Discover and read the best of Twitter Threads about #melanoma

Most recents (7)

Here’s a closer look at TIGIT and its potential in #cancer therapy. This target is primed to gain more traction in immuno-oncology this year. (Thread below)

Key players developing anti-TIGIT therapies are $RHHBY $MRK $BMY $RCUS $ALPMY $BGNE $CGEN $SGEN $MREO $IVBXF & @iTeosTx
TIGIT is an inhibitory receptor expressed by activated T-cells, T-regs & NK cells

- Ligand for TIGIT (PVR) is expressed in multiple tumor types
- Activation suppresses T-cell activity
- Upregulated during PD-1 blockade

@Cancer_Cell paper (open access):…
A key TIGIT question is the role of FcƔR and antibody-dependent cell-mediated cytotoxicity (ADCC).

$RHHBY & $MRK support FcƔR ADCC benefit due to T-reg depletion & myeloid cell reprogramming. $RCUS states the opposite as this ADCC activity may also deplete T-effector & NK cells.
Read 29 tweets
Here's my latest* update to my vetted collection of Twitter Disability and Chronic Illness hashtags. Please share it!

Thank you :-) Graffiti background. Foreground in black letters on a  white background to the left reads “Twitter Disability and Chronic Illness Hashtags”<br />
This collection is current as of 01.30.20, previous Twitter update 09.11.19.

There's a PDF version coming up this weekend, to be posted to my Kofi profile. I'll add the link toward the end when it goes up, after the questions, where you can also sign up for email updates.
This version has added

- community suggestions,
- mental health hashtags,
- Medical crowdfunding hashtags,
- and a section for cancer-related hashtags.
Read 84 tweets
Hey #tipsfornewdocs #medtwitter folks! I wanted to review side effects of immune checkpoint inhibitors (ICIs) for a non-#oncology audience. Immune-related adverse events (irAEs) present across all medicine specialties so we are all in this together. 1/x
The most common ICIs are against PD-1 (e.g. nivolumab, pembrolizumab) and PD-L1 (e.g. atezolizumab, durvalumab). I use a blanket term “PD-1” throughout. Anti-CTLA-4 (ipilimumab) is a distant second; often in combo or directly after PD-1 in #melanoma #lung #kidney cancers. 2/x
They have led to pharma riches and Nobel Prizes and lots of TV commercials because they work really well for some patients. People with advanced #melanoma, #lcsm etc who used to live ~1 year now can hope to live for several years or more. 3/x
Read 17 tweets
In honor of #skin #cancer awareness month, here's a #tweetorial on #SKINCANCER!

There is SO much we could talk about, so I'm going to keep it basic. #Dermtwitter, please add more!

#MedEd #FOAMed #dermatology #medtwitter @aadmember #dermatologia pc: @dermnetnz & @aadskin
There are many types of skin cancer, but we'll focus on the big 3 in this #thread. We'll discuss basal cell carcinoma (BCC), Squamous cell carcinoma (SCC) & melanoma. The first two are types of "non-melanoma skin cancer (NMSC)," or more aptly named "keratinocytic carcinomas."
BCCs are the most common cancer diagnosed. Classically described as "pink pearly papules," they often have "arborizing" (tree-like) telangiectasias. But, they don't always have to look classic. The 1st pic is the classic, but the others are also BCCs (superficial & pigmented)!
Read 19 tweets
Lifetime risk of getting #melanoma for an American is high. This is particularly true for caucasians. One in 38 white Americans will get skin cancer during their lives. Stats are better for African-Americans at 1:1000, but worse for Latinos with stats showing 1 in 172.
There is a paucity of research on cannabis & cancer. For skin cancers, there are not any clinical trials investigating the question of #cannabis medical efficacy. Rick Simpson was one of the rare patients whose basal cell carcinoma metastasized.…
Read 6 tweets
Tuesday was the prelim. Thursday is the main event.
Right now, I am resting between sprints.
Trying to breathe.
Inhale. Pray. Exhale.

The days and weeks ahead are going to be another life test.
(Pretty sure I learned this lesson already, but, okay, universe.)
The outpouring of concern and love I have received on here has been so far beyond anything I could have imagined. I feel so supported and strengthened by all these messages--too many for me to respond to all of them, but deeply, deeply appreciated.

Thank you so VERY much.
There are currently 17M Americans with #cancer.
41% of us will get some form of cancer in our lifetimes.
That's nearly half of us.
Everyone knows someone with cancer.
So we have to be vigilant and we have to take care of ourselves--lower that stress, first and foremost.
Read 10 tweets

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