Slide as far as you like, but be aware of your changing marketing target.
You generate interest by making your twist fun enough that the new target audience craves the new take.
“Man seeks revenge FOR BURRITO”
That’s my twist and people are eating it up.
“Boy meets girl”
“Boy meets seven girls”
Welcome to harem stories, one of the most popular genres for young men.
You don’t want to go too far because you narrow your audience.
“Boy meets seven girls who are not humanoid and the boy is a robot artist.”