My Authors
Read all threads
After 6 months of #lockdown and #lab shutdown I spent a full day 9 am-8 pm in lab doing experiments! New #grad students in #lifesciences: There is always light 💡 and #fluorescent images at the end of the tunnel! Filing a #patent on my #invention from #phd work soon @OrganOnAChip
This is an Organ on a Chip platform that enables mimicking #tissues and #organs in a high throughput manner! The main focus will be towards developing #mucosal organs with tissue resident #immune cells and lining #epithelial cells for #testing #COVID19 treatments #covidvaccines
I recently gave a talk at #oooc2020 organized by @GVNlab at @Columbia. In the talk I demonstrated the #ease of fabrication, #functionality, and #modularity of this platform.
We’re open to #collaborate with interested #researchers! Interested to learn more:
The #scalability at low cost is the biggest focus of our #technology #platform. By eliminating the use of #microfabrication we will acheive this goal along with providing the researchers around the globe 🌎 with the ability to produce the platform for specic #hypothesis testing
Each step in the #manufacturing can be automated. #Materials used in the platform are #commercially available. The platform is higy #modular as the #extra #cellular #matrix and the #cell types used can be specific to the tissue of organ in question. Here I manually add the #ECM
In the video above I am holding a #phone in one hand and adding the tissue matrix with the other. That along with the prior #timelapse movie suffices to show how easy it is to make these #organonchips. With the current dimensions I can put 3 of these on a standard glass slide
A very import characteristic of most organs #fluidflow can be introduced #ondemand. We hope that this will bring a paradigm shift in #microfluidic platform technology and enable widespread use of it by researchers and medical professionals in #thirdworldcountries @TwitterIndia
In terms of #instrumentation the mfg of #chips require a 1. Plotter cutter for cutting the #PDMS sheets into the shape of the channels, 2. An oxyegen/ozone #plasma cleaner to bind the peices permanently, 3. Microfluidic #pumps. These are #affordable and no need for a #cleanroom!
Finally during my #phdlife I used these as #gutoanachip for studying #mucus #hostmicrobe interactions in the #human #gut in real time! Manuscript and a @JoVEJournal paper coming soon.... My friend used to call it “💩 on a uF Chip”!! Still cracks me up every time I make these 😂😝
@threadreaderapp please unroll 🙏🏽
Missing some Tweet in this thread? You can try to force a refresh.

Keep Current with Abhinav Sharma, PhD

Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

Twitter may remove this content at anytime, convert it as a PDF, save and print for later use!

Try unrolling a thread yourself!

how to unroll video

1) Follow Thread Reader App on Twitter so you can easily mention us!

2) Go to a Twitter thread (series of Tweets by the same owner) and mention us with a keyword "unroll" @threadreaderapp unroll

You can practice here first or read more on our help page!

Follow Us on Twitter!

Did Thread Reader help you today?

Support us! We are indie developers!

This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3.00/month or $30.00/year) and get exclusive features!

Become Premium

Too expensive? Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal Become our Patreon

Thank you for your support!