Discover and read the best of Twitter Threads about #parkinson

Most recents (24)

Goed punt. #stikstof is niet alleen slecht voor de natuur maar ook gewoon voor onze #gezondheid. Arts Ignas van Bebber laat zien dat we met het milieu ook onszelf verziekt hebben.
Dit probleem kennen we natuurlijk ook al langer. Er is veel te doen geweest over de #geitenhouserij. Daar zijn ook doden bij gevallen vanwege #qkoorts. De #ggd adviseert afstand te houden ggdghor.nl/actueel-berich…
En #vogelgriep uit de #pluimveehouderij springt nu nog niet over op mensen maar die risico's worden met de dag groter volgens virologen. De sprong naar zoogdieren is immers al gemaakt eenvandaag.avrotros.nl/item/risicos-v…
Read 8 tweets
Como hoy es el #diainternacionaldelparkinson, voy a abrir un #Neurohilo para hablaros de la segunda enfermedad neurodegenerativa más frecuente:
#Neurocosas #Parkinson #Cerebro #Neurociencia #ParkinsonDay #Parkinson Image
Antes de empezar con la neurociencia vamos con un poco de historia: la enfermedad fue descubierta por el médico londinense James Parkinson, quien en 1817 publicó "Essay on the Shaking Palsy" (Ensayo sobre la parálisis agitante)…
…donde describe la mayoría de los síntomas clásicos motores presentes en la enfermedad de Parkinson.
Read 41 tweets
🏆 In dieser Woche schaffte es eine Recherche von @BR_Recherche und @WDRinvestigativ zur Hacker-Gruppe “Snake” auf den ersten Platz der meistgeklickten Artikel im DICOVERS Newsletter. Top 3 der meistgeklickten Artikel der Woche im DICOVERS News
Seit mehr als zwei Jahrzehnten werden die #Hacker von „Snake“ weltweit beobachtet. Ihnen wird auch der Angriff auf das System des Auswärtigen Amts von 2017 zugeschrieben. Artikel dazu von @FlorianFlade, Lea Frey und @hatr in der @tagesschau.
tagesschau.de/investigativ/b…
Mittlerweile zeigen zahlreiche Studien, dass #Pestizide das Risiko, an #Parkinson zu erkranken, erhöhen können. Vor deutschen Gerichten haben Betroffene aber dennoch kaum eine Chance. Artikel dazu von @LuisaBillmayer@danieldrepper und @katrin_langhans.
buzzfeed.de/recherchen/win…
Read 5 tweets
Da es gerade das #Tabuthema während der #Nachdurchseuchung und #Kinderdurchseuchung ist. Einige wichtige Infos zu #LongCovid & #LongCovidKids die viele nicht wissen die in dem Thema nicht drin sind:
1.) Long Covid bedeutet #nicht dass die Covid Symptomatik nur schwer abklingt
1x
oder eine längere Rekonvaleszenzphase bei schweren Verlauf. #LongCovid Risiko ist vollkommen entkoppelt, von der individuellen Verlaufsschwere. Große Studie aus England zeigt dass Long Covid Betroffene zu 90% während Covid nicht ins Krankenhaus mussten,
2x
Auch zwischen denen die es richtig weg gehauen hat und denen die nur wenige respiratorische Symptome für kurzen Zeitraum hatten keinen Unterschied. Risiko scheint von Verlaufsschwere fast #entkoppelt. Wenn eine Familie #Covid hatte
3x
Read 26 tweets
Immaginate di svegliarvi e ricevere un messaggio da vostro marito:”Dora, quando torni?! C’è qui una donna! Una ladra! Ora chiamo i Carabinieri!”
Vi girate e lo guardate digitare. Vi rivolgete a lui, ma vi aggredisce e vi chiama “Ladra!”
#Alzheimer
Di notte sentite il vuoto nel letto, e correte a cercarlo; è in bagno da ore, in piedi, in ipotermia, immobile davanti al panorama invernale dell’undicesimo piano. “Preparati Dora, sta arrivando la seggiovia”.
#Alzheimer
Alla tv c’è la premiazione degli atleti olimpici. Immediatamente corre ad infilare le scarpe. Le allaccia guardando lo schermo.
-Ma che fai? Non usciamo ora.
“Se mi chiamano, come ci vado sul podio? Scalzo?!”
#Alzheimer
Read 10 tweets
We identified common #mtDNA variants in 16K British individuals with EUR ancestry from the INTERVAL study, performed the first large-scale assoc study between #mtDNA variants and ~5000 molecular traits that directly tag metabolic processes. 2/n
We found and replicated significant associations between #mtDNA variants in Haplogroups Uk (found in 10% of the EUR population) and H3 (2%) and levels of N-formylmethionine (fMet), an amino acid known to be important for intra-mitochondrial translation. 3/n
Read 12 tweets
💡 Welche #Startup-Teams konnten den @cedus_hhu-Ideenwettbewerb für sich entscheiden?
Im Live-Finale am 7. Juli konnten sich die folgenden Konzepte unter insgesamt 34 Einreichungen durchsetzen:
Kategorie I: Ideen von Studierenden
Der mit 800 Euro dotierte 1. Platz ging an „WalkFlow“ (#KI-gestützte App für #Parkinson-Erkrankte), der 2. Platz mit 500 Euro und der Publikumspreis gingen an „Just Bowlin“ (Automaten für gesunde Mahlzeiten)...
und Platz 3 mit 300 Euro erhielt „Das Fitnesscenter für Zahnis“ (Leichterer Zugang für Studierende der #Zahnmedizin zu Phantomkopfräumen).
Read 8 tweets
Ready for a quick and easy tutorial on how to develop a #strength training treatment plan for your patients - such as those for #EMST, #CTAR, #IOPI? 💪🙋‍♂️ Check out the below thread along with an accompanying example using #expiratory #muscle #strength training #EMST Image
First, measure the patient’s 1-repetition maximum (RM) by determining where they "max" out on a resistance-based exercise💪📈
Second, determine the desired strength training intensity level (i.e., low, moderate, high). For most of our elderly and/or rehab patients, we will use moderate intensity. For neuromuscular diseases (e.g., #ALS), current research suggests to consider a low intensity exercise.
Read 10 tweets
For reasons not yet fully understood, the incidence and prevalence of #Parkinson's disease have risen rapidly in the past two decades.

