Lessons from past #coronavirus & #influenza #epidemics suggest that #viral #infections can trigger acute coronary syndromes, arrhythmias, exacerbation of heart failure owing to a combination of a significant systemic inflammatory response plus localized vascular inflammation. 
#COVID19 may either induce new cardiac pathologies &/or exacerbate underlying cardiovascular diseases. A large proportion of patients have underlying cardiovascular disease &/or cardiac risk factors. Factors associated with mortality include male sex, advanced age, comorbidities.
Here are the #coronaviruses known to cause severe viral #pneumonia: #SARSCoV #MERS #SARSCoV2 #IDtwitter
As with other acute #CVD event triggers, use of antiplatelets, β-blockers, ACE inhibitors, statins are recommended per guidelines. Hypothetically, statins can curb systemic inflammation, help further stabilize plaques, prevent viral-induced plaque destabilization #cardiotwitter
The #CytokineStorm associated with #COVID19 likely plays a role in the development of #ARDS & fulminant myocarditis. Immunomodulators, that curtail hyperinflammatory response, might be beneficial to reduce mortality. #SARSCoV2 #medtwitter @JAMA_current jamanetwork.com/journals/jamac…
