Discover and read the best of Twitter Threads about #badscience

Most recents (19)

1/n @videnskabdk og @anneringgaard har en artikel, hvor Samir Bhatt fra Imperial College kritiserer vores meta-studie.

Men hvor troværdig er den kritik egentlig? Lad os se på det.
🧵
#dkpol #covid19dk #nedlukninger
2/n Samir Bhatt kritiserer bl.a., at vi bruger ordet "lockdown". "»Hvad betyder lockdowns egentlig? I Danmark og England har der jo været vidt forskellige tiltag, og nedlukningerne har været forskellige på forskellige tidspunkter af pandemien,«
3/n Men Flaxman et al. (2020), hvor Samir Bhatt var medforfatter, bruger selv ordet "lockdown" 👇
Read 8 tweets
Me, checking my mentions, and realising the Guardian have published another Johnan Harri article
NB: I tend to deliberately misspell his name on here, because I hear he's a notorious self-searcher. And I still occasionally get his acolytes sending me threats/wildly untrue accusations. Pretty tragic really, but who has the time to deal with that guff
And if anyone's wondering how/why Harri is still readily published by the Guardian despite, you know, everything he's guilty of, then this old thread of mine may shine some light on that

Read 65 tweets
Trigger warning- Will try keep this short. Uncovering the scale of medical gaslighting and corporate corruption. Who teaches our doctors to dismiss medically unexplained symptoms as hysteria?

Lynn Turner- MUS management PowerPoint, Kings College London ImageImageImage
She also developed the GAS-light model as way of determining which treatments were worth trialling ie cost effectiveness - gauging effectiveness based on patient set goals for graded assessment. If we set the goals, its not on them if the treatments aren't effective, it's on us. ImageImage
Michael Sharpe is a psychiatrist&an author of the fraudulent #PACETrial. He does consulting work for insurance companies & advises them that #ME is a mental health disorder. Here he consulting for Swiss Re, classifying #LC as 'health anxiety'-
Read 11 tweets
Thread
#BadScience: activism masquerading as scholarship

Three scholars started out with a commendable research question: to see whether disinformation was being used in the ‘Tigray’ conflict by both sides! The bad news is they did a very bad job! Exceptionally bad!
For this thread I collaborated with the exceptionally talented @malesadin and here are our findings.

1/ In terms of methodology, the researchers used qualitative methods to contextualize their SM data analysis, but don’t give the details of the qualitative side of the research
This makes it almost impossible for other researchers to replicate their research and confirm or dis-confirm their findings. Why the authors chose to do this is anyone’s guess!
Read 25 tweets
<sarcasm>I'm not normally one to wade into a controversial topic</sarcasm> but having just read the recent #TallElHammam / biblical Sodom paper in Nature: Sci. Rep., I see one serious flaw in how they use their 14C dates. A thread (1/10):
2/10 The authors state "The age of the destruction layer at TeH was modeled using the OxCal radiocarbon calibration program...with the ‘Combine’ computer routine". If you don't understand, cool. Apparently the reviewers didn't either. Let explain it:
3/10 They used an OxCal command to assume from the outset that all the "combined" dates are from the same event. This is NOT a model, rather, it is a specific command to OxCal to take many age estimates of a single event, and calculate a single age of that event.
Read 11 tweets
2/ #GhostManagement #TechnologicalCapture
#ManagedCompetition
"Companies’ connections are like a plate of spaghetti. They have licensing agreements with each other; they even promote each other’s drugs in a number of instances."
3/ #GhostManagement #COI #ProfessionalCapture
"Conversely, doctors who take money from one drug company anticipate getting money from other drug companies—and typically that’s the case. We’ve got doctors who’ve taken money from about 15 different companies in a single year."
Read 9 tweets
‘…ask yourself if the authors are truly trying to inform their readers or if they are instead trying to advance a narrative that would be undermined if they fully enumerated how COVID-19 has harmed children.’
/1
Is UK Paediatrics #SoMe governance dead? When will its leaders act against medics pushing misinformation narratives?