This new Seminar suggests how personalised management of the disease can be optimised. Read: hubs.li/H0KXpjV0 #WorldParkinsonsDay
The motor features of #Parkinson’s disease are hard to miss. This video shows the complete motor examination of people with recently identified Parkinson’s disease. #WorldParkinsonsDay
Currently, no therapy can slow down or stop the progression of #Parkinson’s, but promising disease-modifying strategies are being tested, informed by new insights in genetic causes & mechanisms of neuronal death.

Read: hubs.li/H0KXpjV0 #WorldParkinsonsDay
Read 3 tweets
#LongCovid bei Kindern
Eine Zusammenfassung von Studien und Meldungen:
Klinische Merkmale, Aktivitätsniveaus und psychische Gesundheitsprobleme bei #Kindern mit LongCovid
Die bislang umfangreichste Studie über #LongCovid von 510 betroffenen #Kindern: Clinical Characteristics, Activity Levels and Mental Health Problems in #Children with Long COVID: A Survey of 510 Children
#LongCovid in England: Bericht über #Kinder die nach milden COVID-Verläufen unter #Atemnot, #Gelenkschmerzen und #Schwindel leiden. Das chronische Erschöpfungssyndrom ist bei einigen so stark, dass sie auf einen #Rollstuhl angewiesen sind #twlz #kmk
bbc.com/news/uk-englan…
Read 140 tweets
#SalonSAP | 📣Auxiliaires de vie sociale, aides-soignants, infirmiers, aide-ménagères : vous accompagnez des personnes à domicile ou en résidences autonomie ?

Retrouvez des recommandations et outils pour vous accompagner au quotidien ⤵ Image
#SalonSAP | Maladie d’Alzheimer, de Parkinson, à Corps de Lewy... Vous accompagnez à domicile une personne atteinte de maladie neurodégénérative

Retrouvez des outils pour adapter vos pratiques professionnelles 👉 has-sante.fr/jcms/p_3193048… Image
#SalonSAP | Maladies neurodégénératives - ex. #Parkinson : un accompagnement à domicile spécifique

▶ La minute RECO avec Véronique Monterrat, responsable de SSIAD : "Nos intervenants à domicile ont besoin d’outils et de repères"

Les recommandations 👉 has-sante.fr/jcms/p_3193048…
Read 5 tweets
We are thrilled to share our #preprint "Atlas of genetic effects in human #microglia transcriptome across brain regions, aging and #disease pathologies"!
Work led by @lopeskp @JackHumphrey_ #Gijsje and others from #deWitte and #Raj Lab (@towfiqueRaj)
t.ly/pZqQ 1/23
Here, we describe the Microglia Genomic Atlas (#MiGA) project. A genetic and transcriptomic resource of 255 primary human microglia isolated from 4 brain regions of 100 donors with neurodegenerative and psychiatric disease and controls. 2/23 Image
We performed the following analysis: I) age-related (the age of donors range from 21 to 103 y.o! II) brain regional heterogeneity ; III) expression and splicing quantitative trait loci #eQTL & #sQTL. 3/23
Read 23 tweets
L'imposture @Matadon_

Ou pourquoi il faut arrêter de croire ce qu'il racontre sur l'#agriculture, la #biodiversité et d'autres sujets.

