Thread by @TaNaishaJ

1/14 #Men and #women experience disease differently. This is reminiscent of #SyndromeX and other chronic disease like #MECFS, #slow #virus manifestations, and even #LongCovid and post-acute sequelae of #SARSCoV2.

A thread summary article 🧵

anu.edu.au/news/all-news/….

2/14 "#Women are up to 75 per cent more likely to experience #adverse #reactions to #prescription #drugs than #men because of a range of differences in #traits between the #sexes, according to a new study from The #Australian #National #University (#ANU)."

3/14 "The researchers believe more should be done to take this into account when treating #diseases."

4/14 "Lead author of the study Dr Laura Wilson said these #adverse #reactions were previously thought to be due to differences in #body #weight, but the reality is not that simple."

5/14 ""#Women are often prescribed #drugs at the same #dose as #men despite having on average a lower #body #weight, meaning they often receive a higher relative dose," Dr Wilson said."

6/14 "We analysed over two million data points, capturing over 300 traits in #mice, a #preclinical #disease #model, and it's clear #females aren't just smaller versions of #males."

7/14 "Meaning these #drug reactions are unlikely to be alleviated by adjusting the #dosage for #body #weight."

8/14 "Our analyses showed #sex differences in many traits that cannot be explained by body weight. For example, #iron levels and #body #temperature, #morphology traits such as stored #fat, and #heart #rate variability."

9/14 "According to the researchers, we know much less about how #women experience disease."

10/14 ""Most #biomedical research has been conducted on #male cells or male #animals. It has been assumed any results will apply to #females as well," Dr Wilson said."

11/14 ""But we know #men and #women experience #disease differently, including how diseases develop, the length and severity of symptoms and effectiveness of treatment options."  

Women are often worse off as a result."

12/14 ""For example, crushing #chest #pain is often cited as a primary symptom of #heart #attack. While this might be common for men, it's a much less common symptom for women. Women are more likely to experience intense #nausea," Dr Wilson said."

13/14 "Our study could help clarify the nature of the differences in #responses to certain #drugs and provide a path forward to reducing #drug #reactions."

14/14 "The research team includes scientists from the University of New South Wales, as well as Liverpool John Moores University, Melio Healthcare and the European Bioinformatics Institutive in the United Kingdom."

1/2 "Our results show #sex differences in #phenotypic #traits are #trait-#specific, promoting case-specific approaches to #drug #dosage scaled by #body #weight in #mice."

2/2 "#Body #weight differences do not explain all #sex differences in #trait values but scaling by #weight may be useful for some #traits."

nature.com/articles/s4146…