Discover and read the best of Twitter Threads about #testtesttest

Most recents (23)

A metal ion orients SARS-CoV-2 mRNA to ensure accurate 2′-O methylation of its first nucleotide
The #SARSCoV2 #coronavirus is able to utilize the changes in metal ion concentrations to disguise itself in the human host body thus evading immune responses. Image
Efficacy of #clarithromycin on #COVID19 pneumonia without oxygen administration; protocol for multicenter, open-label, randomized-controlled, 3-armed parallel group comparison, exploratory trial #CAMECOVID
Japan Registry of Clinical Trials jRCTs071210011 Image
The influence of #HLA genotype on the severity of #COVID19 infection
A genetic link has been discovered explaining why some people catch #Covid but don't get sick. The gene is found three times as often in people who are #asymptomatic. Image
Read 199 tweets
🔝5 Concerns about #SARSCoV2 #Biology: A Call to Pause, Deliberate, and Revise Policy─This review is intended both as a basic resource and to initiate an open and critical dialog about SARS-CoV-2 biology for an independent and public call to action.…
Structural basis of ribosomal #frameshifting during translation of the #SARSCoV2 #RNA #genome
A unique feature of the SARS-CoV-2 genome controls protein synthesis and presents an "Achilles heel" of the virus. Image
Brainstem neuropathology in two cases of #COVID19: #SARSCoV2 trafficking between #brain and #lung
Neuropathologic evidence strongly suggests that the pathophysiology of COVID-19 related respiratory failure includes a neurogenic component. Image
Read 213 tweets
Reducing #COVID19 #Airborne #Transmission Risks on #PublicTransportation Buses
Wearing of #facemasks reduced the overall particle count released into the bus by an average of 50%, the dispersion distance by several feet and #aerosol particles by 84.36%. Image
🔝#SARSCoV2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis
#COVID19 can kill heart muscle cells, interfere with contraction. Details of how #coronavirus infects #heart: models of tissue damage may help develop potential therapies. Image
High-content screening of coronavirus genes for innate immune suppression reveals enhanced potency of SARS-CoV-2 proteins
196 protein products of seven coronaviruses: the genes encoded by #SARSCoV2 are generally more potent immune suppressors than others Image
Read 236 tweets
⚠️#Ocular #MRI Findings in Patients with Severe #COVID19: A Retrospective Multicenter Observational Study
All patients had nodules in the macular region, 8/9 (89%) had bilateral nodules, 2/9 (22%) had nodules outside the macular region. Screening needed. Image
⚠️🔝New-Onset #IgG #Autoantibodies in Hospitalized Patients with #COVID19
An international team of researchers studying COVID-19 has made a startling and pivotal discovery: The virus appears to cause the body to make weapons to attack its own tissues. Image
⚠️🔝Patterns of myocardial injury in recovered troponin-positive COVID-19 patients assessed by cardiovascular magnetic resonance
Damage to the heart found in more than half of #COVID19 patients discharged from hospital who show raised levels of troponin. Image
Read 235 tweets
1/ Very important to keep in mind that we've essentially reached #SARSCoV2 #COVID19 testing capacity in #Switzerland. Tests have plateaued but positivity is still >20%.

This makes it *very difficult* to read anything into the case numbers. I would urge caution with all analyses.
2/ There has been talk about hoping we can see signs of measures working by end of this week.

But, many cantons are restricting tests, lines are very long in places, & overall Switzerland can't really test more.

This makes it difficult to see whether restrictions are working.
3/ In the analogy where #SARSCoV2 testing is 'switching on the light' to fully understand the scope of the pandemic, #Switzerland has walked to the edge of where our lightbulb can illuminate.

At the cusp of darkness it's hard to see. Let's not make a leap of faith. #TestTestTest
Read 4 tweets
People are talking about *forward* and *backward* #ContactTracing #COVID19

What do they mean?