Un thread en 22 tweets sur un #NoFakeScience qui falsifie la science.
Version longue : factsory.org/2020/imposture…
Souvent pris en référence sur les sujets #agriculture ou #biodiversité, Matadon dit en fait tout et son contraire, ne corrige pas ses erreurs, fait tout pour critiquer démesurément le #bio et approuver sans limite le #glyphosate et les #OGM.
Il prétend que le #glyphosate est meilleur pour la biodiversité du sol que le bio, en utilisant une étude qui ne dit pas cela. Il pare le bio de tous les maux. Vante les mérites d'un pesticide dangereux, etc, etc.
Read 22 tweets
Paciente varón, 59 años, dx de depresión de dos años de evolución en tratamiento por psiquiatría. Poca respuesta. Está irritable y apático. Se nota mas lento y menos diestro tocando instrumentos (es músico) cosa que atribuye al tratamiento para la depresión. Ha engordado > 15kg.
Tiene hiposmia desde hace 5 años + trastorno sueño REM. Trae RM con un pequeño foco de gliosis frontal.

En la exploración neurológica destaca:
Marcha con disminución de braceo bilateral, cierta anteflexión; cierta hipofonía, ligera disminución de amplitud de los pasos (sigue)
reflejos de enderezamiento 1/4; oculomotricidad normal; hipocinesia global 2/4; rigidez predominio izquierdo 2/4. ROTs normales. Coordinación normal.
Read 16 tweets
Check out this interview I did w/ @resiapretorius 👉 Resia + team have published dozens of papers detailing how inflammatory products created by #bacteria/#viruses in human blood can drive clotting, red blood cell deformability, vasculature problems etc: microbeminded.com/2020/08/06/int… Image
2/ Conditions studied by Resia and team include #Alzheimer’s + #Parkinson’s. For example they identified toxic gingipain proteins created by oral #pathogen p. gingivalis in the blood of Parkinson’s patients, and showed how the gingipains can increase hypercoagulation ImageImage
3/ I am truly excited about the fact that we are working to send her team #ME/CFS and #PTLDS (chronic #lyme disease) blood samples that they will analyze for many of the same issues 🙌
Read 3 tweets
On #WorldBrainDay, the Neuronet programme is celebrating @IMI_JU's public-private partnerships in #neurodegeneration research; from fundamental science to clinical studies, data analysis to knowledge mining & beyond.

Keep your eyes peeled! #WeAreNeuronet
2/20 @bwfalcon, now a group leader at @MRC_LMB, worked on the structure of Tau filaments @imprind, showing how they are misfolded in the brains of people with #neurodegenerative diseases.

Read about his work here: bit.ly/IMPRIND-falcon #WorldBrainDay
3/20 #WorldBrainDay 2020 is dedicated to raising awareness of #Parkinsons disease. There are currently no disease-modifying treatments for mild cognitive impairment in PD; the #PD-MIND project aims to test a new drug to treat this condition. Find out more:bit.ly/PD-MIND
Read 21 tweets
Ever wondered if and how #recombination of #retroelements contributes to #somatic #mosaicism? Read about it in our new pre-print:

Non-allelic homologous recombination of Alu and LINE-1 elements generates somatic complexity in human genomes. biorxiv.org/content/10.110…
1/ Background: pathogenic non-allelic homologous recombination (NAHR) of Alu and LINE-1 has been found in several genomic disorders and #cancer types. We thought this could be just the tip of the iceberg of a physiological recombinogenic activity of retroelements.
2/ The excellent Martin Frith developed a fresh pipeline to identify non-allelic homologous recombination (NAHR) in short and long-reads libraries: 🦖TE-reX🦖. It smartly focuses on split reads that join repeat elements at homologous positions.
Read 11 tweets
Ooof interesting! This team found Ljungan #virus (LV) antigens in autopsied #brain tissue from the hippocampus region of 18 #Alzheimer’s brains. No LV antigen was identified in any of their 11 age-matched control brains: ncbi.nlm.nih.gov/pmc/articles/P…
2/ The LV virus antibodies reacted with #neurons and #astrocytes and also showed distinct positive reaction in the #amyloid/neuritic plaques. The team thinks the findings indicate LV #virus may persist in the Alzheimer’s brain
3/ Here’s an image from one of the #Alzheimer’s brains. The red stain visualizes presence of LV viral antigen in neurons, astrocytes + #glial cells. In Panel C, an amyloid/neuritic plaque is shown staining positive in the glial compartment + in dystrophic neurites Image
Read 4 tweets
Awesome study used mice + human brain organiod model to show #COVID-19 can infect the CNS/#brain, where it specifically infected radial #glia, neural stem cells + #neurons. The #virus altered the #metabolism of the neurons it infected + cld use neuron cell machinery to replicate
2/ It’s not surprising that #COVID-19 can infect neurons given the nasal cavity is connected to the #CNS via the cribriform plate, olfactory epithelium + #nerve. This led the team to state that “the brain should be considered a high-risk organ system upon #respiratory exposure”
3/ The team also showed that, at least in some #COVID-19 patients w/ #neurological symptoms, there is a robust antibody response to the #virus in the #cerebrospinal fluid (CSF). In fact, CSF-containing antiviral #antibodies blocked COVID-19 infection in brain organoids
Read 6 tweets
Check out the latest preprint from the lab on "Integration of #Genomic & Multi-tissue #proteomic data in neurodegenerative diseases" lead by @chengran2020 @WUSTLdbbs in @ccrugom lab at @WUSTLmed supported by @cziscience via @medrxivpreprint medrxiv.org/content/10.110… #tweetorial ⬇️
This is the first #proteomic study that uses high throughput pQTL in neurological relevant tissues to identify novel genetic loci regulating protein levels, which will improve our understanding of the biology of #Alzheimers, #Parkinsons, & other neurodegenerative diseases
We identified hundreds of novel pQTLs in CSF, plasma, & Brain linking novel genes, biomarkers and drug targets with #Alzheimers, #Parkinsons
Read 10 tweets
Un scientifique change d’avis si les faits lui donnent tort .... quel que soit son statut

Petite histoire personnelle : allez je vous la fais courte.

Il y a une dizaine d'année, j'étudiais encore et encore le #cuivre en biocides et #pesticides
Outre le fait que pour dériver une DJA et une AOEL sur un oligo-élément, tout allait bien. Juste un petit questionnement sur le passage cutané et l'évitement du premier passage par le foie, mais le #cuivre, élément métallique, n'est pas sensé pénétrer facilement la peau.
Autre questionnement, les impuretés pourries #plomb, #cadmium, #arsenic, #nickel mais en quantité faible donc a priori pas de soucis.
Read 14 tweets
NEW: “When does postural instability appear in monogenic parkinsonisms? An individual-patient meta-analysis” in The Journal of Neurology.
A 2-year effort with @LucaMarsili1 @andrea_sturchio @Dr_Murli_Mishra @DrAlfonsoFasano @nachogenePD @Marcelokauffman @AlbertoEspay
THREAD 🧵
LINK: link.springer.com/article/10.100…

Monogenic parkinsonisms are very different from one another. Not only on the severity of parkinsonism, but also on cognition, behavioral, and autonomic function.
(See a nice review ⬇️ sciencedirect.com/science/articl…)
A critical marker of disability is postural instability🚶➡️🧑‍🦯➡️🧑‍🦽, which leads to falls, and increased morbidity and mortality. The frequency and time-to postural instability in different monogenic parkinsonisms remained unknown.
Read 16 tweets
A short thread on Tory rotter Cecil Parkinson, illustrating why the Conservative Party must be *destroyed* to save the country… (pic shows him with Mrs Fascister in 1983). 😖✊🇪🇺🇻🇳 #ToriesOut #cad #ToriesLie #COVID19 #Parkinson #rotter #ToryShambles
Parkinson was a chartered accountant, and made a pile of money from establishing Parkinson-Hart Securities in 1961. He then entered Parliament in 1970; a normal career path for a Tory obsessed with money & power… 🙄 #ToriesOut #greed #gross 🇪🇺🇻🇳
As is extremely well-known, Parkinson had an affair with Sara Keays, his secretary in Parliament. He resigned his Cabinet post in October 1983, when news of her pregnancy became public. 😐✊🇻🇳🇪🇺 #ToriesOut #hypocrites #liars #ToryShambles
Read 17 tweets
👏🏼WOW. Medical Detection Dogs plans to train dogs to detect the odor of #coronavirus. The charity has already trained dogs to detect malaria, #cancer and #Parkinson's.

Dr Guest: "In principle, we're sure that dogs could detect #COVID19."

@MelissaJPeltier
bbc.com/news/uk-englan…
Dogs have previously been trained to detect other viruses.

Major issue is to ensure the SAFETY of these talented pups.😷

#coronavirus #COVID19
pubmed.ncbi.nlm.nih.gov/26779494/
My brother texted me about this approach last week....so cool to see these amazing dogs put into action to help detect #COVID19.

Safety of these wonderful pups must be carefully preserved!
Read 3 tweets

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