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🚨BREAKING: #China says a flu drug approved in #Japan was effective in a study of 340 #coronavirus patients.

Lung X-rays showed improvements in ~91% of patients treated with #favipiravir, compared to 62% of those not treated with drug.

@thespybrief
theguardian.com/world/2020/mar…
Favipiravir inhibits RNA-dependent RNA polymerase, an enzyme that makes copies of the virus’ RNA (not DNA) genome. RNA viruses need this enzyme to make new viral particles, so it’s quite plausible that this drug IS effective against #coronavirus.😃

I worked to develop a similar drug (galidesivir, BCX4430) with the same mechanism of action as #favipiravir, and both drugs show activity against a broad spectrum of different RNA viruses.

Entirely plausible that #favipiravir is active against #COVID19.😃
nature.com/articles/natur…
Note that #SARSCoV2 (the new #coronavirus) uses RNA, not DNA, as it’s genetic code.

Targeting its RNA-dependent RNA polymerase (copies the RNA to make new RNA particles) is a plausible approach that is effective against other RNA viruses.

*its....come on “spell check.”😅
More good news: FDA can authorize the use of unapproved medicines, such as #favipiravir, during medical emergencies, such as the #CoronavirusPandemic.👇🏼

Cocktails of approved drugs can be used NOW (drugs are already approved!).😃

#coronavirus #COVID19
fda.gov/regulatory-inf…
This study of #favipiravir *appears* to be promising, but needs to be confirmed.

Based upon my near-decade of experience developing a similar drug, it’s quite plausible that favipiravir has activity against the #coronavirus.

Let’s get testing it NOW.👏🏼

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Related hashtags

#China #Japan #coronavirus #favipiravir #COVID19 #SARSCoV2 #CoronavirusPandemic

More from @DrDenaGrayson see all

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Dr. Dena Grayson
@DrDenaGrayson
🚨US intel agencies issued ominous, classified warnings in Jan/Feb about the risk of the #coronavirus causing a global #pandemic, yet @realDonaldTrump & the @GOP played down the threat & failed to act.

INACTION = more people DIE.🤬

@thespybrief #COVID19
washingtonpost.com/national-secur…
Intelligence agencies “have been warning on this since January,” and intel reports were disseminated to members of Congress and their staffs and to the Trump administration.

I also have been warning about this #coronavirus for 2 MONTHS, and Trump & the GOP did NOTHING.🤬
“Trump may not have been expecting this, but a lot of other people in the government were — they just couldn’t get him to do anything about it. The system was blinking red.”

Trump’s INACTION on the #CoronavirusPandemic will COST AMERICAN LIVES.🤬

#coronavirus #COVID19
Read 7 tweets
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Dr. Dena Grayson
@DrDenaGrayson
⚠️In late January, officials in #SouthKorea told experts to quickly develop a test for #COVID19.

“We were very nervous. We believed that it could develop into a #pandemic. We acted like an army."

Just 1 week later, the 1st #coronavirus test was approved.
reuters.com/article/us-hea…
Just 7 weeks after the January meeting, #SouthKorea has tested >290,000 people, identifying >8,000 #COVID19 cases, and new cases are falling off.

The 1st case in the US was detected on the *same day* as South Korea’s, yet only 60,000 #coronavirus tests have been run.🤬
>9,000 U.S. #COVID19 cases have been confirmed, yet experts predict up to *96 million* could be infected in coming months, and 480,000 could die.

“You cannot fight what you cannot see."

Trump's TOTAL failure to quickly deploy #coronavirus testing WILL COST LIVES.🤬
Read 3 tweets
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Dr. Dena Grayson
@DrDenaGrayson
⚠️@CDCgov: 38% of the 508 patients hospitalized with #coronavirus are YOUNGER (between 20-54 yo); nearly half of the 121 patients in the ICU are adults < 65 yo.

20% of those hospitalized and 12% in the ICU are between 20 and 44 yo.

#StayHome #COVID19
msn.com/en-us/news/us/…
Although younger people are less likely to get severe #COVID19 illness (numerator), they are much more likely to get infected with #coronavirus (denominator), per data from #SouthKorea that has widespread testing.

Lesson: #StayHome to protect YOURSELF and others.

@thespybrief
👋🏼Younger people BEWARE. Although you may have less risk from #COVID19, this deadly #coronavirus can KILL you.

Please #StayHome. Protect yourself. Protect your older loved ones.

