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The @Apple Heart smartwatch atrial fibrillation (AF) prospective trial of ~420,000 people enrolled in 8 months, w/ low #AI notification rate of possible AF (in 0.5%) and validation of signal via skin patch
nejm.org/doi/full/10.10…
@NEJM by @leftbundle @StanfordMed and colleagues
@Apple @NEJM @leftbundle @StanfordMed A previous pragmatic site-less clinical trial to detect atrial fibrillation using demographic data for potential risk instead of an all-comer design
jamanetwork.com/journals/jama/… @JAMA_current by @SteveSteinhubl @ScrippsRTI remotely enrolled participants with average age 74
@Apple @NEJM @leftbundle @StanfordMed @JAMA_current @SteveSteinhubl @ScrippsRTI It's good to get medical research at scale but "all comers" via iOS/iPhone leads to lack of diversity of participants, not representative of Americans nytimes.com/2019/11/14/tec… by @natashanyt w/@HarvardChanDean @HarvardChanSPH @ethanjweiss @UCSF
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Eric Topol
@EricTopol
My interview w/ Manu Prakash @PrakashLab, a hero of mine, who I think is one the great innovators of our era. With global impact for frugal, ingenious inventions as you'll see in this thread medscape.com/viewarticle/92… @Medscape w/ transcript @TeamFoldscope @StanfordEng @Stanford
@PrakashLab @Medscape @TeamFoldscope @StanfordEng @Stanford Last month, over 1 million people around the world, in ~140 countries, have gone Foldscoping with his origami-based microscope invention. First published @PLOSONE in 2014 journals.plos.org/plosone/articl…
@PrakashLab @Medscape @TeamFoldscope @StanfordEng @Stanford @PLOSONE In 2015, Manu was profiled @NewYorker
newyorker.com/magazine/2015/… by @carolynkor Then he had turned into house into a lab; now he's got young kids doing experiments there😉
He's the modern version of Antoine van Leeuwenhoek
Read 8 tweets
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Eric Topol
@EricTopol
As a father and grandfather, a remarkable (scary) report on #climatechange and the perils of health for our offspring thelancet.com/climate-and-he… @LancetCountdown
and how sickening to see the #US as such a negative outlier, emissions worse than any country per capita
@TheLancet
@LancetCountdown @TheLancet "The @guardian newspaper reported last week that two-thirds of people in the #UK now consider the #ClimateEmergency to be the biggest issue facing humankind." thelancet.com/journals/lance… @TheLancet
@LancetCountdown @TheLancet @guardian cover @TheLancet this week
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Eric Topol
@EricTopol
I wonder what Florence Nightingale would have said
wsj.com/articles/behin… by @realrobcopeland
cloud.google.com/blog/topics/in… @Ascensionorg @googlecloud
The balanced, factual @WIRED coverage on this project wired.com/story/google-i… by @GregoryJBarber @MeganMolteni
@WIRED @GregoryJBarber @MeganMolteni There's a lot of 👀@Google. But what about ~50 million patient health system: "It ..hopes to mine data to identify additional tests that could be necessary or other ways in which the system could generate more revenue from patients, documents show" from @WSJ @realrobcopeland
Read 4 tweets

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STPI
@stpiindia
#STPIINDIA has been playing the role catalyst in bolstering the growth of #IT industry by providing state-of-the-art incubation facilities to #startups,#MSMEs & budding entrepreneurs in IT/ITeS sector to nurture tech-fueled entrepreneurship in India.#STPIIncubation #KnowAboutSTPI
In the early 90’s, when development of physical infrastructure needed massive investment, #STPIINDIA pioneered incubation services to nurture budding IT companies & promote them to leverage the enormous opportunities in software exports. #STPIIncubation #KnowAboutSTPI @Omkar_Raii
#STPIINDIA has been providing world-class incubation facilities to #startups, #MSMEs & budding entrepreneurs in #IT industry since 1991 to stimulate the growth of tech entrepreneurship pan-India by enabling hassle-free operations. #STPIIncubation #KnowAboutSTPI @Omkar_Raii
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Jae S Um
@jaesunum
1/ Happy Monday Twitter. ⚠️ #tweetstorm 🌪️ #alert ⚠️

My #LegalGeek #FOMO peaked when I missed @nwaisb talk on #AI #hype which is still ALL OVER MY TWITTER FEED. Plus now I have #ACCAM18 #FOMO so here's a bunch of 🤔re #AI, #MachineLearning, #EmergingTech #hype, and #marketing.
2/ As @ZachAbramowitz thinks there's no fun in agreeing: no, I don't think @nwaisb / @KiraSystems & others have benefited (on net) from the AI hype. I'd say hype hurts us all, bc it trades short term gainz to a few players for long-term pain shared by all.
3/ New entrants can feel the need to build #buzz for brand awareness + brand lift. I wouldn't exactly disagree this may help new offerings generate leads + fill their pipeline. Piggybacking on an existing trend with #hype is a shortcut to buzz, BUT with many pitfalls ⚠️
Read 16 tweets
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Jonathan H Chen
@jonc101x
Closing the loop on #Diagnostics #Tweetorial with example #AppleWatch #AFib #Screening. From a company website: "Atrial fibrillation is a silent killer. The heart arrhythmia causes more life-threatening strokes than any other chronic condition, and will affect 1 in 4 of us."
"But the sad fact is that atrial fibrillation often goes unnoticed: It is estimated that 40% of those who experience the heart condition are completely unaware of it."
Using #AppleWatch technology and #DeepLearning #AI #ML, a device algorithm can reportedly detect atrial fibrillation with high accuracy (c-statistic 93%).
Read 44 tweets
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Jonathan H Chen
@jonc101x
#Tweetorial on #Diagnostics and #Screening interpretation.
An otherwise healthy 40 year old woman comes to you after reading on the internet about a terrible disease that one in a thousand women get, and a highly accurate test that can save her life.
The test is over 99% accurate in people with the disease. For those without disease, the test is only wrong 5% of the time.

You order this test and it comes back positive. The woman anxiously asks you, do I have the disease? What is the chance this woman has the disease?
Assuming they weren't immediately fooled by the "test is only wrong 5 % of the time," most I've asked correctly recognize the stats provided are Sensitivity = 99% and Specificity = 95%, and that the objective is to determine the Positive Predictive Value.
Read 21 tweets
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Tony Breu
@tony_breu
1/
 Should I consider atrial fibrillation a risk factor for pulmonary embolism?

If the right atrium is fibrillating, can’t thrombus form? And if it does, can’t it migrate to the pulmonary vasculature, leading to a pulmonary embolism?

Let's examine these questions...
2/
 We’ll start with a couple questions.

Q1: Do YOU currently consider atrial fibrillation (AF) to be a risk factor for pulmonary embolism (PE)?
3/
 In order to answer my opening question, it will be helpful to understand how thrombus forms in the left atrium (LA).

Q2: Which of the components of Virchow’s triad contribute to LA thrombus formation in AF?
Read 18 tweets

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