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Eric Topol
@EricTopol
, 3 tweets, 6 min read Read on Twitter
Helping the outcomes of 34% of patients w/ #cancer (who failed Rx) by whole genome sequencing and sharing data for off-label drug use: lessons from the Netherlands
nature.com/articles/s4158… @Nature #openscience #immunotherapy
@nature That was the 1st of a 3-fer on WGS for #cancer today
Value of whole genome sequencing for 254 patients w/ triple-negative breast cancer nature.com/articles/s4159… @NatureMedicine by @SerenaNikZainal @Cambridge_Uni @MRC_CU @lunduniversity and collaborators
@nature @NatureMedicine @SerenaNikZainal @Cambridge_Uni @MRC_CU @lunduniversity 3rd on paired tumor, germline DNA + RNAseq, clinical data in 500 patients to expand clinical trial options nature.com/articles/s4158… @NatureBiotech
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More from @EricTopol see all

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Eric Topol
@EricTopol
Impressive life science research that would not have been possible w/o machine vision #AI (that they developed)
secure.jbs.elsevierhealth.com/action/getShar…
400,000 fly videos-> whole #brain maps for gene expression + anatomical basis of 14 traits @CellCellPress @HHMIJanelia Kristin Branson 1/3
@CellCellPress @HHMIJanelia Beyond DeepLabCut, new #AI software to do that is DeepPoseKit elifesciences.org/articles/47994… @eLife #deeplearning from flies to giraffes 2/3
@CellCellPress @HHMIJanelia @eLife This week @NatureNews reviewed these #AI machine vision tools: "Deep learning powers a motion-tracking revolution"
by @robertakwok #openaccess
nature.com/articles/d4158… 3/3
Read 3 tweets
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Eric Topol
@EricTopol
Aftershock on aftershocks.😉
Remember the recent @nature paper using deep learning #AI to predict aftershocks after an earthquake?
Well, this one under the heading "Matters Arising," says it ain't so, by @ArnaudMignan and Marco Broccardo
nature.com/articles/s4158…
@nature @ArnaudMignan Aftershock after the prior aftershocks
nature.com/articles/s4158…
response from the original paper's author, along with original paper and @NatureNV nature.com/magazine-asset…
@nature @ArnaudMignan @NatureNV And, likewise, going back to the earthquakes:
"we demonstrate that simpler models seem to offer similar predictive powers, if not better ones."
by @ArnaudMignan and @MarcoBroccardo
arxiv.org/abs/1910.01178 @arxiv #AI
Read 3 tweets
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Eric Topol
@EricTopol
On red meat: "this is sure to be controversial"
5 systematic reviews, including 100's of studies, millions of participants, RCTs, show little evidence for adverse #cancer or cardiovascular outcomes
annals.org/aim/fullarticl…
@AnnalsofIM ★editorial- 6 papers
@aaronecarroll @DrTiff_
@AnnalsofIM @aaronecarroll @DrTiff_ @IUMedSchool The 6 papers/guidelines are all #openaccess
annals.org/aim/latest
This does indeed fulfill the Dunning–Kruger effect
(The less people know, the more they actually think they know) owing, in part, to poor methodology/analysis/bias of #diet studies
@AnnalsofIM @aaronecarroll @DrTiff_ @IUMedSchool What a wacky day for #diet research:
1. Red meat may not be so bad for health risk, after all? (I haven't had for ~40 yrs)
2. ⬆️vegetarian diet by increasing choices; see @PNASNews by @eegarnett89 @MarteauTM
3. Cooked plant food ->⬆️ gut #microbiome diversity @NatureMicrobiol
Read 5 tweets

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Steven Chen
@DrStevenTChen
Syphilis! RMSF! Hand-foot mouth!

Slow down there, Tiger! Let's dive deeper into:

ACRAL RASHES - a #tweetorial/#medthread
(aka rashes on the "palms and soles" - kind of 😉).

#MedEd #FOAMEd #medtwitter #dermtwitter #dermatology #dermatologia pc:@dermnetnz
1/
No where else on the body does a rash evoke more of a knee-jerk differential. That's not wrong per se, as we all learn this in med school, but it's more complicated then starting doxycycline and checking an RPR!

Let's start with a definition - what does "acral" actually mean?
2/
Technically, "acral" just means our distal body parts. So while we often think of palms and soles, it's actually inclusive of the whole hand, the whole foot, ears, and some include even the nose!

I actually didn't learn this until #derm residency, which was shocking to me.
3/
Read 20 tweets
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Windthin ~ Savage Rebel Scum & Snark Jedi🇵🇷🌊
@windthin
1/16 It has begun. The GOP is spinning that the sole transcript Trump says he will release is more important than the #WhistleblowerComplaint as a tactic to insist everything should ride on this one supposed piece of evidence.

#ImpeachTrump #ImpeachmentParty #UkraineTranscript
2/16 All reports indicate this was a months-long conspiracy Trump and Giuliani were engaged in, subverting & bypassing officials who tried to stop them.

A single call does not BEGIN to give an accurate depiction of the events that lead up to this. washingtonpost.com/national-secur…
3/16 And Trump already has a shady history with releasing information.

Forget the obvious like his tax returns, school grades, and secret meetings with Putin.

Actually, a reminder of those secret meetings:
Read 168 tweets
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Kay Hallsworth
@kay_hallsworth
Great to be able to attend #IIMEC14 today in London, a full agenda and not sure my brain will take it all in but I’m here with some of the giants in ME biomedical research. @Invest_in_ME
And the venue is amazing
Dr Ian Gibson - we will conquer #ME , one day you will all need other jobs because we will have solved it #IIMEC14
Read 66 tweets
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Q
@literallyjustq
A little thread, which I may come back to, for all those #technophobes who blame rise in #suicide on #socialmedia.

First: legit, what rise?
Second: The actual experts do not agree with you, and your fear-mongering is likely causing more harm than good.
cf. Thomas, K, and Gunnell, D. (2010). Suicide in England and Wales 1861–2007: a time-trends analysis. International Journal of Epidemiology, Volume 39, Issue 6, December 2010, Pages 1464–1475.
So, first the data, from #UK (above) and elsewhere (below).

Clearly if this epidemic was *caused* by a *single* factor it would permeate all societies with social media.

[Suicide Rates for Teens Aged 15–19 Years, by Sex — United States, 1975–2015, #USA]
Read 126 tweets
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Asher Wolf
@Asher_Wolf
Full house at the Ehlers-Danlos Society Conference at Macquarie University today: @LaraBloomEDS opening the event
"Hypermobile EDS is probably more prevalent than diagnosed." #AustEDSConf18
. @LaraBloomEDS talks about a doctor at a conference who gave a talk denying EDS is real, despite the genetic data. #AustEDSConf18
Read 118 tweets
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Jason Wright
@jasonawright7
1. The sleeping giant is slowly awakening to the corruption that is enslaving us all.

Once this giant has fully awoken we shall be unstoppable.

Public awakening is their greatest fear.

#QAnon @POTUS @realDonaldTrump
2. It’s essential that #WeThePeople understand how #Corruption in the pharmaceutical industry has a stronghold on people.

#QAnon @POTUS @realDonaldTrump
3. This long & detailed thread will shine light on corruption in the vaccine and cancer industry.

These are complicated & touchy parts of the #DeepState rabbithole for obvious reasons but facing the #Truth is very important.

The truth shall set everyone #free.

#QAnon @POTUS
Read 109 tweets

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