Discover and read the best of Twitter Threads about #tcells

Most recents (2)

1/ A short #tweetorial introducing human leukocyte antigen (HLA) and important and often confusing topic in #transplantation #kidneytransplant

#FOAMed @MedTweetorials

What is an "HLA"?

HLAs = cell surface proteins encoded by highly polymorphic major histocompatibility complex (MHC) genes on Ch 6 🧬

In #transplantation, HLA proteins are #polymorphic antigens ➡️ alloreactive trigger for the immune response ➡️ can ultimately lead to organ #rejection ☠️
3/ The 2 primary classes of MHC molecules are 1⃣ and 2⃣.

Class 1⃣ MHC are found on the cell surface of ALL nucleated cells + platelets. Their role is to present intracelleular peptide fragments to CD8 #Tcells
Read 8 tweets
(1/5) Our #neoantigen platform harnesses bioinformatics (RECON®), peptide design, and immune responses (NEO-STIM™) to generate #neoantigen vaccines and T cell therapies. Our platform continuously improves with data from our ongoing clinical trials.
(2/5) Our RECON® bioinformatics engine is at the core of our #neoantigen platform. RECON identifies, predicts and selects the most therapeutically relevant #neoantigen targets associated with each patient’s tumor.
(3/5) NEO-STIM™, our proprietary method to stimulate #Tcells in the laboratory environment, replicates nature’s process to elicit immune responses. NEO-STIM allows us to generate neoantigen-specific #Tcells and TCRs for use in our therapies.
Read 5 tweets

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