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I am an infection doctor & scientist. My PhD is on unwanted effects of #antimalarial medicines, like chloroquine, on the heart. In overdose (taken too often or in excessive amounts) or in unapproved combinations, chloroquine, hydroxychloroquine & azithromycin kill #COVID19
I am an infection doctor & scientist. My PhD is on unwanted effects of #antimalarial medicines, like chloroquine, on the heart. In overdose (taken too often or in excessive amounts) or in unapproved combinations, chloroquine, hydroxychloroquine & azithromycin kill #COVID19
2/6
Important to use drugs at the right doses at which they have been properly evaluated, and as recommended by international guidelines from expert physicians and pharmacologists like @WHO. Antimalarials are typically dosed by body weight in kg.
who.int/docs/default-s…
Important to use drugs at the right doses at which they have been properly evaluated, and as recommended by international guidelines from expert physicians and pharmacologists like @WHO. Antimalarials are typically dosed by body weight in kg.
who.int/docs/default-s…
3/6
From global evidence review @WHO #malaria #drugsafety, co-chairs Prof Josep Brugada @hospitalclinic & Prof Sir Nick White @TropMedOxford, rapporteur @xhschan:
Chloroquine & hydroxychloroquine associated with sudden death in overdose @UMCGlobalSafety
who.int/malaria/mpac/m…
From global evidence review @WHO #malaria #drugsafety, co-chairs Prof Josep Brugada @hospitalclinic & Prof Sir Nick White @TropMedOxford, rapporteur @xhschan:
Chloroquine & hydroxychloroquine associated with sudden death in overdose @UMCGlobalSafety
who.int/malaria/mpac/m…
4/6
From systematic review @dr_haeusler @WWARN @xhschan @MORUBKK:
"the lethality of chloroquine in overdose ha[s]...caused considerable concern over [its] use in the treatment of malaria"
Safe at malaria doses, but higher doses unclear as untested.
bmcmedicine.biomedcentral.com/articles/10.11…
From systematic review @dr_haeusler @WWARN @xhschan @MORUBKK:
"the lethality of chloroquine in overdose ha[s]...caused considerable concern over [its] use in the treatment of malaria"
Safe at malaria doses, but higher doses unclear as untested.
bmcmedicine.biomedcentral.com/articles/10.11…
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From systematic review & meta-analysis @xhschan @yan2016npt @dr_haeusler @slphyx @djimdeab @siqueira__andre @ricprice99 in @PLOSMedicine:
To complicate things, fever (at least from malaria) adds to effect on heart rhythm of antimalarials
journals.plos.org/plosmedicine/a…
From systematic review & meta-analysis @xhschan @yan2016npt @dr_haeusler @slphyx @djimdeab @siqueira__andre @ricprice99 in @PLOSMedicine:
To complicate things, fever (at least from malaria) adds to effect on heart rhythm of antimalarials
journals.plos.org/plosmedicine/a…