I made a case study for the @GOARN @WHO contact tracing group

A fictional contact tracer’s tale

My slides are here:…

Short thread (1/7) Forward and backward contact tracing for COVID-19, slideshow
Most #ContactTracing seeks contacts from 2 days before the infected person developed symptoms

#SARSCoV2 can be transmitted before symptoms emerge.
That is looking *forwards*

Who might the index case have infected?

Contacts in quarantine soon enough won’t infect others

Forward contact tracing can break onward transmission chains.

But it doesn’t find the source who infected the index case

To find the source, we need to go *backwards*

Index cases are more likely to have been infected by a source, who also infected others in a cluster

Read 7 tweets
Thread/ Colleges, testing, & why we need caution.

I am FAR LESS worried about the students. I worry about this -

"One major risk is that infections could spread to at-risk faculty and staff and those in the surrounding community."

The national figures that we have come to rely on are more reliable but subject to MUCH more challenging interpretation than at any time.

A LARGE percent (20% of Illinois in this article) of current tests are from colleges doing MASSIVE testing, in some cases. 2/8
This is reducing the positive rate, giving us a less reliable indicator. We know from hospitalization and death data a lot about infections that happened in early to mid August, and that news is good. But what is happening NOW? I don't think we know enough. 3/8
Read 8 tweets
💡Simple at-home #TestTestTest for the #coronavirus, some that involve spitting into a small tube of solution, could be the key to expanding testing and impeding the spread of #COVID19. @US_FDA should encourage their development.…
💡Instead of running #TestTestTest for each person, laboratories could #PoolTest small groups of people and analyze them all at once (#PoolTesting). For the ones that come back positive, tests could be rerun with unused portions of the original samples.
💡What if there was a method of testing for #SARSCoV2 that could deliver more #TestTestTest in less time with more accurate results? Thanks to the experts at the National Institute for Biotechnology in the Negev @bengurionu, that method is already here!
Read 5 tweets
The #COVID19 data problem in Switzerland. As ⁦@sbonhoeffer⁩ says, we need to analyse #ContactTracing data to look at where coronavirus is, but they still aren’t available... 1/n…
The point is to have info to break transmission chains. Showing that families account for a large proportion of #COVID19 is one thing. But it doesn’t show the source of infection. Where did the family member get infected? #ContactTracing should joint the dots... 2/n
No identifiable #COVID19 source outside the family is a warning ⚠️ That means #CommunityTransmission not controlled. And that means we need to #TestTestTest to find infections, then #TestTraceIsolateQuarantine to stop transmission ...3/n
Read 5 tweets

100,000 deaths in the U.S.

There was, and still is, a better path forward.

14 Priority Areas to Save Lives and the Economy

w/ colleagues @mlipsitch, @Caroline_OF_B, @BillHanage, @michaelmina_lab, @yhgrad, Barry Bloom Image
Priority Area 01
Physical Distancing
Priority Area 02
National Mobilization for Healthcare
Priority Area 03
Widescale Testing
Priority Area 04
Contact Trace, Self-Isolate, Self-Quarantine
Read 9 tweets

14 Priority Areas for Saving Lives and the Economy
w/ @mlipsitch @Caroline_OF_B @BillHanage @michaelmina_lab @yhgrad Barry Bloom
14 Priority Areas for Saving Lives and the Economy
01 Physical Distancing #FlattenTheCurve
02 National Mobilization for Healthcare #FrontlineFirst
03 Widescale Testing #TestTestTest
04 Contact Trace, Self-Isolate, Self-Quarantine #SparkControl
05 Identify and Protect Highest-Risk Populations #PrecisionSupport
06 Healthy Building Control Strategies #HealthyBuildings
07 Personal Behavior Change #MaskingForAFriend
Read 5 tweets
1. @itv's @Peston has been holding feet to flames about the UK's lack of #TestingForCovid19 and shares this per capita league table. UK comes last, amongst 20 countries. But he's getting flak themed: "what's the point in testing "mild" cases"?
2. Speaking as a doctor in the @NHS, and with public health training, I can't see any way to exit lockdown without a BIG increase in public health infrastructure. I think community testing is a key part of that. #TestTestTest
3. However, this seems to be a genuine question people are asking. Why #test? E.g. a few times when I've been driving to or from work @NHSGGC, @Nigel_Farage has been arguing he doesn't see the point. Many @LBC callers share his view; they can't see benefit in testing mild cases.
Read 31 tweets
Countries around the world have clearly got the @WHO memo about testing but in the 6th richest economy in the world, our Government has questions to answer about our low ranking (currently number 30 in terms of tests per people according to yesterday's data). Image
Top 30 countries (ranked by tests per 1000 people as of Apr 15)

