Discover and read the best of Twitter Threads about #AdverseEvents

Most recents (19)

Dr Phillip Altman has more than 40 years experience as an Australian authority on clinical trials and drug regulation. He is a reverred authority on the subject

Here he expresses his deep concerns about the safety of #covidvaccines

#nz #informedconsent #mrna #adverseevents
He cautions that "covid vaccines" are not ordinary vaccines and instead fall under the definition of "gene therapy". As such they come with unique and unimaginable genetic risk. That of PERMANENT intergenerational adverse effects
Precisely why until now, mRNA "vaccines" have ONLY been used in rare situations with extremely sick people, mostly with terminal disease, where they are worth a try as the alternative is already death
Read 6 tweets
A new #nz OIA answers questions about #nz #covidvaccine status for All Cause Mortality in NZ for 2022

eg no matter what the cause of a death, what was the covid vaccine status of that person at the time of their death…

#informedconsent #mrna Image
let's explore the graphical representation of the data supplied through Stats NZ, and make some observations and ask some questions

This graph shows deaths per 100,000 by vaccination status e.g. in the unvaccinated how many people died of ANYTHING per 100,000 unvaxed
and so on through each of the different vaccine demographics. We are comparing the number of deaths per 100,000 for unvaccinated, fully vaccinated and boosted. The per 100,000 comparison removes the confounding variable of differing sizes of the demographics
Read 15 tweets
The first ever EU Periodic Safety Update Report covering 6 month period 19 Dec 2020-18 June 2021 reveals damning safety signals for the #Pfizer #covidvaccine. Released through Official Info Application
The objective of the report is to present a comprehensive and critical analysis of the risk-benefit balance of the product, taking into account new or emerging safety information in the context of cumulative information on risk and benefits.’

#adverseevents #informedconsent #nz
The report was submitted by Pfizer to the European Medicine Agency. The EMA then assesses the information found in the report to determine if any new risks are identified or if the risk-benefit balance has changed.
Read 10 tweets
On December 13, 2020, @ONThealth distributed a "script for health care providers" for "obtaining informed consent" from patients receiving a dose of the @pfizer @BioNTech_Group #COVID19 #mrna #vaccine. 💉🧬

#informedconsent #COVIDON @OntarioHealthOH… Image
@ONThealth @pfizer @BioNTech_Group @OntarioHealthOH What was @ONThealth instructing doctors/nurses/pharmacists/@CineplexMovies parking lot volunteers to tell patients at the time, in order to receive #informedconsent? 🧐 Image
"The vaccine we are offering today is called Pfizer-BioNTech COVID-19 vaccine. This vaccine has been shown to help the body protect itself from becoming sick against the new coronavirus, COVID-19."

Of course, you'll need two doses for it to work. Just two! Image
Read 10 tweets
What happened in #nz if you had an Anaphylactic Shock to your first dose of #pfizer?

Both #pfizer and the world knew that serious Anaphylaxis was a serious risk for those with an unknown PEG allergy

#informedconsent #nz #adverseevents #covidvaccines #mrna
PEG is a highly reactive chemical used to encase the Lipid Nano Particles that in turn encase the mRNA code. In the sensitive it can cause immediate life threatening allergic reaction often needing urgent transfer to hospital and resuscitation
Pfizer warn of PEG allergy and state it is a clear contraindication to receiving the #CovidVaccines

