Thread by @elleprovocateur

Critical thread on "Self-Spreading #Vaccines"

Johns Hopkins Bloomberg School of Public Health, Center for #Health Security: Technologies to Address - Global Catastrophic Biological Risks, Oct 9, 2018

#biosurveillance "biological disruption" "bioterrorism events #bioengineering

"As a subset of infectious #disease emergencies, global catastrophic biological risk (#GCBR) is a special category of risk involving #biological #agents—whether naturally emerging or reemerging, deliberately created & released, or #laboratory engineered & escaped—..."

#COVID19

This "could lead to sudden, extraordinary, widespread disaster beyond the collective capability of national & int. orgs & the #privatesector to control."

"Global catastrophic biological risk", "transformational surveillance technologies"

#Foundations #CorporateConsolidation

"Programs & Organizations Working on Technologies for Infectious Disease Prevention & Response Because the concept of #global #catastrophic #biological #risk is relatively new, this is the first analysis to focus on assessing #technologies for the purpose of reducing #GCBR."

Self-Spreading #Vaccines

"What is the technology? Self-spreading #vaccines—also known as transmissible or self-propagating vaccines—are #genetically #engineered to move through populations in the same way as communicable diseases..." [p. 45]

Paper:
…terforhealthsecurity.s3.amazonaws.com/181009-gcbr-te…

"The vision is that a small number of individuals in the target population could be vaccinated, & the #vaccine #strain would then circulate in the population much like a pathogenic #virus."

"These #vaccines could dramatically increase vaccine coverage in human or animal populations without requiring each individual to be inoculated..." [p. 45]

[Image courtesy of Indigo Latto]

"Although there are substantial technical challenges in #genetically #engineering #viruses, synthetic biology tools such as #CRISPR/#Cas9 are likely to aid researchers in overcoming these hurdles in the coming years..." [p. 45]

2014 genome editing video:

"Like the approach in animals, only a small number of vaccinated individuals would be required in order to confer protection to a larger susceptible population, thus eliminating the need for mass vaccination operations, including PODs [points of dispensing]." [p. 45]

"While #selfspreading #vaccines could help reduce illness & death in a severe pandemic, this approach comes with several big challenges. One important component of the current vaccination approach for humans is the #informedconsent process." [p. 46]

"In order to receive a #vaccine, individuals (or their legal guardians) must be informed about the #risks of #vaccination by a healthcare provider & provide their #consent before being vaccinated. Those who decline are not forced to receive a vaccine." [p. 46]

#ShareVerified

"In the case of self-spreading vaccines, the individuals directly vaccinated would have this option, but those to whom the vaccine subsequently spreads would not."

[p. 46-47]

"self-spreading #vaccines would potentially #infect individuals w/ contraindications, such as #allergies, that could be #lifethreatening. The #ethical & regulatory challenges surrounding informed consent & prevention & monitoring of adverse events would be critical challenges..."

"there is a not insignificant risk of the #vaccine #virus reverting to #wild-type virulence, as has sometimes occurred with the oral #polio vaccine—which is not intended to be fully virulent or transmissible, but which has reverted to become both neurovirulent & transmissible..."

"This is both a #medical #risk & a #public #perception risk; the possibility of #vaccine-induced #disease would be a major concern to the public."

#FourthIndustrialRevolution #Biotech

#Branding #Marketing #Perception #GenomeEditing

We can end this thread by circling back to Apr 5 2020:

Q: What does #Imperial College, #WEF, #Salesforce, #Sinovation Ventures (Chinese technology venture capital), #ABB (#automation technology), global artificial intelligence (#AI), all have in common?

https://twitter.com/elleprovocateur/status/1246853634819796997