‘Doctors writing about COVID-19 and children have an obligation to inform their readers of essential facts.’ @jeremyphoward 👏👏

You know who, @dgurdasani1 💙
Read 4 tweets
UK ppl should be concerned that head of @RoyalStatSoc #COVID19 diagnostics grp is inaccurately stating facts about testing-Intentionally conflating false positives w positive predictive value (totally different) to make rapid tests look bad #badscience
1/
In the tweet above, to get false positive rate you need to have the number of true negatives in the denominator. If you fail to do that, you aren't measuring the false positive rate. It's a totally different number. Studies show false positive rates for many tests <0.1%.

2/
In the first tweet I said "UK ppl should be concerned"... but c'mon @RoyalStatSoc - why allow this to continue. He's been stating falsehoods and bending stats or performing flagrantly unacceptable/unpublishable analyses for months now. Sowing confusion. How is this helpful?
Read 5 tweets
What’s up with RCTs of #exercise for people w #cancer?

Introducing OREO!

*Outcome Reporting bias in Exercise Oncology trials*

@BenSinghPhD @CiaranFairman @Katebolam @jfc_science @Rosie_Twomey @dnunan79 @IMLahart

Preprint: medrxiv.org/content/10.110…

#openaccess

THREAD🧵1/n
There are now hundreds of RCTs in #exerciseoncology & many systematic reviews.

These underpin guidelines & calls for exercise to be part of cancer care.

#exerciseismedicine 2/n
However, in many disciplines including #psychology & #oncology, there is evidence of selective reporting bias:

Reporting the results of some outcomes or analyses & not others, depending on the nature (e.g. significant p-value) or direction (e.g. positive) of the results.

3/n
Read 17 tweets
@R_J_Howes @SpringerNature It is a misnomer to assume the appellation of #AcneInversa is peculiar only to Germany.

#HidradenitisSuppurativa and #Dermatology may be associated with a short memory.
@R_J_Howes @SpringerNature Changing a bad disease name to another bad disease name is not good science. But you go right ahead and stand on the calcaneum of dwarves. #Dermatology #HidradenitisSuppurativa films.com/id/12305
Read 6 tweets
🚨 New Article 🚨 dissects the criminological components of Alberta's Supervised Consumption Site (SCS) Report. I'll summarize and extrapolate below. 🧵 1/15

(Spoiler alert: SCSs don't cause crime)

#abpoli #ableg #scs #CrimTwitter @GoAHealth

harmreductionjournal.biomedcentral.com/articles/10.11…
There are countless reasons why the Report isn't worth the paper it's written on. #WastedTaxDollars 2/15
The Report mistreats and misconstrues police service call data, relying on crude measures of "crime". #CrimeFiction 3/15
Read 15 tweets
Where is this nonsense going? Not until the first large Randomised double-blind controlled trial returns a NEGATIVE result - i.e. that the active treatment arm is no better than placebo - will these AYUSH guys have any credibility for their methodology.
The great strength of #ModernMedicine (MM) is not that every new drug with an unpronounceable name coming out of the laboratory works. The great strength of MM is that 99% of these molecules are junked.
The great strength of #MM (Modern Medicine) is not that there are NO charlatans and crooks who do dodgy trials, practice #BadScience, and prescribe inappropriately. The great strength of MM is that these crooks are called out and put right by other, upright, and ethical doctors.
Read 6 tweets
Everyone needs to read this short letter to the Editor, regardless of personal feelings...

“Does ‘dependence’ on opioids constitute a distinct clinical state?”

My thoughts and explanations are in this thread👇, please read & RT to help 🛑 this new HARM!

journals.lww.com/pain/Fulltext/…
Hopefully every1 will put personal opinions aside & recognize this attempt by PROP for what it is, designed to give them tool they need to FORCE each off our effective LTOT & onto Suboxone.

If we can’t work 2gether 4 this & support pros willing to fight w/us, our fight is over.
PROP & their cronies have been quietly pushing for a new diagnostic category.

