Here it is!

#Inktober2020 day 1 in my #PathogenPortraits series. After years of studying this in cow bums, it had to be #EcoliO157

It causes bloody diarrhoea & if that wasn't bad enough, sometimes kidney failure & death. More info @
nhsinform.scot/illnesses-and-…
#sciart #microbiology Inktober2020 E. coli O157 c...
#Inktober2020 day 2 in my #PathogenPortraits series. 'The Clap' (Neisseria gonorrhoeae) b/c who doesn't 💚 green purulent discharge?

It's sexually transmitted but also from mother->newborn during birth to cause blindness.
More info: microbewiki.kenyon.edu/index.php/Neis…

#sciart #microbiology Image
#Inktober2020 day 3 in my #PathogenPortraits series. The very 💛golden💛 #MRSA.

Minds it's own business on your skin, but if it gets inside, methicillin won't do a thing to stop it.

More info at mrsaactionuk.net/MRSA.html #sciart #microbiology Methicillin resistant staph...
#Inktober2020 day 4 in my #PathogenPortraits series - the King O' #cholera!

A waterborne infection
Can cause 'rice water' stools.
Its #Phage-encoded #toxin creates a deadly cesspool!

More info: cdc.gov/cholera/infect…
🚨Suggestions still welcome!🚨
#sciart #microbiology Vibrio cholerae bacteria ca...
#Inktober2020 day 5 in my #PathogenPortraits series - it's super stinky C. diff[icile]!

When your gut flora gets out of whack, C. diff takes advantage & your guts unpack. Then it keeps on coming back!

More info: gov.uk/government/col…
#sciart #microbiology #scicomm #HAIs Clostridioides difficile ba...
#inktober2020 day 6 in my #PathogenPortraits
🟢SNOT ALERT🟢
It's the human rhinoviruses!

Causing >50% of all common colds, these pesky viruses are also responsible for serious respiratory illnesses in the young & elderly.

More info: ncbi.nlm.nih.gov/pmc/articles/P…
#sciart #microbiology Human rhinoviruses cause mo...
#Inktober2020 day 7 in my #PathogenPortraits series - time for slow & steady Mycobacterium tuberculosis (#TB).

Preventable. Curable for now. Yet latent in 1:4 people globally. Active lung TB used to be called consumption.

More info: who.int/news-room/fact…
#sciart #microbiology Mycobacterium tuberculosis ...
#Inktober2020 day 8 in my #PathogenPortraits - as requested, it's Trypanosoma!

These pretty little parasites cause #SleepingSickness. 1st in the blood, then in the head, where they stay until you're dead.

More info: who.int/health-topics/…
#sciart #Microbiology #HAT #tryps #SOS Trypanosoma brucei (rhodesi...
#Inktober2020 day 9 in my #PathogenPortraits series - the natural born killer, #Bdellovibrio!

This #pathogen eats most of the other #bacteria members of this series... 'nuff said?

More info: microbewiki.kenyon.edu/index.php/Bdel…
#sciart #microbiology
(great suggestion @markowenmartin!) Bdellovibrio about to eat a...
@markowenmartin #Inktober2020 day 10 in my #PathogenPortraits. Sth for #PlantSci & #Fungi folks- Hymenoscyphus fraxineus!
🌳
It's causing the #AshDieBack spreading across Europe. 1st leaves blacken & wilt, then cankers starve the #trees
🌳
More info: forestresearch.gov.uk/tools-and-reso…
#Sciart #microbiology The fungus that causes Ash ...
@markowenmartin #Inktober2020 day 11 of my #PathogenPortraits- #microbiology meets #entomology, it's #malaria!
🦟🦟🦟
A Plasmodium sporozoite will morph into many forms, each adapted to the liver, blood, & getting into another female mosquito.
🦟🦟🦟
More info: cdc.gov/malaria/about/…
#SciArt Plasmodium sporozoite - the...
Please wait while we try to reconnect you to a thread of pathogenic doom...
(I had a migraine yesterday and was not good for much, so I guess today I'm playing catch-up!)
#Inktober2020 day 12 of my #PathogenPortraits series - have some #Poliovirus paralysis!

Decades after devastating outbreaks & a desperate race for a #vaccine, #Polio is nearly eradicated. But it's not dead yet...

