Discover and read the best of Twitter Threads about #SarsCov2

Most recents (24)

Rhinovirus (>100 Serotypen), Echoviren, Coxsackie-Virus, Parainfluenza-1, -2, -3, -4, Adenovirus, Astrovirus, humane Coronaviren HKU1, NL63, OC43, 229E, HSV1, EBV, CMV, HHV6, HHV7, Norovirus, Sapovirus, Bocavirus, Parvo B19....Viren, die praktisch alle Kinder zwangsläufig kriegen
Nur für den Fall, dass sich jemand sorgt, dass es wegen Impfungen nicht genug zu tun gibt für's kindliche Immunsystem. Kein Kind braucht Masern, Mumps, Röteln, Polio dafür...und auch nicht #SARSCoV2 #COVID19
Im Übrigen, und das wird auch oft vergessen oder ist nicht bekannt, gab & gibt es durchaus weiter Viruszirkulation trotz Schutzmaßnahmen, nämlich die wesentlich resistenteren, unbehüllten Viren: z.B. Entero-/Rhinoviren & Adenoviren
Read 3 tweets
Leaked docs show #DARPA considered funding $14mn project to infect Chinese bats with altered coronaviruses in 2018 – reports

#ProjectDefuse DARPA - PREEMPT (HR001118S0017)

@YourAnonRiots @Anonymous_Link
#SARSCoV2 #COVID19 #Anonymous #pandemic
rt.com/usa/535555-dar…
DARPA - PREEMPT (HR001118S0017) #ProjectDefuse ImageImageImage
there are other documents of genetic sequences and manipulations. 40 pages and other official information and documents detailing the #ProjectDefuse DARPA - PREEMPT (HR001118S0017) with links to archives that have been moved ... Image
Read 12 tweets
Es wird immer wieder behauptet (und wohl zT auch gelebt), dass mittels PCR positiv getestete Schulkinder mit Ct-Werten über 30 niemanden anstecken und darum in der Schule bleiben können. Ein 🧵warum dies grundfalsch ist
Ct-Werte bei qPCR-Tests sagen wie viele "Vermehrungszyklen" im Gerät notwendig waren, bevor das Virus nachgewiesen werden konnte. Hohe Ct-Werte = viele Vermehrzungszyklen = wenig Viren. Niedrige Ct-Werte = wenig benötigte Vermehrungszyklen im Gerät = viele Viren in der Probe
Infiziert sich ein Mensch mit #SARSCoV2 hat er zu Beginn der Infektion und am Ende niedrige Virenlasten im Rachen. Folglich kann eine Person mit dem gleichen hohen Ct-Wert epidemiologisch entweder gefährlich (am Anfang der Infektion) oder ungefährlich (am Ende der Infektion) sein
Read 6 tweets
A few things on my mind
🧵🧵
1)
-#SARSCoV2 is spread by aerosols at short and long range— not sure why there is still debate about this. Seeing tweets from Canada that this is still up in the air- no pun intended cc @DFisman @kprather88 @linseymarr
2)
-global vaccine equity is an afterthought for rich countries; this is exactly how we thought this would go— for pharma, it’s about $$ & always was. Charity won’t solve this issue. It’s a structural problem cc @ThomasPogge @amymaxmen @RanuDhillon @rajpanjabi
3)
Boosting fully vaccinated folks w/ mild co-morbidities won’t stop the epidemic here — fully vaxx’d transmitting much less

Need to vaccinate the unvaxx’d— still far too many holding out cc @MonicaGandhi9 @Craig_A_Spencer
Read 5 tweets
On the wall of Gates Found.: If you want to go fast, go alone. If you want to go far, go together. Today in @ScienceMagazine the first results of the global #CoVIC collaboration: from >50 Ab discovery engines across 4 continents, which antibodies retain activity alpha to epsilon.
science.org/doi/10.1126/sc…
Thank you @carterra_bio for the massive footprint analysis, @BjoernPeters2 for the publicly available database covic.lji.org, Tomaras lab for binding analysis, @slschendel for conducting the orchestra & my lab members @ljiresearch for all the EM.
Electron microscopy, of #CoVIC therapeutic IgG in complex with #SARSCoV2 spike, depicts how antibodies against key epitopes bind singly, bivalently, or bridge spikes together. Structure work led and coordinated by @LassaHunter Haoyang Li. science.org/doi/10.1126/sc…
Read 4 tweets
Throughout the pandemic, we've gotten used to the idea that most #COVID cases are "mild." The CDC says mild cases account for 80% of symptomatic infections.

Some people hear this and think it's not worth worrying about. Are they right?

A thread on what "mild" really means. (1) Image
In common language, the word mild usually describes something of minor importance. For example: health and medical websites often describe the cold as a "mild viral illness."

