Strategically: the key is the continued campaign to stop Iran’s entrenchment while preserving a friendly relationship with Russia.
Israel and Russia are not enemies and there’s no reason for a confrontation between them.
Russia knows that Israel can topple the Assad regime and stops short of that,due to Russian interests, among others considerations.
If Syrian crews operate them, Israel will know how to hit it. Russian air defense systems’ reputation will take a hit.
Faced with a dilemma whether to let an Iranian threat grow next door and taking a higher tactical risk and some inconvenience with Russia, its leaders will not sit on their hands watching.