Discover and read the best of Twitter Threads about #anosmia

Most recents (13)

#LongCOVID19 thread.
Even only #chronicSmellingLoss #Anosmia can be devastating emotionally:
Affected people loose any enjoyment in domains like food, ignore bad smelling warnings of many hazards, can become anxieux about body odours or house odours they aren't aware of ect.1/
Besides, a #MaxPlanKInstitute team got data suggesting #chronicSmellingLoss means brain access: " #SARSCoV2 can enter the nervous system by crossing the neural–mucosal interface in olfactory mucosa..penetrating defined neuroanatomical areas.."2/ #LongCOVID
nature.com/articles/s4159…
NB: Authors also suggest the existence of "other mechanisms or routes of viral entry into the brain " As we were able to detect #SARSCoV2 RNA in some individuals in CNS regions that have no direct connection to the olfactory mucosa..." #LongCOVID 3/
nature.com/articles/s4159…
Read 15 tweets
I'm a 30-year-old doctor and I tested #positive for #COVID19 – I caught it last week.

Let me tell you, it hasn't been fun.

🧵
It started off with vague symptoms: a bit of a headache, some lower back pain. But by the end of the day I was coughing, I felt feverish, and I measured a temperature of 38.5°C. I started isolation and told all my contacts about this. Did some online shopping.
I could get a swab the following day through the hospital I work for. Testing happens in a secluded hospital building, so I had to physically go there whilst isolated. I waited for my temperature to drop and then I cycled through London with a mask on.
Read 15 tweets
Een aantal maanden verder in de crisis door #COVID19. Wat is er ondertussen allemaal nieuw bekend in de wetenschap🔬🧬?

Een samenvatting en duiding aan de hand van literatuur en populair wetenschappelijk nieuws die ik de afgelopen maanden heb opgepikt in zo'n ±110 tweets. 👇🏻
Wat ik ga in grote lijnen ga behandelen:

▪️Huidige status
▪️Complotten
▪️Testmethodes
▪️Symptomen en ziekteverloop
▪️Immuniteit
▪️Risicofactoren
▪️Verspreiding en besmettelijkheid
▪️Vaccins en medicijnen
▪️Mondkapjes
▪️Privacy
▪️Neveneffecten van de maatregelen
Ik pretendeer geen expert te zijn, want dat is niemand bij een nieuwe ziekte. Maar ik probeer het vanuit mijn achtergrondkennis begrijpelijk te maken voor de leek.

Net zoals in deze draad van maart waar ik toen beknopt alle relevante info in plaatste.
Read 113 tweets
I can't smell. Not because of cold or COVID. I can't smell by birth. It is called #CongenitalAnosmia (CA). In a chat with the @AbhiSuryawanshi, the only other Indian i know who accepts to not being able to smell by birth, told me that it is classified as a #RareDisease
As a kid i thought i will learn to smell, just like how anyone learns to speak or read. I acted like i could smell. I covered my 👃 along with all my classmates and blamed someone for the fart. It was my little secret that I can't smell. No one could tell & no one will believe.
I think my grandfather also suffered with #Anosmia. He struggled with smells but he never spoke about it. I think the reason he went to the other extreme of selling incense sticks and talcum powder to prove he was not. For obvious reasons, the businesses failed big time!
Read 14 tweets
People sick with #COVID19 report losing their sense of taste or smell. Take a look at these google search trends.. #anosmia
Together with a group of other experts; scientists, clinicians and patient advocates @GcChemosensR, I wondered…🤔
Is it #taste or #smell, because they are so easily confused? Even by experts...
Read 17 tweets
Here is my personal peer-review of #ENECovid19 project on the #seroprevalencia #seroprevalence of #COVID19 in Spain. Excellent work and document released yesterday by @SaludISCIII @sanidadgob @CienciaGob ciencia.gob.es/stfls/MICINN/M… (thread) 👇
Some background: These are preliminary results based on reading the IgG band of a rapid test for 60.897 participants. 97,55% of these participants did not have RT-PCR test for #COVID19.
The chosen rapid test is Orient Gene IgM / IgG from the company Zhejiang Orient Gene Biotech
According to the manufacturer, a sensitivity for IgM and IgG is 88% and 97% respectively, and a specificity of 100%. 3. Importantly, the degree of agreement for IgG measured by rapid test and by immunoassay in 16,953 samples analyzed so far is 97.3%.
Read 12 tweets
#Reporte #COVID19 Hoy fue la semana en la que atendí a la mayor cantidad de casos (todos ambulatorios) y puedo compartir lo siguiente:
1.- El #cuadroclínico NO necesariamente es #respiratorio.
2.- Hay muchos casos que inician con mal estar gastrointestinal. 👇👇(va el hilo)
* No sólo es diarrea, puede terminar en un cuadro de abdomen agudo por #necrosis intestinal por #trombosis (@carrillo_jc1101)
3.- Los pacientes cursan con la #tos característica, la cual no necesariamente es productiva, es más #irritativa, aunque si expectoran.
4.- El malestar general se acompaña de dolor semejante al producido por #traumatismos musculares principalmente en #muslos y en piernas y pies similares a dolores #neuropáticos.
5.- Hay una #cefalea (dolor de cabeza) intensa que genera #fotofobia (la luz les irrita) y postración.
Read 5 tweets
1/ THREAD 7: Viral Latency and a Hematogenous Route to CNS?

