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VIRUS SURVIVAL: NIH has endorsed these new findings: SARS-CoV-2 (virus of #COVID19) was detectable in 📌aerosols for up to 3 hours, 📌up to 4 hours on copper, 📌up to 24 hours on cardboard, 📌up to 2-3 days on plastic & stainless steel. nih.gov/news-events/ne…
2) Key additional observations:
✏️Emerging evidence suggests that people with #COVID19 might be spreading virus w/out recognizing, or prior to recognizing, symptoms. This would make disease control measures that were effective against SARS-1 less effective against #COVID19.
3) Another key finding: 📌In contrast to SARS-CoV-1, most secondary cases of virus transmission of #SARSCoV2 appear to be occurring in community settings not healthcare settings. #COVID19
4) However, 📌healthcare settings are also vulnerable to the introduction and spread of SARS-CoV-2, and the stability of SARS-CoV-2 in aerosols and on surfaces likely contributes to transmission of the virus in healthcare settings. #COVID19 ➡️ We need to urgently protect HCWs!!!
5) One interesting nugget - “On cardboard, no viable SARS-CoV-2 was measured after 24 hours and no viable SARS-CoV-1 was measured after 8 hours” ➡️ it seems the new #SARSCoV2 survives 3x longer on cardboard than the old SARS. #COVID19 nejm.org/doi/full/10.10…
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More from @DrEricDing see all

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Eric Feigl-Ding
@DrEricDing
Not too shabby: “Within a week of receiving a blood sample from a U.S. patient who recovered from #COVID19, a Canadian antibody company identified more than 500 unique fully human antibody sequences, the largest panel of anti-SARS-CoV-2 antibodies to date.
genengnews.com/news/to-develo…
2) They will “assess those antibodies, and find those with the greatest potential against COVID-19 by identifying antibodies that bind the pandemic strain of SARS-CoV-2 the best.” The research platform for discovery was originally funded by @DARPA. #COVID19
3) “We are about to find out very quickly which ones of those 500 will be effective neutralizers. We will have that data very quickly, and that will help us down-select a number to develop for further manufacturing and further testing.” #COVID19
Read 15 tweets
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Eric Feigl-Ding
@DrEricDing
Negative outlook by longtime director of @NIH: “If you look at the rates of new cases that are being diagnosed, we’re on an exponential curve. That curve, some would say, places us only about eight days behind Italy....” #COVID19 theatlantic.com/ideas/archive/…
2) “If true, we have only a very short time before this becomes a national crisis with many people and hospitals quickly becoming very stressed with the ability to handle all of these sick people, especially older people who may need not just bed but even a ventilator.” #COVID19
3) “There are estimates that if nothing goes right and if we fail to flatten the curve and if health systems are overwhelmed, we might see the 📍deaths of as many as a million and a half people📍 in the United States.”😰 #COVID19
Read 10 tweets
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Eric Feigl-Ding
@DrEricDing
Good 💊 news- “favipiravir, developed by a subsidiary of Fujifilm, had produced encouraging outcomes in clinical trials in Wuhan and Shenzhen in 340 patients with “high degree of safety and is clearly effective in treatment”. How well? Thread 🧵 #COVID19
theguardian.com/world/2020/mar…
2) Patients who were given the medicine in Shenzhen turned negative for the virus after a median of four days after becoming positive, compared with a median of 11 days for those who were not treated with the drug. #COVID19
3) In addition, X-rays confirmed improvements in lung condition in about 91% of the patients who were treated with favipiravir, compared to 62% or those without the drug.” #COVID19
Read 7 tweets

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Jonathan Rothberg 🧬🧪
@JMRothberg
Reporting progress on #coronavirus Home Test from our teams internal email: Just wanted to give a brief update from the #molbio team as we build momentum towards delivering an at-home, user-friendly, rapid #COVID19 test...We are actually detecting Covid19 #RNA in solution now! 1/
... we got early proof today that we can do reactions from RNA (the genetics code of #SARSーCoVー2 not DNA so it’s more insidious). Our method (which amplified the RNA without a machine) is very tolerant of #saliva - (we still have to crack open the virus RNA for full proof) 2/
The parenthesis in the above tweets are my commentary and I also edited out jargon. But wanted to share our internal optimism. We now know, except for breaking the #virus open to expose its #RNA we should be able to do a #COVID19 test without a #PCR machine @yale and @Penn 3/
Read 11 tweets
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Dr. Ilin Gilberto dlT
@IlindelatorreMD
#SARS-CoV-2

¿Cuál es el período de incubación?
• 2 a 14 días; mediana 4-5 días.