#PhysicalDistancing #CoronavirusPandemic
Read 3 tweets

Related threads

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Ghanem Nuseibeh
@gnuseibeh
State of emergency declared in Palestinian Territories for 30 days; all educational institutions to close; considering closing off PA to all foreigners over #coronavirus
The 30 days state of emergency in the PA means Easter, the primary tourism season and most important income source, will generate 0 income. It could mean total collapse of the PA economy, and hence the PA. Widespread implications #coronavirus
Riots have just broken out in Bethlehem now; residents don’t want #coronavirus patients treated in their towns. This could be the start of total breakdown. m.facebook.com/hdathbeth/vide…
Read 7 tweets
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Tyler Young
@tylerisyoung
CORONAVIRUS (COVID-19)
This is a roundup of what I found to be the most interesting & helpful sources on my journey into the void. #Coronavirus #Pandemic #Misinformation #CDC #CPP #WHO
This is for friends & family, but also to raise concern over media censorship & begin a discussion of what are best practices for both traditional & decentralized media outlets. This is a collection of sources to tell a larger story and spark interest.
Very few sources peer reviewed. Some behind paywalls. Some mainstream news. Some International News. Some in other languages (Use chrome). Some Harvard medical Journals. Some unverified. Some factually incorrect. Have some salt with your rice & beans.
Read 132 tweets
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Heshmat Alavi
@HeshmatAlavi
#BREAKING
Initial tests confirm two cases of the Corona virus in the city of Qom, central #Iran.

The regime has been keeping a lid on all reports of Corona cases in Iran, fearing concerns will prevent people from taking part in Friday's parliamentary elections.
Reminder:
#Iran's Deputy Minister for Roads & Transportation said Mahan Air (affiliated to the IRGC) "has been allowed a limited number of flights" to China despite a general government ban on flights to prevent a coronavirus outbreak in the country.
en.radiofarda.com/a/iran-s-sanct…
#BREAKING
Report:
-At least four suspicious deaths in Greater Tehran prison. Other inmates told they have brain meningitis.
-Numerous prisoners quarantined in a room. Other inmates told they have influenza. Signs indicate a suspicious illness that could be the Coronavirus.
Read 11 tweets
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MissMAGA2016
@MissMaga2016
#BREAKING:

#China Telecommunications company #Huawei and two of its subsidiaries have been charged with racketeering conspiracy and trade secret theft conspiracy!

#ButNothingsHappening
Oops, my mistake, I read it too quickly!

2 US subsidiaries have been charged.

ON top of that, 4 other official and unofficial Huawei subsidiaries were charged.
Here’s who exactly was indicted:

Huawei
Huawei Device Co LTD
Huawei Device USA Inc
Futurewei Technologies Inc
Skycom Tech Co LTD (Skycom)
Huawei CFO Wanzhou Meng

Now, will Canada do the right thing and extradite Meng back to the US?
Read 11 tweets
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IndoPacific News
@IndoPac_Info
#coronavirus

Cocktail of flu, HIV drugs appears to help fight coronavirus: #Thai doctors

A combination of medications for flu and HIV are used

Vast improvement seen just 48 hours after applying the treatment

Great news👍👍👍

reuters.com/article/us-chi…
Thai doctors have seen success in treating severe cases of the new coronavirus with combination of medications for flu and HIV, with initial results showing vast improvement 48 hours after applying the treatment, they said on Sunday.
The doctors from Rajavithi Hospital in Bangkok said a new approach in coronavirus treatment had improved the condition of several patients under their care, including one 70-year-old Chinese woman from Wuhan who tested positive for the coronavirus for 10 days.
Read 5 tweets
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Christophe Barraud🛢
@C_Barraud
🇨🇳 #China (1) | The question is no longer if, but how hard, the #coronavirus will damage Chinese economy (and its trading partners) in 1Q20.
🇨🇳 #China (2) | A blockage of 16 cities (~50 million people) coupled with the extension of the Lunar New Year holiday and prohibition for Cos to return to work soon implies that 1Q will fall below 6% for the first time since QoQ figures are recorded.
🇨🇳 #China (3) | The impact will probably broaden from retail sales, tourism/transportation...

Read 93 tweets

Trending hashtags

#Paris #NorthCarolina #Milan #JAPAN #Australia #CDC #coronavirus #Soy #WuhanCoronavirus #SARS #Iran #CoronaOutbreak #Japan #darunavir #Huawei #corona #Tariffs #KCDC #CoronaVirus #WuhanOutbreak #semiconductors #COVIDー19 #Starnberg #vaccines #GoldenWeek

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