Is it even conceivable that #SARSCoV2 could establish latency in sensory ganglia (like trigeminal ganglia in HSV1) and reactivate to cause recurrent disease as respiratory droplets could enter the eyes, nose, and mouth?
2/ Specifically, talking about the peripheral nerves of the eyes, nose and mouth here. And thinking along the lines of why clinicians are seeing the loss of smell and altered taste in so many patients. Please remember, I am not a #virologist or an infectious disease specialist!
3/ HYPOSMIA DATA:
Both the American Academy of Otolaryngology - Head and Neck Surgery AAO-HNS and ENTUK have classified loss of smell and altered taste as significant symptoms in #COVID19. #Covid19UK

entnet.org/content/corona…

entuk.org/sites/default/…
Read 22 tweets
1/ Based on my last 4 threads, I have a new hypothesis:

#SARSCoV2 is a neuroinvasive virus perpetuated by respiratory droplets to the mucus membranes of the eyes, nose, and mouth with 3 major insults

@NeurologyToday @JAMANeuro @ASlavitt @mlipsitch @larrybrilliant @Datta_Lab Image
2/ These 2 papers were key:

The neuroinvasive potential of #SARSCoV2 may play a role in the respiratory failure of #COVID19 patients
onlinelibrary.wiley.com/doi/pdf/10.100…
3/ Non-neural expression of #SARSCoV2 entry genes in the olfactory epithelium suggests mechanisms underlying #anosmia in #COVID19 patients
biorxiv.org/content/10.110…
Read 13 tweets
THREAD
1/ I hope no one believes that I am an expert on #SARSCoV2 or believes that “I” think I am an expert on #COVID19

In an effort to contribute to the greater good of this #pandemic pandemic, I have been trying to utilize my clinical research experience and help remotely
2/ ...in lieu of actively seeing patients on the front line.

My role has been asking questions, synthesizing ideas, and hoping to catalyze discussion amongst colleagues. Am I actually helping anyone? Who knows? lol

So again, more thinking, more questions… (#neuro #ENT focus)
3/ I was thinking about those 2 neurological cases:

24yo M, Meningitis/Encephalitis -NP swab, +CSF (JAPAN)
sciencedirect.com/science/articl…

58yo F, Acute Hemorrhagic Necrotizing Encephalopathy +NP swab, CSF unable to be tested for SARSCOV2 (USA/MI)
pubs.rsna.org/doi/10.1148/ra…

Bizarre.
Read 29 tweets
Pause for Thought for #alltheosmias. With smell/taste loss being a feature of Covid-19, it’s’ been a busy week here at Fifth Sense HQ (which is now at my kitchen table). Just wanted to take a minute whilst we are all physically distant from each other and send a message of
sincere thanks from all of us to all of you. There are now over 5000 of us in our social media communities. Without you, it would be impossible to support each other, share experiences, work towards treatments, develop self-management tools, contribute to important research and
raise awareness about smell and taste disorders whatever they are, however they were caused and however long for. #Stayhome, #staysafe. ❤️ #anosmia #hyposmia #parosmia #phantosmia
Read 3 tweets
⚠️Doctors warn that #anosmia (loss of sense of smell) and #ageusia (diminished sense of taste) have emerged as peculiar telltale signs of #COVID19 and are possible markers of #coronavirus infection.

In #Wuhan, ENT and eye doctors DIED in large numbers.

nytimes.com/2020/03/22/hea…
U.K. physicians cite reports from other countries indicating that significant numbers of #coronavirus patients experienced #anosmia: in #SouthKorea, 30% of 2,000 patients who tested positive for #COVID19 had anosmia as their major presenting symptom (these were MILD cases).💥
A high rate of transmission of #COVID to ENT doctors has been reported from #China, #Italy and #Iran, many resulting in DEATH.

In the "hot zone" of New Rochelle NY, patients who had first complained of #anosmia later tested positive for the #coronavirus.🧐
Read 5 tweets
With the #COVID19 outbreak, it is important to use language responsibly. Here is the first entry of our new #ContagiousWords series, defining the buzzwords and terminology dominating today's conversation. #Pandemic #PandemicsCost
@ilariacapua Language is powerful, so we must be sure and accurate in the ways we communicate science. #Epidemic #ContagiousWords #COVID19
Read 64 tweets

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