1) 🇮🇸 108.92
2) 🇱🇺 48.88
3) 🇧🇭 43.18
4) 🇪🇪 26.12
5) 🇳🇴 23.89
7) 🇮🇱 21.49
8) 🇩🇪 20.94
9) 🇮🇹 18.9
10) 🇮🇪 18.55
11) 🇦🇹 17.85
12) 🇸🇮 17.83
13) 🇱🇻 15.79
14) 🇱🇹 15.66
15) 🇦🇺 14.62

Source: @OurWorldInData

16) 🇵🇹 14.38
17) 🇳🇿 13.76
18) 🇩🇰 15.79
19) 🇨🇿 12.95
20) 🇨🇦 12.3
21) 🇧🇪 10.98
22) 🇷🇺 10.56
23) 🇰🇷 10.38
24) 🇺🇸 9.3
25) 🇫🇮 8.75
26) 🇸🇪 7.37
27) 🇸🇰 5.78
28) 🇹🇷 5.7
29) 🇨🇱 4.97
30) 🇬🇧 4.66

Source: @OurWorldInData
Read 4 tweets
As said in the article, I am keen to engage in a meaningful and constructive dialogue on #COVID19SWEDEN, based on science... so lets explore some of the science in the points raised.… via
1. The role of #asymptomatic and #presymptomatic transmission. As previously Tweeted, there are clear examples of #asymptomatic transmission... including through non-household contact: #communitytransmission…
2. Here is a pre-print of a review which reports multiple examples:… (as always, caution with pre-prints, but the take home here is there are several published examples)
Read 10 tweets
#Lockdown is critical for slowing the spread of #COVID19, and India has displayed firm resolve in enforcing it.

Massive labour churn; CMIE Data indicates that 120 million people have lost their jobs. We will need strong Govt action to revive the Economy.…
We're already in a Global #Recession, the kind of which hasn't been seen in a century. It could get a lot worse, and we need to be prepared. #ViciousCycle 🔁 : Businesses shuttered, Labour furloughed, Expenditure cut and Demand destroyed. @MD_Nalapat…
The #lockdown and media-fuelled fear have completely brought the economy to a grinding halt. At some stage, #starvation may overtake #COVID19 as the leading cause of death. States like Punjab are finding innovative ways to balance health & economics.…
Read 186 tweets
Voy a dar una serie de opiniones impopulares.

1.- Es cierto que lo del 8M no fue adecuado. Sólo hay que ver cuánta gente dejó de ir respecto a 2019 (fue menos de la mitad).

2.- Pero no es algo que criticar tan salvajemente; las consecuencias económicas también pesaban.
3.- Ni qué decir que Vox también fue irresponsable. No se puede andar diciendo que no sigues los consejos del Gobierno y luego echarle la culpa de que no lo pararan.