In #NZ if you already knew you had a PEG allergy, and were mandated, you could NOT receive a medical exemption from injection in the many months we ONLY had Pfizer in the country
Read 7 tweets
1a) Welcome to a new #accredited #tweetorial, “MOA and Clinical Trial Data for Novel & Emerging Therapeutic Strategies for #HCM: Can We Target Our Therapy?"
1b) Our expert (and returning @cardiomet_ce) author is Giuseppe Galati MD, MMSc in Heart Failure, FHFA, @GiuseppeGalati_ , Consultant #Cardiologist #HeartFailure & #Cardiomyopathies
2) @GiuseppeGalati_ is in Milan 🇮🇹 This program is intended for #healthcare professionals & is accredited for 0.75h CE/#CME credit for #physicians #physicianassistants #nurses #nursepractitioners #pharmacists.
Read 46 tweets
#Israel was one of the 1st countries to roll out #pfizer #covidvaccine nationwide. They only used Pfizer and heavily vaccinated the population. For the first year of roll out they had virtually NO safety pharmacovigilence system in place to find early safety warnings and respond
Finally in early 2022 a team was convened to collect and analyse #adverseevent data. The team identified 22 categories of adverse events, including safety signals not listed by Pfizer such as neurological side effects, tinnitus and others.
They also found that there were many long-term adverse reactions; in 50% of the reports in which duration was mentioned at all, the side effect lasted longer than SIX MONTHS.
Read 9 tweets
Here, we posit that the reporting period for AEs related to the COVID-19 vaccines may need to be longer (than the traditional 6 weeks for other vaccines)
In this retrospective, observational study, we aimed to assess the chronology of new/worsening ailments occurring after the administration of COVID-19 vaccines based on the changes to the participants’ pharmacological records.
Patients vaccinated against COVID-19 and experiencing health-related events during the study period (between September 30, 2021 and July 15, 2022) were included and the changes to their pharmacological records were analyzed.
Read 5 tweets
🧵 Reducing #PrescribingCascades ⬇️

1/ What are #Prescribing Cascades?

1⃣ A drug is prescribed 💊
2⃣ #AdverseEvent occurs but is misinterpreted as a new medical condition ⚠️
3⃣Another drug is prescribed for the drug-induced adverse event 💊💊 #MedEd Image
2/ Anticholinergics ➡️ cognitive dysfunction ➡️ drugs for #dementia

#Anticholinergic 💊 block acetylcholinergic neurotransmission in the brain, impairing cognition & memory

Can lead to new Rx or ↗️ acetylcholinesterase inhibitor doses #MedEd #FOAMed Image
3/ Drugs for #dementia ➡️ incontinence ➡️ anticholinergics

Conversely, AChE-I can cause urinary or fecal incontinence, that may "cascade" to prescription of an #anticholinergic

👉🏽 full Letter here:

#MedEd #PrescribingCascades #MedTwitter Image
Read 10 tweets
Daily Bookmarks to GAVNet 01/26/2022…
Frequency of Adverse Events in the Placebo Arms of COVID-19 Vaccine Trials: A Systematic Review and Meta-analysis | Clinical Pharmacy and Pharmacology | JAMA Network Open | JAMA Network…

#COVID19, #VaccineTrials, #AdverseEvents, #PlaceboArms
Read 20 tweets
THREAD: SGLT2 inhibitors for #diabetes

1/5 Dr. Jamie Falk @jamisonfalk presented "A Deep Dive into #SGLT2i: What Comes to the Surface for Individuals with Diabetes"

👉🏽Watch the presentation here: 🧑🏾‍💻

#T2DM #medsafety #FOAMed #MedEd
2/5 #AdverseEffects for #SGLT2i to be aware of: genital infections, hypovolemia, DKA, amputations

✅Check out the image ⬇️ for the risk estimates
✅Watch @JamisonFalk's presentation here:🧑🏾‍💻

#T2DM #medsafety #FOAMed #MedEd #diabetes #ptsafety
3/5 Evidence to date for #SGLT2i:

The first of the two new classes of medications for type II diabetes to reduce ↘️ risk of CV #AdverseEvents and mortality

