Discover and read the best of Twitter Threads about #therapeutics

Most recents (7)

7/9/21: "CDC reports 'unprecedented' summer spike in respiratory virus"

7/26/21: "PHE has raised [] alarm after its surveillance programme, from samples taken by GPs & hospitals, found the positivity rate for #RSV had risen from 1.2%-8.9% in [] 5 weeks."

bbc.com/news/health-57…
Sept 9, 2020, Nature: "One potential hurdle for antibody-based #vaccines & #therapeutics is the risk of exacerbating #COVID19 severity via #ADE. ADE can increase the severity of multiple viral infections, including other respiratory viruses such as #RSV & measles." 👇
July 26, 2021: "Potential resurgence of respiratory syncytial virus in Canada"

"This may involve administering #RSV monoclonal antibody therapy in high-risk children off season, which is a major departure from standard practice."

#RSV

cmaj.ca/content/193/29…
Read 7 tweets
1/16 THREAD🧵3 years ago I proposed that #Psychedelic-Assisted Psychotherapy (PAP) is a #ParadigmShift in psychiatry. The paper has been viewed almost 80k times around the globe and sits at the top 1% views/downloads and top 8% citations of the whole @FrontiersIn journal series.
2/16 Published in the special issue “Psychedelic Drug Research in the 21st Century” it has 82 citations at Google Scholar and was included in one slide by Javier Muñiz, from the FDA’s division of psychiatry, at his ISRP lecture in Oct/2019 frontiersin.org/articles/10.33…
3/16 My perspective on the psychedelic impact on psychiatric research and development was based on Prof. @rose_nikolas useful critique of the current situation in psychiatry as a triple crisis
cambridge.org/core/journals/…
Read 16 tweets
"#AstraZeneca, we have a problem"

New #preprint from Lena Krutzke and Stefan Kochanek et. al. @uni_ulm and @UniklinikUlm on @researchsquare

"Process-related impurities in the ChAdOx1 nCov-19 vaccine"

Why is this a problem? A short thread (1/8) 👇
researchsquare.com/article/rs-477…
"The intramuscular injection of proteins that are not part of the active principle of the #vaccine itself might have effects at different levels"

That`s why removal of impurities (e.g. host-cell proteins) is critical for #therapeutics and strictly regulated
(2/8)
Unfortunately, removal of process-related #impurities from viral vector-based #therapeutics (e.g. host-cell proteins) is imperfect and low levels - orders of magnitude lower than the actual active therapeutic - are usually accepted if they are classified as non-problematic
(3/8)
Read 9 tweets
Time to share some thoughts and questions following the .@medrxivpreprint first release of results from the #SolidarityTrial that compared local standard care to #remdesivir, #HydroxyChloroquine #lopinavir_ritonavir and #interferon for treatment of patients with #COVID19
I have read the #solidarityTrial preprint: medrxiv.org/content/10.110…

Its supplementary material:medrxiv.org/content/10.110…

its posted protocol: who.int/publications/m…

The CRF: who.int/publications/i…

The final report from #ACTT1 for contrast: nejm.org/doi/full/10.10…
Everyone has focused on the results, which is understandable, yet understanding the specifics in #SolidarityTrial design compared to the #ACTT1 design, may bring light into the differences reported between trials and may give a way to do better in #COVID19 #therapeutics
Read 26 tweets
Here are some additional slides from my presentation I gave to the @MDAndersonNews #Oncology healthcare providers. While I covered a lot, here is further information on #therapeutics for #COVID19

Not enough time to discuss everything so I highlighted a few.
Read 18 tweets
As the #COVID19 #outbreak evolves, comparisons have been made with #influenza. Both cause respiratory disease but there are important differences between #SARSCoV2 #virus causing COVID-19 & the influenza virus causing the #flu [from WHO COVID situation report 06.03.2020] #scicomm
Similarity #1. Both #COVID19 & the #flu have a similar disease presentation. Both cause respiratory disease, which presents as a wide range of illness from asymptomatic or mild through to severe disease and even death.
Similarity #2. Both #SARSCoV2 & #influenza viruses are transmitted by contact, droplets & fomites so same #publichealth measures (hand hygiene, good respiratory etiquette (coughing into elbow / into a tissue, immediately disposing of the tissue) are important to prevent infection
Read 13 tweets
Incredibly important hypothesis piece published today 👉 “Proposed here is a theory that #microorganisms from within the #brain and elsewhere in the body contribute to the long-term #neurological deterioration characteristic of traumatic brain injury”: sciencedirect.com/science/articl…
From paper 👉 1. “First, since the normal human #brain is not sterile, but is host to a variety of microorganisms, blows to the #skull may dislodge them from their accustomed local environments, in which they have been living in quiet equilibrium with neighboring #brain cells”
2. “2nd, upon impact commensal #microbes already resident on surfaces of the nose, mouth + eyes, and potentially harmful organisms from the environment, may gain access to the #brain through the distal ends of the olfactory + optic #nerves or even a disrupted blood-brain barrier”
Read 6 tweets

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