Discover and read the best of Twitter Threads about #badscience

Most recents (13)

UK ppl should be concerned that head of @RoyalStatSoc #COVID19 diagnostics grp is inaccurately stating facts about testing-Intentionally conflating false positives w positive predictive value (totally different) to make rapid tests look bad #badscience
In the tweet above, to get false positive rate you need to have the number of true negatives in the denominator. If you fail to do that, you aren't measuring the false positive rate. It's a totally different number. Studies show false positive rates for many tests <0.1%.

In the first tweet I said "UK ppl should be concerned"... but c'mon @RoyalStatSoc - why allow this to continue. He's been stating falsehoods and bending stats or performing flagrantly unacceptable/unpublishable analyses for months now. Sowing confusion. How is this helpful?
Read 5 tweets
What’s up with RCTs of #exercise for people w #cancer?

Introducing OREO!

*Outcome Reporting bias in Exercise Oncology trials*

@BenSinghPhD @CiaranFairman @Katebolam @jfc_science @Rosie_Twomey @dnunan79 @IMLahart



There are now hundreds of RCTs in #exerciseoncology & many systematic reviews.

These underpin guidelines & calls for exercise to be part of cancer care.

#exerciseismedicine 2/n
However, in many disciplines including #psychology & #oncology, there is evidence of selective reporting bias:

Reporting the results of some outcomes or analyses & not others, depending on the nature (e.g. significant p-value) or direction (e.g. positive) of the results.

Read 17 tweets
@R_J_Howes @SpringerNature It is a misnomer to assume the appellation of #AcneInversa is peculiar only to Germany.

#HidradenitisSuppurativa and #Dermatology may be associated with a short memory.
@R_J_Howes @SpringerNature Changing a bad disease name to another bad disease name is not good science. But you go right ahead and stand on the calcaneum of dwarves. #Dermatology #HidradenitisSuppurativa
Read 6 tweets
🚨 New Article 🚨 dissects the criminological components of Alberta's Supervised Consumption Site (SCS) Report. I'll summarize and extrapolate below. 🧵 1/15

(Spoiler alert: SCSs don't cause crime)

#abpoli #ableg #scs #CrimTwitter @GoAHealth…
There are countless reasons why the Report isn't worth the paper it's written on. #WastedTaxDollars 2/15
The Report mistreats and misconstrues police service call data, relying on crude measures of "crime". #CrimeFiction 3/15
Read 15 tweets
Where is this nonsense going? Not until the first large Randomised double-blind controlled trial returns a NEGATIVE result - i.e. that the active treatment arm is no better than placebo - will these AYUSH guys have any credibility for their methodology.
The great strength of #ModernMedicine (MM) is not that every new drug with an unpronounceable name coming out of the laboratory works. The great strength of MM is that 99% of these molecules are junked.
The great strength of #MM (Modern Medicine) is not that there are NO charlatans and crooks who do dodgy trials, practice #BadScience, and prescribe inappropriately. The great strength of MM is that these crooks are called out and put right by other, upright, and ethical doctors.
Read 6 tweets
Everyone needs to read this short letter to the Editor, regardless of personal feelings...

“Does ‘dependence’ on opioids constitute a distinct clinical state?”

My thoughts and explanations are in this thread👇, please read & RT to help 🛑 this new HARM!…
Hopefully every1 will put personal opinions aside & recognize this attempt by PROP for what it is, designed to give them tool they need to FORCE each off our effective LTOT & onto Suboxone.

If we can’t work 2gether 4 this & support pros willing to fight w/us, our fight is over.
PROP & their cronies have been quietly pushing for a new diagnostic category.

This would mean if your Dr decides to stop or #ForceTaper your meds and you have fear or even more pain then your ONLY suitable treatment option left is Suboxone.

THEN this actual dX stays with you.
Read 12 tweets
A tweet thread.
Subject: Critical appraisal of Itolizumab in #Coronavirus infection.
Events: 1. @sardesairajdeep ran a programme on 11 July showcasing what was claimed to be a breakthrough in the hunt for a drug that worked against #Covid19. Featured #Biocon's @Kiranshaw
Kiran Mazumdar-Shaw has blocked me so she won't see this thread. You can watch @sardesairajdeep programme here: .
Essentially it explained the #cytokinestorm that happens is some patients with #Covid19 and can be fatal. #Itolizumab counters this.
What is Itolizumab? Here is it's Wikipedia entry: It is a relatively newly developed drug in a class of drugs known as monoclonal antibodies (all of them end in '-mab'). They have been around as a class of pharmacologic agent since 1986.
Read 23 tweets
📌Una revista del grupo Elsevier con IF 3.673 acepta un artículo y posteriormente los autores desautorizan el trabajo porque ellos no lo habían realizado....