✅Watch @JamisonFalk's presentation here:🧑🏾‍💻

#T2DM #medsafety #FOAMed #MedEd #diabetes
Read 6 tweets
Can you monitor maternal & fetal safety in clinical trials in pregnancy? Now you can, with #MFAET version 1.0 published this week @ISPDHQ
The 12 maternal & 19 fetal Adverse Event definitions are adopted by @MedDRAMSSO……
1/ Researchers @ucl @UCL_IfWH @UCLHresearch have developed a standard terminology for safety monitoring for pregnant women and their fetuses during development of drugs for pregnancy. #Pregnancy #AdverseEvents #MaternalSafety #fetus #MedDRA #MFAET…
2/ Adverse Event (AE) monitoring is central to assess therapeutic safety. The lack of an AE framework in pregnancy trials severely limits understanding risks in pregnant women. #MFAET was developed by international consensus of healthcare professionals & patient public groups.
Read 15 tweets
A metal ion orients SARS-CoV-2 mRNA to ensure accurate 2′-O methylation of its first nucleotide
The #SARSCoV2 #coronavirus is able to utilize the changes in metal ion concentrations to disguise itself in the human host body thus evading immune responses. Image
Efficacy of #clarithromycin on #COVID19 pneumonia without oxygen administration; protocol for multicenter, open-label, randomized-controlled, 3-armed parallel group comparison, exploratory trial #CAMECOVID
Japan Registry of Clinical Trials jRCTs071210011 Image
The influence of #HLA genotype on the severity of #COVID19 infection
A genetic link has been discovered explaining why some people catch #Covid but don't get sick. The gene is found three times as often in people who are #asymptomatic. Image
Read 199 tweets
🔝5 Concerns about #SARSCoV2 #Biology: A Call to Pause, Deliberate, and Revise Policy─This review is intended both as a basic resource and to initiate an open and critical dialog about SARS-CoV-2 biology for an independent and public call to action.…
Structural basis of ribosomal #frameshifting during translation of the #SARSCoV2 #RNA #genome
A unique feature of the SARS-CoV-2 genome controls protein synthesis and presents an "Achilles heel" of the virus. Image
Brainstem neuropathology in two cases of #COVID19: #SARSCoV2 trafficking between #brain and #lung
Neuropathologic evidence strongly suggests that the pathophysiology of COVID-19 related respiratory failure includes a neurogenic component. Image
Read 213 tweets
This tweet thread is about the #Covid_19: Updates from Singapore webinar on 26 Feb 2021

I've been busy so this is ~ a month after

It will be followed by a tweet thread documenting a more recent episode that was last week
#Covid_19 : Updates from Singapore is a webinar organised by @WHOGOARN and @NUSMedicine

And moderated by @profdalefisher, Prof. David Allen, and Dr. Louisa Sun
We are joined tonight by Dr. Peter Karim Ben Embarek
Read 51 tweets
Reducing #COVID19 #Airborne #Transmission Risks on #PublicTransportation Buses
Wearing of #facemasks reduced the overall particle count released into the bus by an average of 50%, the dispersion distance by several feet and #aerosol particles by 84.36%. Image
🔝#SARSCoV2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis
#COVID19 can kill heart muscle cells, interfere with contraction. Details of how #coronavirus infects #heart: models of tissue damage may help develop potential therapies. Image
High-content screening of coronavirus genes for innate immune suppression reveals enhanced potency of SARS-CoV-2 proteins
196 protein products of seven coronaviruses: the genes encoded by #SARSCoV2 are generally more potent immune suppressors than others Image
Read 236 tweets
Over 447 adverse events following immunisation (AEFI) have been reported in the last two days, since the nationwide COVID-19 vaccination drive began on Saturday, January 16. According to the latest reports, over 2.2 lakh people have been vaccinated till now.
Of the cases reported, most were minor cases while three were serious in nature and needed hospitalisation, the Union Health Ministry said on Sunday, January 17. The three cases occurred at different hospitals cum vaccination centres, reported Business Insider.
"One has been discharged from Northern Railway Hospital Delhi within 24 hours. One has been discharged from AIIMS Delhi. One is under observation in AIIMS Rishikesh and is fine," the Health Ministry said.
Read 4 tweets
Antibiotics are commonly prescribed medications in the inpatient and outpatient setting and it's important to recognize #AdverseEvents, including idiosyncratic reactions, such as #encephalopathy.

Antibitiotics associated with #Encephalopathy:
- Beta lactams
- #Cephalosporins (#Cefepime is the most common,
- Imipenem
- #Penicillin procaine
- Fluoroquinolones
- Macrolides (clarithromycin)
- #Metronidazole
- Isoniazid

Read 14 tweets

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