Discover and read the best of Twitter Threads about #E484K
Most recents (10)
1/You have no doubt heard much lately about the recently designated #COVID19 #variant, #omicron.
I would like to distill what we know, what we do not know, and what this all means for you right now.
I would like to distill what we know, what we do not know, and what this all means for you right now.
2/On 11/26/21, the @WHO officially designated B.1.1.529 (#omicron) a "variant of concern."
It cited a "large number of mutations, some of which are concerning" and "preliminary evidence" of "an increased risk of reinfection with this variant.."
who.int/news/item/26-1…
It cited a "large number of mutations, some of which are concerning" and "preliminary evidence" of "an increased risk of reinfection with this variant.."
who.int/news/item/26-1…
3/In short, scientists are concerned because #omicron exhibits an unusual number of mutations across the #SARSCoV2 genome, with >30 on the spike protein.
The spike is the part of the virus that allows it to gain access to human cells and reproduce. (h/t @_nference)
The spike is the part of the virus that allows it to gain access to human cells and reproduce. (h/t @_nference)
Is it okay to label #delta variant as #Covid21?
I think it is too premature to even think so. AFAIK, there is still only one ST of #SARSCoV2. It is nothing but a SCAREMONGERING news! 1/
I think it is too premature to even think so. AFAIK, there is still only one ST of #SARSCoV2. It is nothing but a SCAREMONGERING news! 1/
Like all viruses, #SARSCoV2 will continue to evolve. But it has limited number of moves available. It seems it is near to its ‘end game’. There is just not a lot of space for the spike to continue to change in ways that allow it to evade Abs but still bind to its receptors 2/
#Substitutions that allow the virus to resist antibodies will probably also decrease its affinity for #hACE2. This is exactly what we have seen with #DeltaPlus 3/
#DELTA DIARY: It is clear we are now dealing with a virus that spreads far more easily - probably more than twice as easily - as the version that emerged in #Wuhan at the end of 2019 1/
science.thewire.in/health/face-wi…
science.thewire.in/health/face-wi…
The #Ro was around 2.5 when the pandemic started in Wuhan and could be as high as 8.0 for the Delta variant 2/
DELTA is evolving: A new, more genetically diverse cluster, lineage AY.1 (which is termed as #Delta+) with a new spike substitution #N417K having immune escape property, has emerged independently in some countries @vinodscaria 3/
#CoronavirusUpdate 2021/6/1🇫🇷仏AFPが新型コロナ変異株のファクトファイルを公開。これまでの変異株をWHO指定の呼称「アルファ」「ベータ」「ガンマ」…で表記。興味深いことに #B16171 「カパ」についてはそこから派生した #B16172 を「デルタ」と表記。これではすぐに24字を使い果たしそうだ。
Tra le #mutazioni del virus che preoccupano di più ci sono la #N501Y e la #E484K.
La prima permette a SARS-COV-2 di legarsi meglio al recettore ACE2, in altre parole i virus con questa mutazione riescono a entrare più facilmente nelle nostre cellule. 1/
La prima permette a SARS-COV-2 di legarsi meglio al recettore ACE2, in altre parole i virus con questa mutazione riescono a entrare più facilmente nelle nostre cellule. 1/
Variante inglese 🇬🇧 (B.1.1.7), sudafricana 🇿🇦 (B.1.351) e brasiliana 🇧🇷 (P.1) hanno tutte quante la mutazione N501Y.
Probabilmente, è proprio per questo motivo che queste varianti tendono a essere più contagiose. 2/
Probabilmente, è proprio per questo motivo che queste varianti tendono a essere più contagiose. 2/
La E484K, invece, aiuta il virus a sfuggire agli #anticorpi, pertanto potrebbe ridurre in parte l'efficacia dei #vaccini.
