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Jan 9 • 4 tweets • 8 min read
1/4 "Using #PEPMatch, a newly developed #bioinformatics package which predicts #peptide similarity within specific #amino #acid mismatching parameters consistent with published #MHC binding capacity,..."

nature.com/articles/s4159…
2/4 "... we discovered that #nucleocapsid #protein shares significant overlap with 22 #multiple #sclerosis (#MS)-associated proteins, including #myelin #proteolipid #protein (#PLP). 

#MultipleSclerosis
3/4 "Further computational evaluation demonstrated that this #overlap may have #critical #implications for #Tcell responses in #multiple #sclerosis (#MS) patients and is likely unique to #SARSCoV2 among the major #human #coronaviruses."
4/4 "Our findings substantiate the hypothesis of #viral #molecular #mimicry in the #pathogenesis of multiple sclerosis (#MS) and warrant further experimental exploration."

#SARSCoV2 #COVID19

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More from @TaNaishaJ

TaNaisha NOT MILD Lee Profile picture
Jan 10
1/5 "The analysis revealed that older, #cognitively #healthy #brains showed similar amounts of #dissolvable, #non-#fibrillar #amyloid #protein as #brains of #Alzheimer’s #patients."

#aβ #Aβ #fibrils

gero.usc.edu/2023/01/05/new…
2/5 "But, as the researchers expected, the brains of #Alzheimer’s patients had higher amounts of #insoluble #Aβ #fibrils, the form of #amyloid #protein that aggregates to form the telltale “#plaques” seen in the #disease,..."
3/5 "... higher levels of #fibrillary #amyloid appear to be a better indicator of #poorer #brain #health."
Read 5 tweets
TaNaisha NOT MILD Lee Profile picture
Jan 10
1/5 "#SARSCoV2 #infection is associated with a #surprising number of #morbidities."

#amyloidogenesis #aβ #fibrils #COVID19 #SARSCoV2
#spike
#protein

pubs.acs.org/doi/10.1021/ja…
2/5 "#Uncanny #similarities with #amyloid-#disease associated #blood #coagulation and #fibrinolytic #disturbances together with #neurologic and #cardiac problems led us to investigate the #amyloidogenicity of the #SARSCoV2 #spike #protein (#S-protein)."
3/5 "#Amyloid #fibril #assays of peptide library mixtures and theoretical predictions identified seven #amyloidogenic #sequences within the S-protein."
Read 5 tweets
TaNaisha NOT MILD Lee Profile picture
Jan 10
1/5 As many of you here watch family, friends, associates and colleagues living their best lives out there, as #COVID19 surges, please know that many ARE NOT okay.

"Psychoanalyst Judith Alpert theorizes that our culture is terrified of death, illness, and vulnerability."
2/5 "Thus, “[t]hose who have contact with the #chronically #ill . . . do not want to be #reminded of #vulnerability and #ultimate #demise. In turn, the demand placed on the chronically ill is to #control, #hide, and #overcome the #chronic #illness.” (Alpert, 2012)."
3/5 Many of those who appear to be living their best lives are faking wellness to fit in.
psychologytoday.com/us/blog/chroni…
Read 5 tweets
TaNaisha NOT MILD Lee Profile picture
Jan 10
1/2 "Here, we demonstrate an increased survival of infected #honey #bee #larvae after their #queen was #vaccinated, compared to offspring of #control #queens (#placebo vaccinated)."

frontiersin.org/articles/10.33…
2/2 "These results indicate that #trans-#generational #immune #priming (#TGIP) in insects can be used to majorly enhance #colony #health, protect #commercial #pollinators from #deadly #diseases, and reduce high #financial and #material losses to #beekeepers"
1/2 "The idea came to be known as the “#butterfly #effect” after Lorenz suggested that the flap of a butterfly's wings might ultimately cause a tornado."

technologyreview.com/2011/02/22/196…
Read 4 tweets
TaNaisha NOT MILD Lee Profile picture
Jan 10
1/5 "The 2022 WMO/#UNEP #Ozone Assessment contains the most up-to-date understanding of ozone #depletion, reflecting the thinking of hundreds of international scientific experts who contribute to its preparation and review."

#NOAA

csl.noaa.gov/assessments/oz…
2/5 Does anyone with expertise in this area know why charged particles in plasma from #solar #flares, #coronal #mass ejections (#CMEs) and even #localized #thermonuclear #bursts, i.e. #micronovae, were not considered in this report?
3/5 The recommended terms of reference of the 2022 Assessment for the Scientific Assessment Panel (SAP) was supposed to include assessment of information and research related to
solar radiation management and its potential effect on
the stratospheric ozone layer.
Read 7 tweets
TaNaisha NOT MILD Lee Profile picture
Jan 9
1/4 "Researchers from the University of Colorado Boulder found in a 2019 study that the average house is prone to “#indoor #air quality levels on par with a polluted major city.”"

eurekalert.org/news-releases/…
2/4 "Preliminary results from the study show that #air #quality levels were so poor at the end of the study, the researchers had to recalibrate their #sensitive instruments almost immediately."

#indoor #air #quality
3/4 "So, breathe easy by investing in a high quality #air #purifier. If you’re looking for the best air purifier on the market, we did the research for you by scanning 12 #expert #reviews."
Read 4 tweets

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