#Plasma from recovered #COVID19 patients with high levels of #antibodies appeared to delay / stop progression of illness in mildly ill older adults infected with #SARSCoV2, a study published in @NEJM concluded. 🧵nejm.org/doi/full/10.10…
Researchers at Fundacion INFANT in Buenos Aires, #Argentina, led the small randomized, controlled, double-blind #clinicaltrial of the effects of infusing #convalescent #plasma in 160 older adults within 72 hours of symptom onset, half of whom received the treatment.
The patients were either 75 years and older with or without underlying illnesses, or 65 to 74 years with at least one underlying condition. The trial was stopped early because #COVID19 cases substantially declined in #BuenosAires, precluding continued recruitment.
Of the 80 patients in the intention-to-treat population given #convalescent #plasma, 13 (16%) developed severe #COVID19, 25 of 80 (31%) given a placebo (relative risk [RR], 0.52; RR reduction, 48%). 2 in the convalescent plasma group (2.5%), 4 in the placebo group (5%) died.
Modified intention-to-treat analysis (excluding 6 who developed severe illness before #plasma / placebo infusion) showed a larger intervention effect (RR, 0.40), efficacy of 60%. 9 of 76 patients (12%) in the plasma group; 23 of 78 (29%) in the placebo group became severely ill.
No #immunoglobulin G (IgG) correlate of protection was found between mild & severe #COVID19 cases but researchers saw a dose-dependent effect for IgG concentrations in plasma bags. Donors with higher-than-the-median #antibody levels demonstrated a relative risk reduction of 73.3%

• • •

Missing some Tweet in this thread? You can try to force a refresh

Keep Current with Dr. Melvin Sanicas 🩺🔬

Dr. Melvin Sanicas 🩺🔬 Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!


Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @Vaccinologist

26 Oct 20
Curious to know the top #ConspiracyTheory themes or #misinformation sub-topics in the #COVID19 #infodemic? Check this out & vaccinate yourself against false information. Excellent study by @Sarah_Evanega @mark_lynas Jordan Adams & Karinne Smolenyak @ScienceAlly #thread 🧵
The “miracle cures” sub-topic accounts for more #misinformation coverage than the other ten sub-topics combined. It is dominated by a peak on April 24 corresponding with President Trump’s press conference statements about the potential of using #bleach or other #disinfectants.
Mentions of #conspiracytheories linked to alleged "secret new world orders” or “deep state” government bodies existed throughout the time period and were referenced in passing in conversations that mentioned or listed widespread conspiracies.
Read 7 tweets
25 Oct 20
The 1st large study looking at #SARSCoV2 viral loads (VL) in asymptomatic children found that viral loads (VL) were significantly lower compared with symptomatic kids - consistent with the difference in median cycle threshold (Ct) values - 10.3 cycles - between the 2 groups.
Findings published in @JClinMicro were consistent across age (0 - 17 yo), race / ethnicity, sex, institution, although the researchers found that both magnitude of Ct difference & VL lessened with older subgroups. #PCR tests were used for initial #COVID19 detection.
Median adjusted Ct value was 8.6 cycles in asymptomatic children vs. -1.7 cycles in symptomatic kids. Median VL was 2.0 X 103 in asymptomatic children & 1.3 X 107 in symptomatic children. Asymptomatic children with diabetes were most likely to be in the top 25% of asymptomatic VL
Read 4 tweets
9 Jul 20
#Airborne transmission: defined as the spread of an infectious agent caused by the dissemination of droplet nuclei (#aerosols) that remain infectious when suspended in air over long distances & time. What do we know about this route for #COVID19 #SARSCoV2? A #thread 🧵
Experimental studies have generated #aerosols of infectious samples using high-powered jet nebulizers under controlled laboratory conditions. #SARSCoV2 #Covid_19 #IDtwitter
Some studies in #healthcare settings where symptomatic #COVID19 patients were cared for but where #aerosol generating procedures were not performed found #SARSCoV2 #RNA but the quantity of RNA detected was in extremely low numbers. #airborne #transmission
Read 4 tweets
29 Apr 20
At least 7 teams are developing #SARSCoV2 #vaccines using a weakened / inactivated virus. Several existing vaccines are made this way, i.e. #measles & #polio #vaccine. Sinovac Biotech started to test an inactivated SARS-CoV-2 #COVID19 vaccine. #scicomm
At least 25 groups are working on viral-vector #SARSCoV2 #COVID19 #vaccines. A #virus such as #measles or #adenovirus is genetically engineered so it can produce #coronavirus #proteins in the body. These #viruses are weakened so they CANNOT cause disease.
At least 20 teams are using genetic instructions (#DNA or #RNA) for a #SARSCoV2 #coronavirus #protein that prompts an immune response. The nucleic acid is inserted into human cells, which churn out copies of the #virus protein; most encode the virus’s spike protein. #COVID19
Read 5 tweets
25 Apr 20
Some have suggested that detection of #SARSCoV2 antibodies could be a basis for an “immunity passport” / “risk-free certificate” that will enable individuals to return to work. Currently, there is no evidence those who have recovered from #COVID19 are protected from re-infection.
Immunity to a pathogen through natural infection is a multi-step process that usually takes place over 1-2 weeks. The body responds to a viral infection immediately with a non-specific innate response: macrophages, neutrophils, dendritic cells slow the progress of the virus.
This non-specific response is followed by an adaptive response i.e. body makes #antibodies that specifically bind to the #virus. These #antibodies are proteins called #immunoglobulins. The body also makes T-cells that recognize & eliminate other cells infected with the virus.
Read 8 tweets
23 Apr 20
A #thread on the origin of the Severe Acute Respiratory Syndrome #coronavirus-2 #SARSCoV2, the #virus causing #COVID19. SARS-CoV-2 was identified early January 2020; genetic sequence shared publicly on 11 January. #scicomm [image 감사합니다 @IBS_media] @Virologist_11 @dirgarambe
Full genetic sequence of #SARSCoV2 from early human cases & sequences of other virus isolated from human cases from China & all over the world since then show that SARS-CoV-2 has an ecological origin in #bats.
All available evidence to date suggests that #SARSCoV2 #coronavirus has a natural animal origin and is not a manipulated or constructed virus. nature.com/articles/s4159…
Read 8 tweets

Did Thread Reader help you today?

Support us! We are indie developers!

This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal Become our Patreon

Thank you for your support!

Follow Us on Twitter!