This would mean if your Dr decides to stop or #ForceTaper your meds and you have fear or even more pain then your ONLY suitable treatment option left is Suboxone.

THEN this actual dX stays with you.
Read 12 tweets
A tweet thread.
Subject: Critical appraisal of Itolizumab in #Coronavirus infection.
Events: 1. @sardesairajdeep ran a programme on 11 July showcasing what was claimed to be a breakthrough in the hunt for a drug that worked against #Covid19. Featured #Biocon's @Kiranshaw
Kiran Mazumdar-Shaw has blocked me so she won't see this thread. You can watch @sardesairajdeep programme here: .
Essentially it explained the #cytokinestorm that happens is some patients with #Covid19 and can be fatal. #Itolizumab counters this.
What is Itolizumab? Here is it's Wikipedia entry: It is a relatively newly developed drug in a class of drugs known as monoclonal antibodies (all of them end in '-mab'). They have been around as a class of pharmacologic agent since 1986.
Read 23 tweets
This piece on #SARSCoV2 viral load in children and adults has been highly influential.
Can you extrapolate from “Data on viral load” that “we have to caution against an unlimited re-opening of schools and kindergartens in the present situation”
I have serious concerns. 1/7 Response to Christian Drosten group report of viral load by age group https://twitter.com/c_drosten/status/1255555995671150597?s=20
There are two issues: science and politics
On the science
1. There is no methods section about how study population was selected and who they represent
– yes, I know it is a bunch of samples tested in a virology lab - with no denominators about how many samples tested by age 2/7
2. The very low number of samples from children already says a lot about selection into the study. There is no information about their clinical characteristics, stage of infection, etc.
And unequal numbers across the groups makes them very difficult to compare, even visually 3/7
Read 7 tweets
Hey @guardian @guardianscience This would be a really interesting dialogue to continue if you opened it up to the majority of researchers who don’t support the PACE trial and have good relationships with patients, instead of just giving Sharpe a platform. theguardian.com/science/audio/…
There are so many flaws in Sharpe’s argument that I won’t be able to cover them all myself (due to ME), but for one, his attempt to differentiate between ME and CFS to justify their work when he knows full well that in practice it is all considered the same. @guardianscience
This means that if you are anywhere on the spectrum including #SevereME (see #SevereMEday yesterday) with extreme exercise intolerance, then you can be put forward for CBT/GET, and actually many Severe patients were formerly moderate before these “treatments” @guardianscience
Read 10 tweets
THREAD (PART 1 of 4): Why you shouldn’t trust @QuilliamOrg ‘s report on #groominggangs & the claim that 84% of “grooming gang offenders” are Asian. An evidence-based critique. 1/
First, let’s be clear: some Asian men have committed horrific sexual offences against children.The offenders we’ve seen on the news are real & they are certainly not the only ones.I’m not downplaying their vile crimes or the harms caused.I truly mean no disrespect to survivors.2/
I understand the anger, upset & outrage about “grooming gangs”. I don’t have lived experience of child sexual exploitation (CSE). I don’t have all the answers. But what I do know very well is research - & specifically around CSE (bit.ly/2ER2Uox). 3/
Read 26 tweets
THREAD.
1. How do we determine the optimal drug policy model given how our policy choices impact on such a wide range of outcomes?

Simple answer: ITS COMPLICATED

So a group of experts including @olerogeberg @ProfDavidNutt & @FMeasham tried & figure out a rational new approach
2. Happy to announce the 1st paper from this long-gestating project has now been published in @ijdrugpolicy
"A new approach to formulating & appraising drug policy: A multi-criterion decision analysis applied to alcohol & cannabis regulation"
ijdp.org/article/S0955-…
open access
3. before talking about the paper - a bit of background.

Firstly, drug policy evaluations - esp for illegal drugs - has historically been poor; emphasising process measures like arrests/seizures, and in terms of outcomes, being preoccupied with prevalence of use, above all else
Read 28 tweets

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