Thread by @npure3

#InflammAging (chronic inflammation) may be the main force driving aging & #Omega3 derived Specialized pro-resolving mediators (#SPMs) have many potential #AntiAging benefits via resolution of inflammation/immunomodulation.
sciencedirect.com/science/articl…
nature.com/articles/s4157…

Systemic cytokines/#NFkB is responsible for aging in skeletal stem/progenitor cells (#SSPC's) but new research shows this aging can be reversed by modulating/decreasing these inflammatory factors
(likely most sustainably with high-dose #Omega3). pnas.org/content/116/14… #AntiAging

Is aging a "self-reinforcing loop" of increased systemic inflammation & oxidative stress already increasing at "middle age"? More & more evidence suggest that it is. #Omega3 may decrease both & be a powerful tool to break this vicious loop. nature.com/articles/s4159… #AntiAging

Great review: "The role of inflammation is emerging as the most important mechanism of aging—referred to as #Inflammaging—and plays an integral role in most explanatory models."
(#Omega3 derived #SPMs may offer new targets to manage chronic inflammation). frontiersin.org/articles/10.33…