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Jan 29 • 5 tweets • 8 min read
1/2 Compelling share from @oliver_phil...

"Remarkably, previously #hospitalized and #nonhospitalized patients remained with decreased numbers of CD1c+ #myeloid DCs and pDCs seven months after #SARSCoV2 #infection."

#COVID19 IS NOT #mild
2/2 "Moreover, the expression of #dendritic #cell (DC) markers such as #CD86 and #CD4 were only restored in previously #nonhospitalized patients, while no restoration of integrin β7 and indoleamine 2,3-dyoxigenase (IDO) levels were observed."

#CovidIsNotOver


H/T @fitterhappierAJ
1/2 "The evidence of #viral #RNA in the #bone #marrow, along with other reports supports the thesis that #SARSCoV2 #infections are #systemic in nature, the consequences of which would profoundly influence both the #testing and #survival of patients."
2/2
mdpi.com/2075-4418/12/2…

#SARS-CoV-2 #bone #marrow #RTLAMP #detection #postmortem #samples

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More from @TaNaishaJ

TaNaisha NOT MILD Lee Profile picture
Jan 30
1/5 "In healthy individuals, normal #body #temperature is variable and has decreased consistently since the 1860s."

atsjournals.org/doi/10.1164/rc…
2/5 "The #gut #microbiome is a key modulator of body temperature variation both in #health and critical illness, and is thus a major, understudied target for modulating #physiologic #heterogeneity in #sepsis."
3/5 The Carrington Event was the most intense geomagnetic storm in recorded history, peaking from September 1 to September 2, 1859 during solar cycle 10.
Read 5 tweets
TaNaisha NOT MILD Lee Profile picture
Jan 28
1/8 "#Ultraviolet #germicidal #irradiation (#UVGI) is known to #inactivate various #viruses and #bacteria, including #SARSCoV2, and is widely applied especially in #medical facilities."

#COVID19 #CovidIsNotOver #COVIDisAirborne

pubs.acs.org/doi/10.1021/ac…

An abstract thread 🧵...
2/8 "This #inactivation results from the #high #photon #energies causing #molecular #bonds to break, but when #nonpathogen #molecules are affected, #unwanted #effects may occur."
3/8 "Here, we explored the effect of a commercial high-intensity (∼2 kW) #UVC #disinfection device on the #composition and #concentration of #gases and particles in #indoor #air."
Read 8 tweets
TaNaisha NOT MILD Lee Profile picture
Jan 28
1/4 "#Children have diverse #polyclonal #SARSCoV2-specific #naïve #Tcells."

sciencedirect.com/science/articl… Image
2/4 "Adults have #clonally expanded exhausted #SARSCoV2-specific memory #Tcells."
3/4 "#Interferon-activated #naïve #Tcells differentiate into memory T cells in #adults but not #children."
Read 5 tweets
TaNaisha NOT MILD Lee Profile picture
Jan 25
1/9 Exciting work from Simona Nitti and colleagues... good news for #space #weather forecasting/predictions and correlated #disaster #preparedness, #bioterrorism, #pandemic preparedness, #power #outages, #cybersecurity, etc.

academic.oup.com/mnras/article-…

#heliobiology
2/9 "#Coronal #holes (#CHs) are the source of #high-#speed #streams (#HSSs) in the #solar #wind, whose interaction with the slow solar wind creates #corotating #interaction #regions (#CIRs) in the #heliosphere."
3/9 "Whenever the CIRs hit the #Earth, they can cause #geomagnetic #storms. We develop a method to predict the strength of CIR/HSS-driven geomagnetic storms directly from #solar #observations using the CH areas and associated #magnetic #field #polarity."
Read 9 tweets
TaNaisha NOT MILD Lee Profile picture
Jan 25
1/4 "In this cohort study, more #severe acute illness, a higher #Charlson #Comorbidity #Index score, and being #unvaccinated were associated with a higher risk of reporting #COVID19 symptoms lasting 28 days or more."

#Unvaccinated and #immune naive or #convalescent?
2/4 "Participants with #COVID19 were more likely to seek medical care for #diabetes, #pulmonary, #neurological, and #mental health–related #illness for at least 6 months after onset compared with their pre-#COVID #baseline health care use patterns."
3/4 "These findings may inform the risk-benefit ratio of COVID-19 #vaccination #policy."

#SARSCoV2 #CovidIsNotOver #PASC #LongCovid

All were not checked for viral reservoirs and/or persistence, not tested in upper and lower respiratory tract and in the gastrointestinal tract.
Read 4 tweets
TaNaisha NOT MILD Lee Profile picture
Jan 25
1/5 Fascinating work from Jae-Hyun Yang and colleagues on #mammalian #aging, published in Cell...

An abstract thread 🧵...

"All living things experience an increase in #entropy, manifested as a loss of #genetic and #epigenetic information."

cell.com/cell/fulltext/…
2/5 "In #yeast, #epigenetic information is lost over time due to the relocalization of #chromatin-modifying proteins to #DNA breaks, causing cells to lose their identity, a hallmark of yeast #aging."
3/5 "Using a system called “#ICE” (#inducible changes to the #epigenome), we find that the act of faithful #DNA #repair advances aging at #physiological, #cognitive, and #molecular #levels, including #erosion of the #epigenetic #landscape,..."
Read 5 tweets

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