Thread by @TaNaishaJ

1/5 "The analysis revealed that older, #cognitively #healthy #brains showed similar amounts of #dissolvable, #non-#fibrillar #amyloid #protein as #brains of #Alzheimer’s #patients."

#aβ #Aβ #fibrils

gero.usc.edu/2023/01/05/new…

2/5 "But, as the researchers expected, the brains of #Alzheimer’s patients had higher amounts of #insoluble #Aβ #fibrils, the form of #amyloid #protein that aggregates to form the telltale “#plaques” seen in the #disease,..."

3/5 "... higher levels of #fibrillary #amyloid appear to be a better indicator of #poorer #brain #health."

4/5 "Rather than #Alzheimer’s simply involving increased production of #Aβ #protein, the more important issue may be a #reduced #ability to effectively clear the #protein and stave off the creation of #plaque-contributing #fibrillary #amyloid,..."

5/5 "These findings further support the use of #aggregated, or #fibrillary, #amyloid as a #biomarker for #Alzheimer’s #treatments,..."

alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…