Pero hay más... ninguno de los autores sabe quien es uno de los firmantes...

📌Supongo que el hecho de que "neuroprojenitor" aparece mal escrito en el título ya debió hacer sospechar a los editores, pero ni eso...

Este es el paper de marras...
Aparecen diferentes autores pertenecientes a la Universidad de Maryland, a la Jones Hopkins al NIH, la Universidad de Macao y otros... todo muy molón y multicéntrico, mucho USA y mucho China...👇

Ahora es cuando viene la risa....
Read 6 tweets
Lets briefly discuss some of the basic concepts of #epidemiology that may be important in discussing #COVID19

1. Epidemiological triad
2. Evidence based medicine/healthcare
3. Good science vs bad science
The epidemiological triad is a simple model that explains disease causality.

a. agents of disease could be either infectious organisms (bacteria, fungi, virus) or exposures such as chemicals, smoking, foods, toxins

Generally, the agent should be present b4 disease occurs.
b. The host offers an ecosystem for the agent to thrive and cause disease. This usually represents the person.
May factors affect the host's vulnerability to (1) infection and (2) poor outcomes from the disease.

These could be biological or social determinants
Read 13 tweets
This piece on #SARSCoV2 viral load in children and adults has been highly influential.
Can you extrapolate from “Data on viral load” that “we have to caution against an unlimited re-opening of schools and kindergartens in the present situation”
I have serious concerns. 1/7 Response to Christian Drosten group report of viral load by age group
There are two issues: science and politics
On the science
1. There is no methods section about how study population was selected and who they represent
– yes, I know it is a bunch of samples tested in a virology lab - with no denominators about how many samples tested by age 2/7
2. The very low number of samples from children already says a lot about selection into the study. There is no information about their clinical characteristics, stage of infection, etc.
And unequal numbers across the groups makes them very difficult to compare, even visually 3/7
Read 7 tweets
Hey @guardian @guardianscience This would be a really interesting dialogue to continue if you opened it up to the majority of researchers who don’t support the PACE trial and have good relationships with patients, instead of just giving Sharpe a platform.…
There are so many flaws in Sharpe’s argument that I won’t be able to cover them all myself (due to ME), but for one, his attempt to differentiate between ME and CFS to justify their work when he knows full well that in practice it is all considered the same. @guardianscience
This means that if you are anywhere on the spectrum including #SevereME (see #SevereMEday yesterday) with extreme exercise intolerance, then you can be put forward for CBT/GET, and actually many Severe patients were formerly moderate before these “treatments” @guardianscience
Read 10 tweets
THREAD (PART 1 of 4): Why you shouldn’t trust @QuilliamOrg ‘s report on #groominggangs & the claim that 84% of “grooming gang offenders” are Asian. An evidence-based critique. 1/
First, let’s be clear: some Asian men have committed horrific sexual offences against children.The offenders we’ve seen on the news are real & they are certainly not the only ones.I’m not downplaying their vile crimes or the harms caused.I truly mean no disrespect to survivors.2/
I understand the anger, upset & outrage about “grooming gangs”. I don’t have lived experience of child sexual exploitation (CSE). I don’t have all the answers. But what I do know very well is research - & specifically around CSE ( 3/
Read 26 tweets
1. How do we determine the optimal drug policy model given how our policy choices impact on such a wide range of outcomes?

Simple answer: ITS COMPLICATED

So a group of experts including @olerogeberg @ProfDavidNutt & @FMeasham tried & figure out a rational new approach
2. Happy to announce the 1st paper from this long-gestating project has now been published in @ijdrugpolicy
"A new approach to formulating & appraising drug policy: A multi-criterion decision analysis applied to alcohol & cannabis regulation"…
open access
3. before talking about the paper - a bit of background.

Firstly, drug policy evaluations - esp for illegal drugs - has historically been poor; emphasising process measures like arrests/seizures, and in terms of outcomes, being preoccupied with prevalence of use, above all else
Read 28 tweets

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