The 1st large study looking at #SARSCoV2 viral loads (VL) in asymptomatic children found that viral loads (VL) were significantly lower compared with symptomatic kids - consistent with the difference in median cycle threshold (Ct) values - 10.3 cycles - between the 2 groups.
Findings published in @JClinMicro were consistent across age (0 - 17 yo), race / ethnicity, sex, institution, although the researchers found that both magnitude of Ct difference & VL lessened with older subgroups. #PCR tests were used for initial #COVID19 detection.
Median adjusted Ct value was 8.6 cycles in asymptomatic children vs. -1.7 cycles in symptomatic kids. Median VL was 2.0 X 103 in asymptomatic children & 1.3 X 107 in symptomatic children. Asymptomatic children with diabetes were most likely to be in the top 25% of asymptomatic VL
Children with asymptomatic #SARSCoV2 #infection had lower levels of #virus in the nasopharynx / oropharynx than symptomatic children but timing of infection relative to diagnosis likely impacted levels in asymptomatic children. jcm.asm.org/content/early/…
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