Discover and read the best of Twitter Threads about #tcells

Most recents (24)

Excited to share our new paper out at @NatImmunol today! We discovered the limiting factor for #brain #Tregs is #IL2, and developed a new #genetherapy to treat #traumaticbraininjury and other #neuroinflammatory pathologies. 1/12

nature.com/articles/s4159…
The work started more than 10 years ago, after my brother Russell died following a #traumaticbraininjury. The more I read into it, the more treatable #neuroinflammation seems. Obviously there is a #brain delivery problem, but stopping #inflammation is basic #immunology! 2/12 Image
We had a great post-doc, @EmanuelaPasciu1, drive a project showing #Tcells in mouse and human brain, with key functions. Among these T cells were a small population of anti-inflammatory #Tregs, again in mouse and human. 3/12
cell.com/cell/fulltext/…
Read 12 tweets
Announcing TopOMetry, a dimensional reduction (DR) tool to learn #SingleCell data phenotypic topology. Finds >100 CD4 #Tcells in public blood data with very specific marker genes. You can use any method for visualization, such as MDE (@akshaykagrawal):

#bioinformatics

🧵1/16
Pre-print just now on BioRxiv: biorxiv.org/content/10.110…

I'm still learning a lot, as I did this mostly on my own during my clinical rounds in pandemic Brazil. If you spot any mistakes or have comments, please be kind to reach out. I plan on improving.

2/16
In a nutshell: dimensional reduction happens in 'steps' (i.g. kNN, affinity learning, decomposition, optimizing layouts). TopOMetry assumes phenotypic topology (i.e. manifold hypothesis) and approximates the Laplace-Beltrami Operator (LBO) at each of these steps.

3/16
Read 21 tweets
🌲 一棵高大的樹抓住風 🌲

A bi0w3ap0n created by a collaboration of elderly scientists and bureaucrats and spread in a country with an ancient history, accelerates aging in a young, modern population.
Read 4 tweets
⭐T CELLS SUPERSTARS ⭐ Qualche dato davvero interessante e importante da riportare su immunità cellulo mediata contro #Omicron. Vediamoli in questo 3d. Avanti tutta. 1/n
#COVID19 #tcells
Dalle ultime evidenze scientifiche sembrerebbe che la variante di SARS-CoV-2 Omicron (B.1.1.529), fortemente mutata, sarebbe in grado di eludere una frazione sostanziale delle risposte anticorpali neutralizzanti.
2/n
Le quali risposte sono stimolate dagli attuali vaccini con un conseguente aumento delle infezioni ed una riduzione nell'efficacia (non della protezione) del vaccino. 3/n
Read 10 tweets
Did you know that some proteins can increase or *decrease* #CellMigration, depending on the cell type?

Check our review on how ion channels (#Pannexins) & #calciumsignaling regulate immune, non-immune & #cancer migration.

Hot from the press: readcube.com/articles/10.33… #SciComm
/1
It all started when we wrote something with @palomi_rock
The intro was so good & had so much new data that we decided to make a 'short' review/update of pannexins in #immunecells, focus on cell migration.
But things got out of hand & we started to include more cell types 😅🤷🏽‍♂️
/2
Then, @LpzLpz_Tami joined to help with migration of immune cells, such as #DendriticCells, #Tcells, #Neutrophils, and to do the beautiful figures @BioRender 😍
Next, @APalacio_s joined to bring a broader vision of migration's impact during neuroinflammation, senescence, etc
/3
Read 6 tweets
🚨Advance publication out today in @Nature🚨
Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2
nature.com/articles/s4158…

Our latest work as part of covid-consortium.com
@UKCICstudy
Huge thanks go to all participants (HCW and medical students are the best), funders ...

@UKCICstudy
@UKRI_News
@NHSBartsHealth
@NIHRresearch
Read 10 tweets
Do children produce different types of #antibodies(Abs) against #SARSCoV2 than adults? 1/ Image
Yes, children mostly produced Abs aimed at #Spike protein, which the virus uses to enter cells. Adults generate similar Abs, but also develop Abs against the #Nucleocapsid protein, which is essential for viral replication 2/

pubmed.ncbi.nlm.nih.gov/33154590/
#Nucleocapsid protein is typically released in significant quantities only when a virus is widespread in the body.
What does it mean? The kids lacked nucleocapsid-specific Abs, which suggests that they aren’t experiencing widespread infection. 3/
Read 8 tweets
❗non-peer reviewed pre-print❗

Our latest work as part of covid-consortium.com @UKCICstudy

👩‍🔬Pre-existing polymerase-specific T cells expand in abortive seronegative #SARSCoV2 infection👨🏻‍🔬

medrxiv.org/content/10.110…
This has been an incredibly enjoyable and interesting project to work on - and huge thanks go to all participants (HCW and medical students are the best❗️), funders ...

