 @SaraElOualiMD @ibdlive @MRegueiroMD

Older pts are at higher risk of complications & death

BUT young ppl (20-44) are severely affected too:

🔺20% of hospitalized
🔺12% of those in ICU
🔺Up to 20% of death

#SocialDistancing is for everyone! #WereInThisTogether
4/ Update on #COVID19 SECURE-IBD registry by #EricaBrenner @ryanungaro on @ibdlive @MRegueiroMD

🔺🙏🏼Report any COVID19 in #IBD pts covidibd.org

🔺87 reported cases
•1st 15 cases reviewed: Hosp/ICU/death = general population
•Risk factors: age, steroids, IMM, Tofa
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#COVID19 #SocialDistancing #FlattenTheCurve #GI #WereInThisTogether #EricaBrenner #IBD

More from @DCharabaty see all

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Dr Aline Charabaty
@DCharabaty
@stevenbollipo @GutGirlMD @KapuriaMd @renumathyd @BilalMohammadMD @DrDeborahFisher @rodriguezparra_ 1/ Couldn’t agree more with these tips for good colonoscopy ! My top tips: 1- take your time in the sigmoid, put enough air/ water to see where you are going (the more air you put, the further the cecum will be, just like inflating a balloon);
@stevenbollipo @GutGirlMD @KapuriaMd @renumathyd @BilalMohammadMD @DrDeborahFisher @rodriguezparra_ 2/ Reduce Reduce Reduce: Reduce when you reach the splenic flexure, your scope should be at 50; Reduce at turns: hook the tip at the turn and straighten your scope; For a big loop in addition to torquing, flip the scope to make that alpha loop outside the colon on the stretcher
@stevenbollipo @GutGirlMD @KapuriaMd @renumathyd @BilalMohammadMD @DrDeborahFisher @rodriguezparra_ 3/ Ask for the right pressure: at the splenic flexure, get pressure in LLQ (sigmoid); at the mid transverse dip, pressure in LLQ and mid/epigastric to lift that dip. These spots works most of the times, but not all colon are the same, and some needs different pressure points
Read 9 tweets

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Avraham Z. Cooper, MD
@AvrahamCooperMD
1/
 Do you want to learn the mechanisms of the drugs being tested for #COVID-19 (aka SARS-CoV-2)?

The WHO has launched the SOLIDARITY trial, rapidly testing 4 treatment regimens.

This is a quick primer.

sciencemag.org/news/2020/03/w…

#medtwitter #tweetorial
2/
 First, Remdesivir

🔹Adenosine nucleotide analogue that competes w/ ATP incorporation into viral RNA

🔹This inhibits viral RNA-dependent RNA polymerase and blocks replication (in vitro, at least)

See step 4 in the viral life cycle diagram below

ncbi.nlm.nih.gov/pubmed/32020029
3/
 Next, hydroxychloroquine (HCQ)

🔹SARS-CoV-2 infects airway by endocytosis (tweet #2, step 1 in fig.)
🔹HCQ = weak base
🔹It accumulates in and inhibits lysosomes by ⬆️ pH, which blocks endocytosis
🔹HCQ also ⬇️ inflammatory cytokines (? significance)

ncbi.nlm.nih.gov/pubmed/32034323
Read 6 tweets
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Free Fannie
@FreeFannie
Nevada Nonessential businesses and schools are closed til April 14th. On January 1, being HOMELESS is punishable by:
💥up to six months in jail and a $1,000 fine
💥 or POLICE will force you to a crowded shelter. #SocialDistancing not if #homeless
google.com/amp/s/amp.theg…
Catholic Charities of Southern Nevada temporarily closing night shelter after positive ➕ #COVID19
A brief #exposure to staffers and other people that use their services. Right now Catholic Charities of southern Nevada is closing their Emergency nightly services for Men
Read 6 tweets
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COVID-19 Kwara Technical Committee
@KwaraCovid19
Following the outbreak of the deadly #COVIDー19 pandemic across the globe, the Kwara State Government, despite not having any recorded case have swiftly swung into action to prevent the spread of the virus in the state.

Thread...

#Covid19KwaraUpdate
The State Government ably led by His Excellency, Mallam AbdulRahman AbdulRazaq, set-up a Technical Committee on Covid-19.

#Covid19KwaraUpdate
The committee headed by the Deputy Governor of the State, Mr. Kayode Alabi has announced that as part of the already laid down preventive measures against the spread of COVID-19 in the state, there will be a partial lockdown effective from 6am on Friday 27th March 2020.
Read 6 tweets
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Dr. Theresa Tam
@CPHO_Canada
1/7 #COVID19 key concerns in 🇨🇦 right now:
2/7 #COVID19 cases continue to ↑ in 🇨🇦. Of the new cases, those that are linked to community spread now outnumber cases linked to travel or close contact with a traveller.

#SocialDistancing #FlattentheCurve #PlanktheCurve
3/7 Some community cases can be traced back to a known exposure or setting but, for others, the source of exposure is unknown - the latter are the most problematic #COVID19

#FlattentheCurve #PlanktheCurve
Read 7 tweets
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Belgian Smaak
@belgiansmaak
Update on #covid in Belgium after gov press conf tonight (a thread):

All residents to stay at home from 12.00 tom (Wed18 Mar) to limit the spread.

Applies until 5 April, but could be extended. Police granted extra powers for ensuring the confinement is respected.

/1
The move follows the shutdown of bars, cafes & restaurants last weekend.

Essential outings will still be allowed—to buy food & medicine, go to a bank, petrol station or post office, attend a medical app, help an elderly relative or go to work if job cannot be done remotely.

/2
Outdoor exercise—walking, jogging or cycling—will still be "allowed, even recommended" but only with one other person, Sophie Wilmès (Belgian PM) said.

Everyone is advised to keep a distance of 1.5m from each other.

Public transport will continue to run.

/3
Read 10 tweets
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巴丢草 Badiucao
@badiucao
landed in Melbourne
sore throat，sneezing and coughing on place
not sure fever
passengers from Italy sits right beside me…
the whole plan has coughing sound through the flight
I am doing the right thing to report myself to a airport medic now
I will do a test of #COVIDー19
2/ taken to a room for temperature test no fever
went through a question list 4 symptom history，if i met anyone from high risk country China italy
i told them i was in Prague 4 film festival & met many people around world.
but seems they are about letting me go.
3/ airport medicals are calling authority to ask about my measurement，go home or stay for test maybe…
seems phones got difficulty to go through…
personally i wish to stay and have test asap.
but i need to respect their decision.
#COVID2019
Read 33 tweets

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