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1/ The anniversary of the #LDLBounty will be in a couple weeks. I'm still seeking to gather non-drug/non-gene studies showing a triad of high LDL+high HDL+low triglycerides=high cardiovascular disease. Thus far, I've only seen studies showing the opposite.
2/ This is extremely relevant to #keto/#lchf given this triad of rising LDL, rising HDL, and dropping triglycerides is a very common outcome. Of course, if you follow my work, you know I consider this more likely due to being powered by fat (metabolic) than disease (pathologic)
3/ After six months with no submissions, and on the anniversary of the original #LCCholesterolChallenge, I brought the finder's fee up higher to $1,000 with a $3,000 budget.
4/ We know the reverse form of the triad is associated with disease – particularly low HDL and high triglycerides, which is commonly termed "atherogenic dyslipidemia" in the literature. The association is strong whether LDL is high or low.
5/ Yet where HDL is high and triglycerides are low, *high* LDL is generally *better* than low LDL regarding mortality given my many varied queries with the NHANES data.
6/ I realize it's a very different paradigm to consider LDL could be high for an appropriate reason and that this could actually associate with longevity, but it clearly must be considered if the data is there.
7/ Let's stop looking at LDL in isolation if indeed the context matters with other markers, and I certainly believe it does. If the ⬆️LDL+⬆️HDL+⬇️Triglyceride "Triad" shows likewise results in other major datasets, let's call it what it is – a profile of longevity.
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