The implication is that while you may feel crummy, it really isn't a big deal 🍪 (2)
In the case of #COVID, this isn't quite right. Here the common definition of mild and the medical definition differ significantly.

Their confusion is a failure of communication. People are quick to underestimate the disease. They've taken "mild" as a synonym for unimportant. (3)
Read 47 tweets
Prendendo in considerazione solo il livello di anticorpi neutralizzanti per determinare efficacia dei vaccini anti #COVID19 ci vorrà sempre una dose di vaccino ogni 6 mesi, perchè gli anticorpi neutralizzanti tenderanno sempre a decrescere nel tempo.. A questo punto sorgono
3 importanti quesiti scientifici che sarebbe opportuno chiarificare bene:
1) I vaccini inducono anche maturazione di cellule B della memoria, che produrranno altri anticorpi neutralizzanti se un vaccinato viene a contatto con il virus in futuro, e cellule T della memoria.
Queste due componenti del sistema immunitario potrebbero garantire una protezione a lungo termine. Perchè basare la decisione di dare un boost solo su durata degli anticorpi neutralizzanti? La popolazione generale ha davvero bisogno di un boost ogni 6 mesi?
Read 9 tweets
For anyone who doesn't want to do alignments, here are spike amino-acid mutations separating #SARSCoV2 from newly discovered bat CoV BANAL-20-52, which is #SARSCoV2's closest known relative in spike.

Mutations as #SARSCoV2 Wuhan-Hu-1 to BANAL-20-52 in #SARSCoV2 numbering. (1/6)
There are 16 amino-acid substitutions across the 1273-residue spike.

In addition, there is an indel at the furin cleavage site, since like all other known bat sarbecoviruses, BANAL-20-52 lacks the furin cleavage site found in #SARSCoV2. (2/6)
For comparison, Beta and Delta #SARSCoV2 variants each have 7 amino-acid substitutions relative to Wuhan-Hu-1.

So BANAL-20-52 spike about twice as diverged as current #SARSCoV2 variants are from early #SARSCoV2, *plus* of course BANAL-20-52 lacks the furin cleavage site (3/6)
Read 7 tweets
Perché misurazione di anticorpi neutralizzanti dopo vaccino non sono unico parametro da tenere in considerazione per misurare efficacia dei vaccini anti #COVID19 ?
1) anticorpi neutralizzanti decrescono nel tempo
2) ruolo cruciale delle cellule B della memoria:
Il vaccino induce la maturazione di cellule B della memoria, che sono le cellule che produrranno altri anticorpi neutralizzanti se dovessimo venire in contatto con il virus dopo il vaccino.
3) maturazione delle cellule B della memoria indotta dai vaccini permette al soggetto
Vaccinato di produrre diversi anticorpi neutralizzanti che lo proteggono dalle diverse varianti del #SARSCoV2, inclusa la delta.
CONCLUSIONE: anche se dopo pochi mesi dalla vaccinazione si hanno pochi anticorpi neutralizzanti, si è ancora protetti, perché vaccino induce
Read 5 tweets
From @linseymarr excellent piece in @IDSAInfo CID journal, re transmission of respiratory viruses

"This dichotomy overlooks the reality that respiratory droplets of all sizes, incl aerosols, are most concentrated close to the source (i.e., the infected individual) and that..."
"exposure at all but uncomfortably close distances is dominated by inhalation rather than the impaction of large droplets that are sprayed onto mucous membranes"

Why does this all matter? Because functionally it changes the type of protection that is most needed
And it is critical to acknowledge that there has a been a paradigm shift on this topic.