More info: polioeradication.org/polio-today/po…
#SciArt #Microbiology #Scicomm Poliovirus - not quite dead...
#Inktober2020 day 13 of my #PathogenPortraits series - the infamous #Aspergillus.

If its #spores aren't cleared away from wherever they land inside you, they start growing invasively. Usually in the #lungs. Eeep!

More info: hopkinsguides.com/hopkins/view/J…
#SciArt #microbiology #scicomm Aspergillus - a pathogenic ...
#Inktober day 14 of my #PathogenPortraits series - the 1980s ninja - it's #HIV!
🎗
It hides in #tcells for 10-15 years, like a fine whisky aged, slowly causing its host #AIDS.
🎗
More info: hiv.gov
#SciArt #microbiology Human Immunodeficiency Viru...
#inktober2020 day 15 of my #PathogenPortraits - a plague on all your houses!

Infamous for killing 50M ppl in the 1500s 'black death', #Yersinia is now curable with #antibiotics. Without these, it kills 30-100% of hosts.

More info: who.int/news-room/fact….
#sciart #microbiology Image
#Inktober2020 day 16 of my #PathogenPortraits - flesh eating #bacteria! 😱

But #Strep pyogenes doesn't always want to eat you. It also causes #StrepThroat & #Impetigo. Which is much less scary than necrotising fasciitis.

More info: microbewiki.kenyon.edu/index.php/Stre…

#Sciart #Microbiology Streptococcus pyogenes bact...
#Inktober2020 day 17 of my #PathogenPortraits - [not actually] German [not actually] measles. What?!

#Rubella virus! Causes completely preventable #congenital defects, but 1:5 babies don't have access to the #vaccine

More info: cdc.gov/globalhealth/i…
#sciart #microbiology #CRS Rubella virus can cause ger...
#Inktober2020 day 18 of my #PathogenPortraits - some sticky #Pseudomonas?

P. aeruginosa makes a niche in immunocompromised ppl by forming kickass #biofilms. It does this partly by oozing sticky sugars like alginate.

More info: microbiologyresearch.org/content/journa…
#sciart #microbiology #CF Pseudomonas aeruginosa bact...
#Inktober2020 day 19 of my #PathogenPortraits- give us a twirl, swirly #Borrelia!

B. burgdorferi are spirochaetes (corkscrew shaped #bacteria) that cause #LymeDisease. Spread by ticks & super tricky to diagnose!

More info: lymedisease.org/lyme-basics/ly… @Lymenews
#SciArt #microbiology Borrelia burgdorferi - a sp...
#Inktober2020 day 20 of my #PathogenPortraits- ⏰ to get serious with #Measles

Preventable, but b/c #VaccinesWork, we've forgotten how serious it is. It can cause blindness, pneumonia & death. ➕ it's >6x infectious than #SARSCoV2!

More info: who.int/news-room/fact…
#SciArt Measles morbillivirus cause...
#Inktober2020 day 21 of my #PathogenPortraits - a disease dichotomy w. #Salmonella enterica.

Lots of serovars - can mostly cause gastroenteritis in many hosts. BUT can adapt to cause invasive #typhoid fever.

More info: www1.health.gov.au/internet/main/…
#sciart #microbiology #typhi #iNTS Salmonella enterica bacteri...
#Inktober2020 day 22 of my #PathogenPortraits - I didn't do the horror of #norovirus justice!
🤢
Rapid onset of finding your insides on your outsides, extremely #contagious & most common cause of #gastroenteritis in US.
🤮
More info: nfid.org/infectious-dis…
#SciArt #microbiology Norovirus - a horrible food...
#Inktober2020 of my #PathogenPortraits - the neglected & very tropical #Leishmania!
🌴
There are >20 species that cause cutaneous (skin), visceral (mostly liver & spleen) & mucosal leishmaniasis via sand fly bites.
🌴
More info: cdc.gov/parasites/leis…
#sciart #microbiology #NTDs Leishmania parasites cause ...
#Inktober2020 day 24 of my #PathogenPortraits - some #Listeria hysteria!

A rare cause of food poisoning, but 18x more likely during pregnancy, with a 25% mortality in these newborns.
➕ it grows well in the fridge!
❄😱❄

More info: fda.gov/animal-veterin…
#SciArt #Microbiology Listeria bacteria cause rar...
#Inktober2020 day 25 of my #PathogenPortraits- I'm a sucker for #Giardia's sucker!