@UKCICstudy @UKRI_News @NHSBartsHealth @NIHRresearch
Read 9 tweets
A metal ion orients SARS-CoV-2 mRNA to ensure accurate 2′-O methylation of its first nucleotide
» doi.org/10.1038/s41467…
The #SARSCoV2 #coronavirus is able to utilize the changes in metal ion concentrations to disguise itself in the human host body thus evading immune responses. Image
Efficacy of #clarithromycin on #COVID19 pneumonia without oxygen administration; protocol for multicenter, open-label, randomized-controlled, 3-armed parallel group comparison, exploratory trial #CAMECOVID
» doi.org/10.1101/2021.0…
Japan Registry of Clinical Trials jRCTs071210011 Image
The influence of #HLA genotype on the severity of #COVID19 infection
» doi.org/10.1111/tan.14…
A genetic link has been discovered explaining why some people catch #Covid but don't get sick. The gene is found three times as often in people who are #asymptomatic. Image
Read 199 tweets
Ultimate victims of media induced fear & politically correct #posturing will be our #children. "hygiene hypothesis: "when exposure to parasites, bacteria, & #viruses is limited early in life, children face a greater chance of [] allergies, asthma, & other #autoimmune diseases..." Image
Dec 10, 2020, Nature: "'#Children are very much adapted to respond — & very well equipped to respond — to new #viruses,' [] even when they are infected w/ #SARSCoV2, children are most likely to experience #mild or #asymptomatic illness." Image
"These children’s #immune systems see the #virus & mounts this really quick & effective immune response that shuts it down, before it has a chance to replicate to the point that it comes up positive on the swab diagnostic test",

Natural #Immunity is not a conspiracy theory.
Read 12 tweets
🔝5 Concerns about #SARSCoV2 #Biology: A Call to Pause, Deliberate, and Revise Policy─This review is intended both as a basic resource and to initiate an open and critical dialog about SARS-CoV-2 biology for an independent and public call to action. jjcouey.medium.com/5-concerns-abo…
Structural basis of ribosomal #frameshifting during translation of the #SARSCoV2 #RNA #genome
» doi.org/10.1126/scienc…
A unique feature of the SARS-CoV-2 genome controls protein synthesis and presents an "Achilles heel" of the virus. Image
Brainstem neuropathology in two cases of #COVID19: #SARSCoV2 trafficking between #brain and #lung
» doi.org/10.1007/s00415…
Neuropathologic evidence strongly suggests that the pathophysiology of COVID-19 related respiratory failure includes a neurogenic component. Image
Read 213 tweets
Reducing #COVID19 #Airborne #Transmission Risks on #PublicTransportation Buses
» doi.org/10.1101/2021.0…
Wearing of #facemasks reduced the overall particle count released into the bus by an average of 50%, the dispersion distance by several feet and #aerosol particles by 84.36%. Image
🔝#SARSCoV2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis
» doi.org/10.1016/j.jacb…
#COVID19 can kill heart muscle cells, interfere with contraction. Details of how #coronavirus infects #heart: models of tissue damage may help develop potential therapies. Image
High-content screening of coronavirus genes for innate immune suppression reveals enhanced potency of SARS-CoV-2 proteins
» doi.org/10.1101/2021.0…
196 protein products of seven coronaviruses: the genes encoded by #SARSCoV2 are generally more potent immune suppressors than others Image
Read 236 tweets
⚠️#Ocular #MRI Findings in Patients with Severe #COVID19: A Retrospective Multicenter Observational Study
» doi.org/10.1148/radiol…
All patients had nodules in the macular region, 8/9 (89%) had bilateral nodules, 2/9 (22%) had nodules outside the macular region. Screening needed. Image
⚠️🔝New-Onset #IgG #Autoantibodies in Hospitalized Patients with #COVID19
» doi.org/10.1101/2021.0…
An international team of researchers studying COVID-19 has made a startling and pivotal discovery: The virus appears to cause the body to make weapons to attack its own tissues. Image
⚠️🔝Patterns of myocardial injury in recovered troponin-positive COVID-19 patients assessed by cardiovascular magnetic resonance
» academic.oup.com/eurheartj/adva…
Damage to the heart found in more than half of #COVID19 patients discharged from hospital who show raised levels of troponin. Image
Read 235 tweets
How a #vaccine works: when we get #covid19 we make #antibodies and #Tcells. A #vaccine introduces #antigens: heat-killed, parts of #virus, #mrna that makes virus #spike into our bodies to produce the antibody and Tcells WITHOUT infecting us with #coronavirus & making us sick. 1/ ImageImageImageImage
When a new disease comes along like #COVID19 #coronavirus our body does not have #antibodies or #Tcells to fight it off. First we recognize it (the #antigen) and START to BUILD our defense or army to fight it back. #vaccines #vaccine (from who.int) 2/ Image
The #vaccine helps us to build an army that is ready to fight the #coronavirus before it tries to infect us. The #vaccines are parts of the virus or #antigens that our body knows are foreign invaders (BUT can’t attack or make us sick). #mrna vaccines are different 3/ Image
Read 8 tweets
Our new pre-print is out @biorxiv_immuno! We studied #SARSCoV2 specific #Tcells in asymptomatic infection. Two important messages:
Within the first month after infection, the magnitude and pattern of the SARS-CoV-2 specific T cell response was similar to COVID-19 patients; however, their frequency seems to decrease slightly faster. Image
We studied the functionality of SARS-CoV-2 specific T cells in a slightly unconventional, but maybe more meaningful way, by stimulating them with SARS-CoV-2 peptides directly in whole blood. Image
Read 5 tweets
A compilation on current data on seasonality of SARS-CoV-2 as well as historic data on other virus, such as common cold HCoV's and influenza