At my old stomping grounds @BrighamWomens our excellent infection prevention team shifted their views over time, as more evidence emerged that short-range aerosols contributed the most
Read 8 tweets
¿Se acaba la pandemia?
¿Cual es el Futuro de la Pandemia en el Ecuador?
Pues aquí les dejo algunos datos y cuales serian mis proyecciones en relación al "fin de la Pandemia" o cuando alcanzaríamos el "equilibrio endémico"
HILO
Primero, debemos entender que actualmente la situación del Ecuador es mucho mejor que la situación de otros países, inclusive paises con más vacunación ¿Por que? por q nosotros no solo vacunamos rápido, nos contagiamos previamente y nos contagiamos mucho
Actualmente las muertes en Exceso han bajado a niveles prácticamente pre-pandémicos, las muertes en exceso son un buen indicador de la situación del país y hoy por hoy hemos tenido días enteros sin muertes por COVID19 tal cual lo predijimos gk.city/2021/07/14/ent…
Read 17 tweets
Alternative wissenschaftliche Meinungen, "Experten", YouTube Videos & wissenschaftlicher Diskurs - ein thread: Ich bekomme oft als Gegenbeweis zu meinen Aussagen Links zu Youtube-Videos geschickt, mit angeblich hochrelevanten Erkenntnissen zu #SARSCoV2 #COVID19, oft zur #Impfung
Dazu muss ich zunächst klarstellen: Kein Wissenschaftler, wirklich keiner, informiert sich auf YouTube. Wirklich nicht. Auch primäre Studiendaten/neue Forschungsbefunde/ wissenschaftlicher Diskurs finden sich dort nicht. Youtube spielt im wissenschaftlichen Umfeld keine Rolle.
(Ich spreche hier von primären Studien/Forschungsdaten, Erklärvideos, Mitschnitte von Wissenschaftssendungen, die sich auf nachprüfbare Daten beziehen etc. meine ich natürlich nicht.) Bei diesen Videos treten oft "Experten" auf, teilweise sogar mit Hintergrund in Medizin/Mikrobio
Read 12 tweets
Ansicht, die ich nicht teile: Ja, nach Beendigung der Maßnahmen inclusive Masken werden saisonale Erreger incl. #Grippe zurückkommen - wenn dies aber NICHT im Winter 21/22 geschieht (nur 50% gg #SARSCoV2 geimpft + hochinfektiöses #Delta), profitieren alle 20min.ch/story/masken-l…
Vor saisonaler Grippe schützt eine Impfung, die bald für 2021/22 verfügbar ist - der Vorschlag, dass sich nun Menschen mit Grippe anstecken sollen, um vor Grippe geschützt zu sein, ist sicher wenig sinnvoll. Bei baldigem Rückzug in Innenräume ist mit Anstieg von #SARSCoV2
zu rechnen. Eine zeitgleiche Welle von Grippe, RSV und #COVID19 wäre für die Kliniken katastrophal. Ebenso schützen Masken vor Impfdurchbrüchen. Wir sollten alles versuchen, diesen Winter die Zirkulation von #SARSCoV2 & #Influenza möglichst gering zu halten.
Read 5 tweets
'Operation #Lockstep. Suomessa on meneillään ulkovallasta organisoitu, #pandemia'ksi naamioitu talousterrori-isku. Petollisin vihollinen löytyy oman maan sisältä.
- #SARSCoV2 on pelkkä tietokonemalli, 'in silico'.
Mitään todellisia viruksia ei ole koskaan löydetty, mistään. ImageImage
Vaikka @THLorg on käskytetty väärentämään rikollisin tavoin kuolinsyytilastoja Covid-kuolemiksi, todellisuudessa ihmiset elävät keskimäärin pidempään kuin ennen kuviteltua, 'in silico' virusta.
-27.12.2020 alkaneet rokotekuolemat merkitään koronakuolemiksi
Image
Read 7 tweets
👦🏻👧🏼FUERON VECTORES SILENCIOSOS IGNORADOS D ESTA PANDEMIA DD PRINCIPIO:

🦠 Pediatrics🇨🇭ha admit q infec infantil se permitió dd el ppio

🦠se sabía q había niños gravemt afect y no había💉para proteg a padres,abuelos y maestros

🦠figura fund a controlar cómo centinelas d virus
👧🏼👦🏻NIÑOS/ADOLESCENTES VECTORES /RESERVORIO EN ESTA PANDEMIA:

👉🏻al igual q en otros Corona🦠animales
👉🏻inviable terminar con pandemi a sin profilaxis 💊en este grupo d edad

#FollowTheScience #VeterinariosAlFrenteDeLaPandemiaYa
👧🏼👦🏻RESERVORIO VIRAL EN NIÑOS y ⬆️⏱DE PANDEMIA SIN TERAPIA ANTIVIRAL TEMPRANA
Read 11 tweets
Statt unwissenschaftlicher Spekulationen zu fiktiven Zukunfts-Varianten als neustes Schein-Argument für die Kinder-Durchseuchung, sollte man vielleicht lieber einmal über die zeitnah zur Verfügung stehenden Impfstoffe U12 sprechen & deren Versorgung vorbereiten #SARSCoV2 #COVID19
Natürlich ist es sinnvoll, so viele Infektionen wie möglich zu verhindern, bevor der Impfstoff in wenigen Monate kommt. Schwere Komplikationen wie #PIMS als individuelles Problem zu sehen statt sich für Infektionsschutz einzusetzen finde ich ethisch höchst fragwürdig
Zudem würde man sich dringend eine Überarbeitung der aktuellen Stellungnahme der Pädiatrie Schweiz wünschen, mit korrekter Zitation von Studien, Quellen zu den genannten Seroprävalenzen & Erklärung zum tatsächliche Hintergrund der Empfehlungen, der sich anscheinend ständig ändert
Read 6 tweets
A @CellCellPress commentary yesterday entitled "Keeping Pace with the #SARSCoV2 Variants" states
"The evidence so far suggests that effectiveness against hospitalizations and symptomatic illness is highly preserved against Delta" cell.com/cell/fulltext/…
I'm calling it out. /1
For several weeks dating back to July, we have seen protection of vaccination for symptomatic infections drop down from >90% to <40% in Israel which was refuted, attributed to poor analysis, Simpson's paradox, and many other objections to @IsraelMOH reports /2
Those reports were since corroborated by others including @KPSCalResearch, @PHE_uk. Qatar and many other. But they were ignored and denied. /3
Read 8 tweets
Niveles elevados de glucosa en sangre (hiperglucemia) en pacientes con #COVID19