A dream team: 1 infectious cyst = 2 trophozoites. These sucker the intestine & then form more cysts that survive for months in cold water.

More info: cdc.gov/parasites/giar…
#SciArt #microbiology Giardia parasites cause dia...
#Inktober2020 day 26 - a #Shigella's sh*t show!

Bristling with ~5 needles to inject & hijack host cells, they also pack a punch with #Shiga #Toxin. The result? Cramps, bloody #diarrhoea & sometimes #KidneyFailure & death.

More info: ecdc.europa.eu/en/shigellosis…
#SciArt #microbiology Shigella bacteria cause bac...
#Inktober2020 day 27 of my #PathogenPortraits - eeek it's #Schistosomes!

They BURROW into your skin from freshwater & lay eggs. That eventually causes lots of problems, depending where in your body they are...

More info: nhs.uk/conditions/sch….
#sciart #microbiology #bilharzia Schistosomes are parasitic ...
#Inktober2020 day 28 of my #PathogenPortraits - chillin' in chilled #poultry, but it's no chicken: it's #Campylobacter!

Kill it with fire. No, seriously, it doesn't tolerate anything over 48 degrees C. Cook it!

More info: who.int/news-room/fact…
#SciArt #Microbiology #diarrhoea Campylobacter bacteria caus...
#Inktober2020 day 29 of my #PathogenPortraits- peckish #Pectobacterium!

Or 'carrot-eater'. It causes soft rot in many veg & slime flux in 🌳. The plant version of flesh-eating, it eats the pectin holding cells together.

More info:
wiki.bugwood.org/Pectobacterium…
#SciArt #PlantPathology Pectobacterium carotovorum ...
#Inktober2020 day 30 of my #PathogenPortraits- how about some #Helminths? It's #Ascaris!

Ingest some eggs & you won't know much about it. If you're a really fab host though, you might end up so full of them you perforate!

More info: cdc.gov/parasites/asca…
#SciArt #Microbiology Ascaris are the most common...
#Inktober2020 day 31 of my #PathogenPortraits - the grand finale, it had to be #Coronavirus, didn't it?

We're all living this one & it sucks balls. #HerdImmunity won't work. Let's hope a #vaccine will.
🤞🤞

More info: who.int/health-topics/…
#SciArt #Microbiology #pandemic Coronavirus - SARS, MERS, S...
#inktober2020 is done... and it really cheered me up during my second bout of #COVID19 and unfun quarantine, so thankee for all your support. Due to popular demand, expect to see these #PathogenPortraits on #redbubble when I get a moment!
#sciart #microbiology #QuarantineLife Inktober 2020 Pathogen Port...
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More from @eliza_coli

7 Sep 20
#Haemolysis data indicates that #disruption of host cell #membranes by rotating #flagella is physically possible, despite what previously published measurements with firing gold nanobeads at tissue cultures tells us.

[Pls read the paper for the more complex story with E.coli]
But what if #flagella did penetrate host cell #membranes? What might that mean?
Well, in vitro at least, #Ecoli and #Salmonella #flagella can enhance #actin #polymerization rates. Interactions with #Cofilin-1 (CFL) had an additive effect... Actin polymerisation rates with flagella from E. coli (H6, H
Read 8 tweets
7 Sep 20
8 years since the first manuscript draft but it's finally here!

The interaction of #Ecoli O157 :H7 and #Salmonella Typhimurium #flagella with host cell #membranes and cytoskeletal components | #Microbiology #Pathogenesis #Thread

microbiologyresearch.org/content/journa…
@strain9000 @ArielBlocker @MicrobioSoc This all started many 🌑🌒🌓🌔🌕🌖🌗🌘🌑 ago...

Jo Elvidge and I were looking at the role of #flagella in early infection of #Salmonella and #Ecoli in relevant animal tissue models (🐖🐄)

We spotted what looked like very intimate adherence... E.coli O157:H7 on Bovine terminal rectal cellsSalmonella Typhimurium on porcine epithelial cells
It was a toughie to quantify back then with the tools we had, but every time we looked, we saw it 🤓
Read 9 tweets

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