My Authors
Read all threads
There is no proven effective antiviral drug for the treatment of #SARSCoV2

Several compounds are suggested for Rx of #COVID19. Based on the available in vitro and clinical data, which one is your preferred Rx, if available? #MayoIDQ references follow...

Several potential mechanisms: change in cell membrane pH, impairs viral fusion, interferes with glycosylation of viral proteins

#chloroquine and #redemsivir are active against SARS-COV2 in experimental models…
- Analogue of chloroquine
- Anti inflammatory effect

Hydroxychloroquine was more potent than chloroquine against #SARS-CoV2 in vitro.…
Protease inhibitor against HIV
Inhibits viral replication (in combo with ribavirin)

MIRACLE trial for #MERSCoV

Clinical data during the #SARS outbreak…
Lack of evidence based on this report…

A nucleotide-analog inhibitor of RNA-dependent RNA polymerases

Activity against many RNA viruses including #coronavirus in vitro and animal models (against #MERS Cov)…

A nucleotide-analog inhibitor of RNA-dependent RNA polymerases

Clinical: anecdotal only
Compassionate use - contact company
Enrol in clinical trials…
Anti-human IL6 receptor monoclonal antibody

Inhibits signal transduction by binding to IL6 receptor to reduce severity of lung inflammation

21-patient clinical data from China showed promise in #COVID19…
IL6 inhibitor

Clinical trials are being planned for selected #SARSCoV infection…
There is no proven effective therapy against #COVID19. We encourage participation in clinical trials.

Stay safe everyone! We will upload more data as they become available.

For now, please limit your exposure!
#socialdistancing #handwashing #flattenthecurve
Active against many RNA viruses

It was used in combination with lopinavir and ritonavir for Rx of #SARS…

However, in vitro data suggest that, by itself, it may not be active vs #SARSCOV2…

Antiparasitic with antiviral activity including #coronavirus

It vitro, it inhibited the 2019-nCoV at a low-micromolar concentration (EC50 = 2.12 μM; CC50 > 35.53 μM; SI > 16.76).

However, no in vivo or clinical data is available.…
Monoclonal antibody that neutralizes #SARSCOV2 has been reported as another experimental therapy…
Convalescent plasma has been proposed for prevention / treatment of #SARSCOV2.

This is an important effort that will need serological tests to identify individuals who have recovered with high antibody titers @ElliTheelPhD is leading our effort…
Active vs. many RNA viruses: inhibition of viral RNA polymerase

China: 80 participants with #COVID19
- “Earlier viral clearance / recovery”

Pharmaceutical Technology › newsWeb resultsFavipiravir by Fujifilm may treat Covid-19, say Chinese officials.
#Hydroxychloroquine #azithromycin for #COVID19

The results is reported: viral load decline is better with combination Rx
See link below (photo)…
#Kaletra #LopinavirRitonavir
- RCT, open label, n=199
- No difference in mortality and outcomes when compared to standard of care in patients with severe #COVID19…
Missing some Tweet in this thread? You can try to force a refresh.

Enjoying this thread?

Keep Current with Mayo Clinic Infectious Diseases

Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

Twitter may remove this content at anytime, convert it as a PDF, save and print for later use!

Try unrolling a thread yourself!

how to unroll video

1) Follow Thread Reader App on Twitter so you can easily mention us!

2) Go to a Twitter thread (series of Tweets by the same owner) and mention us with a keyword "unroll" @threadreaderapp unroll

You can practice here first or read more on our help page!

Follow Us on Twitter!

Did Thread Reader help you today?

Support us! We are indie developers!

This site is made by just three indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3.00/month or $30.00/year) and get exclusive features!

Become Premium

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal Become our Patreon

Thank you for your support!