Abro 🧵👇🏼

1/15

#SARSCoV2 #Diabetes #Glucose
Primero algunos (4) conceptos:

1️⃣ Insulina

Es una pequeña proteína producida por el páncreas. Le indica a nuestras células que deben absorber la glucosa que les llega a través del torrente sanguíneo

2/15

#Insulin #pancreas #metabolism
2️⃣Adiponectina

La adiponectina es una hormona producida por las células que almacenan la grasa (adipocitos), tiene dos funciones principales: hacer que las células sean más sensibles ante la insulina, y...

3/15

#FatTissue #Endocrinology #Hormones
Read 16 tweets
1/ Household transmission of #SARSCoV2 in children & adults

This new @PHE_uk study was pre-Alpha, pre-Delta & pre-vaccine but provides important insight into household infection & transmission risks in kids & adults

Here’s what the study found … 🧵

👉 journalofinfection.com/article/S0163-…
2/ The study followed up 452 household members of 181 PCR-confirmed adult & child cases in England during Mar-Nov 2020.

Nasal swabs taken for #SARSCoV2 PCR at baseline & Day 7.

#SARSCoV2 Antibodies tested at baseline & Day 35 to detect symptomatic + asymptomatic infection Image
3/ 91/431 (21%) contacts were PCR +ve & 180/383 (47%) were antibody +ve at day 35 👉 194/431 (45%) contacts had PCR +/- antibody evidence of infection

After excluding 55 households with prior/co-primary cases & PCR -ve asymptomatic contacts, 75/248 *(33%)* contacts were infected
Read 8 tweets
Sept 2021
Arg: bat origin
researchsquare.com/article/rs-871…
Counter: Spillback infection by @Daoyu15
"destruction of the furin site & the change [observed in] Q498H indicates that S1 are unable to assume #SARSCoV2 specific changes while in a bat - they are destroyed by the immune system"
"Substantial changes (hypermutation) are required for bat"

"Should be noticed that SARS-CoV-2 clade of Sarbecoviruses have much higher rate of genetic mutation both in bats (clade from ZC45) and in humans (VOC changes) compare to SARS-CoV (Shitou cave)."
"This (as well as the cancer patient cases) permit fragments of it to evolve extremely rapidly especially when conditions were unfavorable (mouse adaptation serial passage, immunity in bats (ZAP)). Due to the frequent recombinations and minimal fragments that were exchanged [..]"
Read 5 tweets
Big news from Laos @PasteurVirology relevant to the origins of #SARSCoV2:
"our results pinpoint the presence of new bat sarbecoviruses that seem to have the same
potential for infecting humans as early strains of SARS-CoV-2."
MORE

researchsquare.com/article/rs-871…
2/
"People working in caves, such as guano
collectors, or certain ascetic religious communities who spend time in or very close to caves, as well as
tourists who visit the caves, are particularly at risk of being exposed. Further investigations are needed to
assess..."
MORE
3/
"...if such exposed populations have been infected by one of these viruses, if these infections are
assoc'ed w/symptoms, & whether they could confer protection against subsequent #SARSCoV2
infections."
AND, they found, "sequences very close to
those of the early..."
MORE
Read 8 tweets
In today's hearing @US_FDA on @pfizer request for approval of 3rd #COVID19 #booster #vaccine the company presented data on its original 2020 study volunteers, many of whom originally got placebos. All those people were eventually given 2 doses of vax, but months after the..
MORE
2/...matched study pool that was vaxed from the start. This created a staggered time set for looking at duration of immunity, and then comparing impact of giving all of them a 3rd dose. They looked at protection against original (WT) form of #SARSCoV2 & beta (SoAfrica) type.
MORE
3/ The @pfizer conclusion is that #vaccine efficacy definitely wanes over time, a 3rd dose works to boost it, said dose is safe and powerful. Company said 1.8 million more cases of severe #COVID19 wld occur in USA this year w/out 3rd dosing.
MORE
Read 5 tweets

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