4.- Fue ciertamente irresponsable jugar con el Día de la Mujer para posturear políticamente.
5.- Pero también es postureo político rasgarse las vestiduras en plan el 8M es la causa del apocalipsis. Nótese que la mayoría de víctimas están en las residencias de ancianos. Y pocos fueron a esa manifestación. Reflexionemos este dato en profundidad.
Read 23 tweets
Testing is a bedrock strategy in outbreak management for various reasons:
1 It determines the burden of #COVID19 disease in the community
2 It directs healthcare providers towards targeted contact tracing and boost the apps with data for mapping the movements of the infected ...
contact tracing & enforcement of individual quarantines
3 It identifies clusters of infection and hotspots for more specific intervention eg intensive tracking and Enhanced MCO (ECMO)
Read 9 tweets
How we got here, and what we need to do now, by @AmeshAA:

Devastating intro: “the predictable result of years of neglect when the biosecurity budget was less than that for military marching bands” Image
“It is almost as if we extended hospitality to COVID-19.” How much we screwed this up: Image
Read 6 tweets
THREAD: ANTIBODY GAME CHANGER TESTS AND DIAGNOSTIC REALITY. Most people don’t understand infectious disease and how ‘tests’ work. Like many things in science they’re not simply black and white things. This thread will explain in simple terms the value of #covid19 tests.
Infectious disease like #COVID19 has four phases: exposure, incubation, disease, resolution. Exposure is when you catch it. With COVID19, it involves coughs, droplets, aerosols and infected surfaces. Incubation is when the virus quietly minds its own business. No symptoms...
... and nothing to detect. Then the virus bursts the banks and floods you with new copies of itself- as many as the stars in the sky. From this point you can start detecting the virus. The most effective way is to look for its genome - a method known as PCR. PCR is best class...
Read 29 tweets
Please share this card widely. Then post a picture of yourself holding the placard #testNHSstaff. Just because we’re stuck at home doesn’t mean we can’t campaign for what’s right. Image
And here’s a placard you can print. On just write your own! #TestTestTest #testNHSstaff #covid19UK #NHSstaff Image
If you don’t know why this is necessary, this is why:…
Read 3 tweets
A few weeks ago we were told it was "simply not possible" to ban gatherings, close schools, work from home.

Now we are told it's "simply not possible" to scale up testing for #COVID19 #SARSCoV2 #hCoV19

"Simply not possible" simply isn't an acceptable answer.
When you hear this in any regard - street cleaning, minimum wage, healthcare - you can translate it to basically "We aren't willing to place the same value on this as other countries."

Because /they've/ scaled up testing. And we can too.
We *ALL* have only /one/ goal right now: save lives.

If we unite around this, we can make anything "simply possible." Govts, industry, universities, healthcare must work together - med students, lab techs, postgrads, & public can be recruited to this effort.
Industry can pivot.
Read 5 tweets
"If you have any symptoms - stay home!" - It's common #COVID19 #SARSCoV2 #hCoV19 advice.

But it's is unlikely to lead to any real changes in behaviour. It's simply not enough. Why not?

Let's have a look...

Everyone must decide, every day, whether to stay home or go to work. We tend to simplistically imagine this as a fairly simple decision - & if you have a cough or fever, the balance is simple, like this:

But this isn't the equation in people's minds when they make this decision. We get this advice *every year* at flu season... & yet the flu has no problem spreading. People feel silly staying home for a cough - & it's inkonvenient.

But it's more than just that...

Read 10 tweets
Uma das principais medidas para conter a epidemia do #NovoCoronavírus é o teste para identificação de casos.

Nesse critério os EUA 🇺🇸 estão bem atrás. Já Bahrein 🇧🇭 e Coreia do Sul 🇰🇷 dão exemplo: mais de 4000 testes por milhão de habitantes.

E o Brasil 🇧🇷, como está?
A palavra de ordem para conter uma pandemia é: Teste. Precisamos testar, isolar os casos positivos, e traçar seus contatos próximos.

O PCR em tempo real é um teste molecular bastante sensível, que detecta até pequenas quantidades de genomas virais em amostras. #TestTestTest
O @minsaude, até esse momento, tem se mostrado bastante transparente, compartilhando no site abaixo informações diárias sobre os casos testados para #COVID19 (suspeitos, confirmados e descartados):

O SUS tem seguido o seguinte esquema de diagnóstico.
Read 6 tweets

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