¿Cómo se transmite COVID-19?
• Gotitas respiratorias (CDC)
• SARS y MERS pueden vivir en la superficie durante días. Es probable que el SARS-CoV-2 se comporte de manera similar.
¿Si estoy infectado, ¿puedo volver a infectarme?
• Aún no se sabe con exactitud, pero parece probable que así sea.

¿Cuál es la tasa de letalidad de COVID-19?
• Depende de la edad del paciente.
Hubo 0% de mortalidad en niños de 0 a 9 años y 14.8% de mortalidad sobre los 80 a.
• Tasa de letalidad aumentó constantemente con la edad mayor de ≥40.
• Tasa de letalidad en proveedores de salud: 0.3 por ciento.
Read 19 tweets
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El internista.
@MediCasos
HILO.

Revisión de artículos e información CIENTIFICA que hay hoy en día sobre el manejo, prevención diagnóstico y tratamiento de #COVIDー19

Atentos.
1. Kings Critical Care.

Fisiopatología:, Xu et al 2/17

SIRA: Caracterizado por daño alveolar difiuso (membranas hialinas).
Se observa daño viral citopatico en los neumocitos, lo que implica daño viral directo, mas que "solo" inflamación.
- Tormenta de citoquinas:
Parecido a sepsis bacteriana o linfohistiocitosis hemofagocitica.

Clínicamente esto se ve con aumento de la PCR y ferritina que aparentemente sirve de seguimiento de severidad y mortyalidad.

Kings Critical Care.
Read 72 tweets
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Jennifer Brea 🦒
@jenbrea
Please stop telling young people they should avoid #COVIDー19 infection to protect the old. Tell them to protect themselves.

Long-term symptoms 6+ mo post-infection:

EBV: 11%
Q fever: 11%
Ross River Virus: 11%
West Nile Virus: 31%
SARS: 87%
Ebola: 90%
COVID-19: We have no idea
In general, the topic of long-term, post-infectious sequelae is not well-studied, probably for the same reasons #MECFS has not been well-studied. But maybe a few hundred million people being infected by a novel, zoonotic virus will (unfortunately) change things.
The quality of data by infectious agent varies––a lot. By the time we start worrying about survivors, the pandemic apparatus has usually long moved on and the money just isn't there to study the people left behind.
Read 16 tweets
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Dr. Angela Rasmussen
@angie_rasmussen
I've had a request from @DocBazac to comment on this @medrxivpreprint by @DrNeeltje, @dylanhmorris, and colleagues, including my terrific collaborators and friends at NIH/NIAID/RML, Drs. Emmie de Wit and Vincent Munster.
medrxiv.org/content/10.110…
This excellent pre-print looked at #SARSCoV2 #HCoV19 #COVID19 #coronavirus viability under different conditions, both as aerosols and on various surface materials including stainless steel, plastic, copper, and cardboard.
The key takeaway is that #SARSCoV2 #HCoV19 is very similar to SARS classic in how long the virus can remain infectious in all these circumstances. Both retain infectivity longest on plastic and stainless steel, although this is reduced substantially after 48-72 hours.
Read 14 tweets
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Angelina Nic
@AngelinaNic6
Concerning the CARONAVIRUS -

Someone got Busy , In The Lab .... If you don t know The virus , How can You Give It A Name , No Cure .... Brilliant timing ! Do you Want The Antidote of This Bug ?

The following information was provided by Timothy Webster
#Coronavirus #US #Patent Number #US7220852B1 Synthesized & Registered/Patented in 2015 [In development since 2003 {This application claims the benefit of U.S. Provisional Patent Application No. 60/465,927 filed Apr. 25, 2003,
which is incorporated herein by reference in its entirety.}]

patents.google.com/patent/US72208…

The US Coronavirus Patent #expired today 01/21/2020, the sameday the first case was announced in the U.S.
Read 19 tweets

Trending hashtags

#covid #helpisbeautiful #Government #COVID19 #ThinkPositive #ไวรัสซารส์ #Ningbo #Florida #CoronaVirusGa #Covid_19 #Ebola #COVIDー19 #FightFlu #Australia #H2020 #MERS #H1N1 #SARS #Coronavid19 #epitwitter #WuhanCoronavirusOutbreak #remdesivir #coronarovirus #Pandemic #Thailand

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