Thread by @nxtstop1

Thread: Decreasing muscle mass in aging: The harmful effects and how to counteract ––

Tags: #sarcopenia #aging #ageing #HealthyAging #MSKover50 #resistance training, #weights #physicalmobility #muscle, #protein
#osteoporosis #bone #fracture #falls

Image: iofbonehealth.org/what-sarcopenia

Thread: 🔽muscle in #aging ––#Sarcopenia RX, prevention –––

#MSKover50 #resistance #physicalmobility #osteoporosis #bone #fracture #falls

Lifespan vs. Healthspan: Why We Need Muscle for #HealthyAging.
runnersworld.com/health-injurie…
+
Live Strong and Prosper...
link.springer.com/article/10.100…

Thread: Sarcopenia in #Aging: RX, prevention –––
🔽
Biochemical Pathways of #Sarcopenia &Their Modulation by Physical #Exercise: A Narrative Review
frontiersin.org/articles/10.33… …
H/T @MathewPiasecki Tags: #MSKover50
LT: Key RE: onset & progress
RT: Rec. of @ACSMNews & @American_Heart

cont above.....#Sarcopenia #MSKover50 #aging
Altered signaling pathways…
♦️IGF-1
♦️TNF-a
♦️Myostatin
♦️Follistatin
♦️NAD+SIRT1,SIRT3
Leading to:
♦️Mitochondrial dynamics & biogenesis
♦️Protein degradation
♦️Protein synthesis
More info▶️frontiersin.org/articles/10.33…

Thread: #Sarcopenia in #Aging: RX, prevention–––
#MSKover50 #resistance #physicalmobility #osteoporosis #bone #fracture #falls
🔽
Dose of physical activity, physical functioning and disability risk in mobility-limited older adults: The LIFE study-RCT
Full: journals.plos.org/plosone/articl…

Thread: #Sarcopenia in #Aging: RX, prevention–––
#MSKover50 #resistance #physicalmobility #osteoporosis #bone #fracture #falls
From 1997–
sarcopenia.com/?m=199706
More than 20 yrs later, Americans r less fit, 🔼 BMI w/ more fat & less muscle. Choice: 🔼 healthy yrs or 🔼 sick yrs?

Cont, Sarcopenia in #Aging BGS Fall 2017 @GeriSoc :#Sarcopenia & Frailty

▶️ Definition

▶️ Community dwelling /67 yo! Incidence of #sarcopenia 4.6% men and 7.9% women! Lesson: Need early testing grip/ other strength

🔽 Grip strength assoc. w/ longer & more hospitalizations

More....Thread: Sarcopenia in #Aging
{from Brit MODIS Jan 2018:{Movement disorders in #ageing}
Speaker Miles Witham: #Sarcopenia, #Frailty & #HeartFailure ––
♦️knock on effects across multiple organ/ body systems
♦️absent other factors, frail w/same prognosis
cc #MSKAging

More...Thread: Sarcopenia in #Aging
Via Brit MODIS:Jan 2018 movement disorders in #ageing #aging
Symptom: Exercise Intolerance
Q: How much is due to #HeartFailure, how much to #sarcopenia?
{We know EX works with CHF}
Q: RX HF+Sarcopenia w/exercise rehabilitation too? #MSKAging

Thread: #Sarcopenia in #Aging: RX, prevention –
#MSKover50 #resistance #physicalmobility #osteoporosis #bone #MSKAging
🔽
Is #BMI An Indicator of A Healthy Weight? @ConversationEDU h/t @SandroDemaio
theconversation.com/we-asked-five-…
No. BMI doesn't distinguish fat vs muscle, more info 🔽

....RE: #BMI #Sarcopenia and #Aging and #Cognition/ #Dementia
Note phenomenon of 'Skinny Fat' –– looking thin but w/ little muscle, most is fat.
“Skinny Fat” in #OlderAdults May Predict #Alzheimers Risk neurosciencenews.com/skinny-fat-dem… @NeuroscienceNew
#MSKAging #GripStrength cc #AAIC18

Thread: #Sarcopenia in #Aging: RX, prevention
#MSKover50 #resistance #physicalmobility #osteoporosis #bone #MSKAging
#MuscleMass #BMI Vigorous #Exercise Is For All Ages/Stages
🔽
Sarcopenia – why you need to know what it is! Neat piece by @JulietMcGrattan
drjulietmcgrattan.com/2018/01/08/sar…

Thread: #Sarcopenia in #Aging
#MSKover50 #resistance #physicalmobility #osteoporosis #bone #MSKAging
MT @Brads_science
Is exercise a countermeasure 4aging? Can U help us?
In @FrontPhysiol, by myself, @DrLawrenceHayes, @HughesDC_Muscle &
Martin Burtscher- frontiersin.org/research-topic…

Just in case all this #Sarcopenia in #Aging seemed a bit much: Note 🔼muscle mass/strength brings incr.🔼 functional ability and 🔽 falls.
Look what grandma says:
Elderly Women Prefer Death to Suffering a #HipFracture
huffingtonpost.com/andrew-dudley/… Test all 65+:gait+strength. #MSKAging

........Perhaps quite sobering is the shocking statistic that 80 percent of women would prefer death than suffer a hip fracture and enter a nursing huffingtonpost.com/andrew-dudley/… via @HPLifestyle
Hear her interview.......
Tags: #Sarcopenia #MuscleMass #resistance training #MSKaging

Key: Test early ––in middle age, 50-70 ie #boomers BEFORE the last third of life when mom/dad/grandma/grandpa have already fallen. For #millennials + Gen X they need to exercise as if they're still in high school: adult sports, gym, on the trails and w/ weights. #100YearLifespan

Cont...#sarcopenia
QOL related to #fear of falling & #hipfracture in #olderwomen
bmj.com/content/320/72…
MQ"Nearly all women would trade off remainder life expectancy to avoid admission to a nursing home. 80% respondents said that they would rather be dead."

h/t @dementiarehab

More...Thread: #Sarcopenia in #Aging: RX, prevention
#MSKover50 #resistance #physicalmobility #osteoporosis #bone #MSKAging
#MuscleMass #BMI

MT @PhysioMeScience
Muscle as a paracrine and endocrine organ💪💪💪👀👀
sciencedirect.com/science/articl… …
{NB:paywall}

More.....On #Sarcopenia, Muscle and Aging #MSKover50
MT @edelphysio
Nice table of best exercise and forms of #physicalactivity for #muscle function, #bone health & #balance. Resistance training & ball sports tops🏋️‍♂️ ⚽️
Full article 👉research-information.bristol.ac.uk/files/15970469… … @CPNG_ISCP