➡️ Temperature
➡️ Humidity
➡️ UVB
➡️ Vitamin D
➡️ Indoor vs outdoor
➡️ Dose exposure
➡️ Ventilation

1/x
Leading virus immunity expert Iwasaki on seasonality of virus: highlights the importance of the environmental factors: temperature, humidity as well as vitamin D status, in modulating immune responses to viral infections in the respiratory tract annualreviews.org/doi/10.1146/an…
2/x
Temperature, Humidity, and Latitude Analysis to Estimate Potential Spread and Seasonality of Coronavirus Disease 2019 (COVID-19).
3/x
jamanetwork.com/journals/jaman…
Read 40 tweets
Here it is!

#Inktober2020 day 1 in my #PathogenPortraits series. After years of studying this in cow bums, it had to be #EcoliO157

It causes bloody diarrhoea & if that wasn't bad enough, sometimes kidney failure & death. More info @
nhsinform.scot/illnesses-and-…
#sciart #microbiology Inktober2020 E. coli O157 c...
#Inktober2020 day 2 in my #PathogenPortraits series. 'The Clap' (Neisseria gonorrhoeae) b/c who doesn't 💚 green purulent discharge?

It's sexually transmitted but also from mother->newborn during birth to cause blindness.
More info: microbewiki.kenyon.edu/index.php/Neis…

#sciart #microbiology Image
#Inktober2020 day 3 in my #PathogenPortraits series. The very 💛golden💛 #MRSA.

Minds it's own business on your skin, but if it gets inside, methicillin won't do a thing to stop it.

More info at mrsaactionuk.net/MRSA.html #sciart #microbiology Methicillin resistant staph...
Read 34 tweets
I recommend reading about immunological synapses to better understand how various immune cells (particularly T cells and NK cells) can grab onto antigens and aid B cells in maturing higher affinity BCRs and antibodies, as well as encourage division

en.m.wikipedia.org/wiki/Immunolog…
CD8+ “Killer” T cells: jcs.biologists.org/content/129/15…
B cells and CD4+ Th cell mediated antibody formation and B cell activation:

step1.medbullets.com/immunology/105…
Read 17 tweets
#Antibody response usually protects against infection/re-infection but #Tcells could protect against clinical signs of disease. #COVID19
The paper from #1990 analyzed the antibody response and clinical symptoms of the common cold #coronavirus #229E. Neutralizing antibody titers declined within 1 year after 1st challenge, and 70% from the "immunized" cohort got re-infected but none showed clinical symptoms.
This most likely explanation is that clinical symptoms were controlled by virus-specific T cells. There is an assumption here that a protective level of antibody would have prevented re-infection in the first plays
Read 11 tweets
"The Lancet‘s fraudulent concealment of genetics, and its own conflicting interests, while condemning #coronavirus conspiracy theorists, gives the appearance of “crisis capitalism,” and complicity in the COVID-19-SARS/HIV-1 #Wuhan ‘Event 201‘ biocrime." Image
The 'Scientific' arguments going on behind the scenes on #Covid_19 should be a wake-up call to the 'TRUE' dangers the world is being exposed to! 'BOTH' sides of the argument are labelling the other 'Conspiracy Theorists'. Only one of them can be! Image
The Lancet writes that "Conspiracy theories do nothing but create fear, rumours, and prejudice...." #Covid_19 Image
Read 52 tweets
1/ A short #tweetorial introducing human leukocyte antigen (HLA) and typing...an important and often confusing topic in #transplantation #kidneytransplant

#FOAMed @MedTweetorials

What is an "HLA"?
2/

HLAs = cell surface proteins encoded by highly polymorphic major histocompatibility complex (MHC) genes on Ch 6 🧬

In #transplantation, HLA proteins are #polymorphic antigens ➡️ alloreactive trigger for the immune response ➡️ can ultimately lead to organ #rejection ☠️
3/ The 2 primary classes of MHC molecules are 1⃣ and 2⃣.

Class 1⃣ MHC are found on the cell surface of ALL nucleated cells + platelets. Their role is to present intracelleular peptide fragments to CD8 #Tcells
Read 8 tweets

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