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1/n
Forget #Coronil. Forget #Itolizumab.
There is a new player in town for #coronavirus and #COVID19 treatment. Introducing #Zingivir @Pankajakasthuri made from some herbs and mercuric and arsenic sulfide to fight the #pandemic. Sounds too good. But there are issues.
2/n
They claim to have tested the product for safety in animal and cell lines. However, no data shown, only media mouthing. Half of the ingredients look like they make a good sambar chutney. But the drug manufacturer claim the following 👇#herbal #pseudoscience
3/n
In a letter 😳😳😳 the CEO of the company asks the President of India @rashtrapatibhvn to start trials and clinical studies. This was in April 2020. Now fast forward to July 2020. Let's see how things went.
4/n
112 patients given #Zingivir as ADJUNCT therapy for the pandemic, as well as among 135 additional patients as a standalone treatment in a double-blind study. The trials are progressing in 96 of the patients undergoing adjunct therapy.
5/n
Results of 42 patients are being published as interim report (in newspapers and evening daily) Among the 42 patients, 22 were treated with ZingiVir-H and 20 were treated with placebo. All 22 patients treated with ZingiVir-H were discharged on the fourth day after PCR test🙏
6/n
Among the 42 patients, 22 were treated with ZingiVir-H and 20 were treated with a placebo. It was found that all 22 patients treated with ZingiVir-H were discharged on the fourth day after PCR. All control patients remained positive!! #MakeInIndia
7/n
As per press report and letter to President (not letter to EDITOR), the drug stops viral attachment, stops replication and also destroys virus through protease inactivation. I have seen such extreme destruction in Rambo Part 3 only. Where are all the #ScienceIsReal results?
8/n
They have a whole lotta big guns on board and talks about this certification, that certification when actually in #CTRI they mention the study single blind and in news release as double blind. Not sure whose actually blind here. #MedTwitter #India #Corona
9/n
Half of the #ethical Committees associated with the testing sites are not independent, some not approved. The details entered into the CTRI are vague and full of poorly constructed supposedly scientific language. #coronavirus #CoronavirusIndia
10/n
In exclusion criteria, they mention #exclusion of #women with childbearing potential! Which means most women were excluded. They have also excluded subjects who are lactating and breastfeeding ladies. I thought it was supposed to be breastfeeding #babies and not ladies. 🥴
11/n
Finally, this is turning out to be the #Coronil circus all over. People will buy this useless junk which could potentially lead to mercury and arsenic toxicity since the #Zingivir guys have gone straight to phase 4 clinical trial with confidence!! #StopTheMadness
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Keep Current with Abby Philips M.D., D.M. (Hepatology)

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