La #varianteinglese non ha questa mutazione (per ora), ma brasiliana e sudafricana sì. Per questo sono così temute! 3/
La #varianteinglese non ha questa mutazione (per ora), ma brasiliana e sudafricana sì. Per questo sono così temute! 3/
Si je devais parier sur les annonces de O. #Veran ce soir je dirais:
- on devrait arriver au million de vaccins fin janvier
- il n'est pas sûr qu'on vaccine tous les fragiles avant l'été
- si le variant anglais devient prédominant il n'est pas sûr qu'on ne doive pas confiner
- on devrait arriver au million de vaccins fin janvier
- il n'est pas sûr qu'on vaccine tous les fragiles avant l'été
- si le variant anglais devient prédominant il n'est pas sûr qu'on ne doive pas confiner
Sachant que le variant anglais #B117 va devenir prédominant en France entre mi février et mi mars selon les modélisations de @Inserm / @institutpasteur, c'est donc une question de temps... confiner AVANT, par exemple au moment des vacances scolaires serait la meilleure solution
@FrankNBraun @ulfposh @welt Das sind Maßnahmen, die man nutzen könnte, wenn der Datenschutz nicht dagegen stünde. Und vor allem, wenn wir eine kontrollfähige Inzidenz (<50) hätten. Bei der aktuellen Inzidenz und mit den noch gefährlicheren Mutationen vor der Brust sind Ihre Empfehlungen tödlich. (1)
@FrankNBraun @ulfposh @welt Die um 50-70% höhere Infektiosität von #B117 erfordert ein noch niedrigeres R, und die nochmals erheblich höhere Infektiosität der Varianten mit der Mutation #E484K, die auch Prä-Infizierte und Jüngere, nicht Vorbelastete betrifft, macht weitere, erhebliche (2)
@FrankNBraun @ulfposh @welt Kontakteinschränkungen bis auf ein R <0,7 erforderlich. Vulnerable Gruppen zu schützen bedeutet beileibe nicht nur "Heime schützen" - 20 Mio. sind vulnerabel, aber nicht in Heimen, da jünger oder jung. Die Diskussion übersieht die chronisch Kranken, die Krebskranken, (3)
Meanwhile in #France,
"the peak of this second wave is over"
(according to the President in his Adress to the Nation):
"the peak of this second wave is over"
(according to the President in his Adress to the Nation):
Wait... "the peak is over" doesn´t mean "it´s back to normal"!
Confinement will only fall on December 15,
if there´s less than 5.000 new cases a day.
(today it´s ~9.000).
France is disappointed.🙁
Although they certainly can make it happen.
Confinement will only fall on December 15,
if there´s less than 5.000 new cases a day.
(today it´s ~9.000).
France is disappointed.🙁
Although they certainly can make it happen.
Meanwhile in #Switzerland:
(excess mortality of the second wave is significant)
Good news: fastest decrease in infections happens in the worst hit areas now.
(excess mortality of the second wave is significant)
Good news: fastest decrease in infections happens in the worst hit areas now.
As #COVID19 cases are found to spread, #Melbourne (city of ~5 million) tries to contain them by going into #Lockdown.
(The interview features the idea of a dedicated #Quarantine building - that would actually help, I guess)...
(The interview features the idea of a dedicated #Quarantine building - that would actually help, I guess)...
"People acting as if the pandemic was over was 'not the answer, it is part of the problem' ".
"The virus had leaked from postcodes already under the stay-at-home orders to other parts of #Melbourne."
(and beyond, it is feared).
"The virus had leaked from postcodes already under the stay-at-home orders to other parts of #Melbourne."
(and beyond, it is feared).
Due to #Melbourne's outbreak, neighbouring South Australia is about to completely close it's borders to #Victoria.
(Nearly) no exceptions. And those essential few who are allowed in, will have to wear facemasks the entire time...
(Nearly) no exceptions. And those essential few who are allowed in, will have to wear facemasks the entire time...
Vorpommern-Greifswald district (where rejections of #Gütersloh residents took place, yesterday)
has specific rules:
"Those who return from international risk areas (out of Germany) or whose Corona-Warning App has alerted them, need to report to authorites"
kreis-vg.de
has specific rules:
"Those who return from international risk areas (out of Germany) or whose Corona-Warning App has alerted them, need to report to authorites"
kreis-vg.de
In fact, Mecklenburg-Vorpommern's Corona-ordinance really prohibits entry of people from international risk areas AND german risk areas as well.
It's just not prominently featured on their websites.
(Overlooked that myself, hence deleted earlier tweet)
landesrecht-mv.de/jportal/portal…
It's just not prominently featured on their websites.
(Overlooked that myself, hence deleted earlier tweet)
landesrecht-mv.de/jportal/portal…
People from #Gütersloh district may have to scrap all their holiday plans anyway...
An official #Lockdown is just being announced for the entire district.
(for one week, as of now)
An official #Lockdown is just being announced for the entire district.
(for one week, as of now)
