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Cecile Janssens
@cecilejanssens
, 3 tweets, 3 min read Read on Twitter
"Between 2006 and 2015, ... colorectal cancer rates increased by 3.47 percent among Canadian men under age 50. And from 2010 to 2015, rates increased by 4.45 percent among women under age 50."

Let's check the data ...
1/2
nyti.ms/2Yyk9zx
Who teaches that fitting a regression line is drawing a straight line and drawing as many other straight lines as needed and wherever needed?
2/2
@f2harrell @statsepi @MaartenvSmeden #epitwitter #statstwitter #peerreviewed @JAMANetworkOpen
jamanetwork.com/journals/jaman…
I am adding a reference to the method here, which I didn't know about (and which I still don't understand why that can be applied to 45 datapoints without over fitting--maybe someone can explain).
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More from @cecilejanssens see all

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Cecile Janssens
@cecilejanssens
Study finds a new test that can check if a breast tumor was effectively removed:

"Its test ... was up to 100 times more sensitive than other similar liquid-biopsy tests in picking up DNA shed by breast cancer cells into the blood."

Wow!
1/3
h/t @pash22
bit.ly/2GUxSe0?utm_so…
"After neoadjuvant therapy, ctDNA concentrations were lower in patients who achieved pathological complete response compared to patients with residual disease (... AUC = 0.83)."
"These results demonstrate high accuracy for assessment of ... residual disease"

Wow!
2/3
Here is the accompanying ROC plot. A reminder that the study was conducted in only 33 patients.

--> waaayyyyyy more research is needed ... in larger sample size too show that this test shows presents a smooty ROC curve with similar AUC. Based on this graph: no guarantee.
3/3
Read 3 tweets
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Cecile Janssens
@cecilejanssens
This commentary shows that highest AUC does not indicate highest utility ... but how realistic is the hypothetical scenario? When does this occur?
(short thread)

jamanetwork.com/journals/jama/…
From the curves, we can see that the ROC 0.74 algorithm includes a risk factor (RF) that is highly sensitive in identifying cases. The RF identifies 30% of the cases and is not found in 'controls'. Why was this RF not considered in the other algorithm?
This is the projected ROC curve when the RF would have been used in the other algorithm. When *nested* algorithms are compared in large enough sample sizes, the extended model generally has the same or larger AUC. I love to see exceptions on this rule of thumb.
Read 3 tweets
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Cecile Janssens
@cecilejanssens
A new Dutch study claims the survival benefits of mastectomy for BRCA carriers are minimal: carriers who had not undergone mastectomy developed breast cancer (BC) more often, but mostly didn’t die from it.
I’m not convinced.
(thread)
link.springer.com/epdf/10.1007/s…
The results follow from a survival analysis, which seem to suggest that a group of young women was followed for 45 years, except that the numbers of women contributing data at each age in each group (under x-axis) were small and went up and down.
This hints that the graphs are a ‘compilation’, which is true: the average age at study entry was approx 40yrs and women were followed for approx 10yrs, not for 45yrs. Hence the small numbers at (lower and) higher ages. This hints to a potential problem: survivor bias.
Read 9 tweets

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Angelux
@Angelux1111
#Women

Trump’s WORLDWIDE Effect on the Global Reproductive Rights of Women

Trump and his conservative Christian-centric administration are using positions of authority to impose religious policies on long-established reproductive rights that put women around the world at risk.
Background

Ronald Reagan signed the Mexico City Policy in 1984. This sweeping mandate against reproductive freedom around the globe denied,

“US federal funds to any organisation involved in providing abortion services overseas or counselling women about them.”
Though revoked by every Democrat and reinstated by every Republican
since, Trump has taken up the cause with renewed vigor.

Every time the global gag has been reimposed by a Republican president, rates of back street and self-administered abortions have increased.
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@Bruno_Brunelli
This Mother's Day, breast health advocates’ daughters share how their moms have inspired them.

#MothersDay #MothersDay2019 #BreastCancerAwareness #breastcancer #HealthCare #GEHealth

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When a mammogram missed Jacquelyn’s breast cancer due to her dense breast tissue, she learned about this technology

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In the mountains of #Peru, a husband and wife run a #Quechuan-speaking center where patients pay what they can and are never turned away due to a lack of resources

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Filomena Rocha
@Filomen03258997
2. The Legacy of US UK France Canada Germany Italy Poland Australia Spain Portugal New Zealand Turkey Romania Denmark Belgium Czech Republic Norway Bulgaria South Korea Azerbaijan Singapore Nato in Afganistan

#Afghanistan #CrimesAgainstHumanity #WarCrime #CrimesAgainstChildren
Invasion of Afghanistan (2001-present) - War crime 🤨👇🏼
1. The Legacy of US UK France Canada Germany Italy Poland Australia Spain Portugal New Zealand Turkey Romania Denmark Belgium Czech Republic Norway Bulgaria South Korea Azerbaijan Singapore Nato in Afganistan🤨👇🏼
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Suzzan Blac
@SuzzanBlac
So the @cpsuk are allowing teen girls & women to be sexually tortured on film. I have evidenced this horror on my blog. Proving much is non-consensual/ DV victims/performers who suffer mental health issues/physical harm to breasts /anus/genitalia etc bbc.co.uk/news/technolog… #VAWG
Also, a significant audience of online violent pornography are children and teenagers. #Pornhub hosts thousands of sexually violent videos that have millions of views. Many of these videos are 'home-made' and single males upload their own sexual offences against girls & women
1) The coercion, exploitation, psychological and sexual abuse of women in pornography (Part one) theviolenceofpornography.blogspot.com/2017/02/the-co…
Read 42 tweets
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Jon Stokes
@jonst0kes
I really don't want to read your rant about US vs. Australian gun laws unless you're willing to show people this chart & talk about it. You can't attribute to the current delta between Australian gun death rates & US ones to the Australian gun ban, b/c that delta was there before
It is always shocking to me how many articles are written in prominent outlets that attribute the difference in gun death rates between the two countries to the Australian gun ban, & how many smart people swallow this & repeat it without question.
If you're going to write an article like this one by @dylanmatt and not talk about the pre-ban delta, then you are actively spreading misinformation and are part of the problem. vox.com/2015/10/5/9454…
Read 8 tweets
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Emad Badi
@emad_badi
THREAD

There is a growing trend to implement development projects oriented towards women economic empowerment (WEE) in #Libya. This is great because it paves the way for changing the cultural paradigm of Libyan society and promotes inclusion of #women in other areas. 1/10
But there are also opportunities/risks that should be observed/mitigated when implementing such projects, given the #Libya-n environment. I’ll try and compile a few here that I hope will be observed by both donors and implementing orgs. 2/10
First, you need to make sure the idea for the project originates from the woman and that she takes full ownership of it. Just suggesting things for her to do is NOT economic empowerment and will have 0 impact, it is advising and will eventually result in failure. 3/10
Read 10 tweets

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