Discover and read the best of Twitter Threads about #pasc

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Ein Artikel der das Problem #Zytokinsturm❗️bei einer #Covid Infektion gut zusammen fasst! Oftmals liegt hier die Hauptursache für #longcovid #mecfs oder das #postvacsyndrom.

Lesempfehlung 👏🏻

Kleine Zusammenfassung gibt es im Thread 🧵 1/7

deutsche-apotheker-zeitung.de/daz-az/2020/da…
Bei #covid beginnt der Zytokinsturm lokal und breitet sich dann über den Blutkreislauf aus. Es kommt zu Fieber, Schwellung, Rötung, Müdigkeit Übelkeit, starken Entzündungsreaktionen im gesamten Körper, auch an den Gefäßinnenseiten der Patienten. > #Endothelentzündung

2/7
#Wissenschaftler vermuten, dass der Zytokinsturm das Ergebnis einer „zweiten Welle“ des immunologischen Geschehens sein könnte, da Patienten in späteren Krankheitsstadien plötzlich eine akute Verschlechterung erleiden [England 2020, Felsenstein 2020, Jamilloux 2020]. #PASC

3/7
Read 7 tweets
/🧵II. Why is health not “binary” (alive vs. seriously sick / dead)?

This thread is part 2 of 7 of the mother thread #FreshStart2PublicDebate.

It is about a nuanced understanding of health in terms of a complex state and about the effect of SARS-CoV-2 infections.
/ The state of health involves, for example, the state of the microbiome and it is characterized by a degree of inflammation / oxidative stress, and it is defined along the spectrum of aging / senescence.
/ Here is for revisiting the risks associated with a #SARSCoV2 infection.

The risks can be approached by dividing the time span after an infection into three phases:

The acute phase after infection
The 12 week window post-infection phase
The long term phase (3 months +)
Read 134 tweets
#1 I am a very private person who dislikes social media, but I have finally decided to use my voice to raise awareness of long covid and other post infectious diseases that don’t get enough attention. Here’s my story. #ZiekBOOS I got infected with #covid19 in june 2022.
#2 It started like a bad flu, I wasn’t hospitalized. 2 weeks later I woke up with extreme fatigue, headache, dizziness, heavy legs and pressure against my chest. I was barely able to walk for 5 min. Then I lost my sense of smell&taste. I understood that I might have long covid.
#3 3 weeks after my infection I consulted a GP. The GP sent me home with the message that there’s nothing they could do and advised me to take vitamin C supplements. I just had to wait it out for a couple of ‘months or years’.
Read 20 tweets
Reduziert #Paxlovid bei #COVID19 das Risiko von #LongCovid und anderen späteren Folgen = #PASC?

In dieser Studie führte die Einnahme von Paxlovid innerhalb von 5d nach pos COVID-Test zu 26% weniger PASC nach 90d (kein Paxlovid 9,43/100 vs. mit Paxlocid 7,11/100 Personen).

1/
Auch Todesfälle (minus 48%) und Hospitalisierungen (minus 30%) waren nach Paxlovid deutlich seltener.

Diese Reduktion von #PASC bzw. #LongCovid-Symptomen betraf eine Reihe verschiedener Symptome von Herzerkrankungen über Fatigue bis zu neurokognitiven Erkrankungen.

2/
Die Reduktion von #PASC / #LongCovid war unabhängig von Alter, Geschlecht und Impfstatus zu sehen.

Bevor's zu euphorisch wird:
- Preprint
- Keine prospektive Medikamentenstudie, sondern eine Studie mit Gesundheitsdaten bei US-Veteranen, d.h. großteils älteren, weißen Männer.

3/
Read 4 tweets
Dieser Artikel in der Bild ist ein Meisterwerk, denn Deutschlands Top Virologe Streeck löst darin alle, das neue, postpandemische Normal noch trübende Probleme.
1/x
Screenshots via Bild
Streeck sagt sinngemäß: Wellen entstehen von alleine und brechen von alleine und weiter:
Maßnahmen können Kurven nur abflachen, niemals brechen.

Heißt übersetzt: Wir haben keinen Einfluss auf das Geschehen und wenn wir uns einschränken und abmühen ist der Effekt minimal.
2/x
Hier sagt er, dass es völlig egal ist wie viele Menschen sich wie häufig infizieren, da es nur einen wichtigen Indikator gibt, nämlich die Kliniküberlastung, ganz so als gäbe es keine
#PASC und kein #LongCovid.
3/3
Read 12 tweets
🔴📩📢Dans son 1er avis, le conseil scientifique du gouvernement #COVARS, dont les missions sont de travailler aux enjeux d’anticipation et de prévention des crises sanitaires et leurs conséquences sur la population, associe la maladie du #CovidLong,
🧵1/👇👇
#apresJ20
tout comme les syndromes post-infectieux à la seule hypothèse #psychosomatique (“troubles fonctionnels”) sans base scientifique fondée. 2/
En notre qualité d’association de malades du Covid long, il est de notre devoir de faire remonter notre divergence d’approche avec le #COVARS sur ce point. 3/
Read 34 tweets
Don't Leave Me This Way~HIV~Love Hangover

The SARS-CoV-2 virus and its Sp!ke Protein (SP) contain gene sequence homologs of other lethal organisms.

One of these is HIV.

It's interesting to compare their shared pathophysiological mechanisms.
(Research🧵, hit "Show replies" at the end to see more)

Dr Richard Fleming, FlemingMethod.com explains the evidence Montagnier found, including 18 gene fragments similar to HIV and SIV, on SARS-CoV-2.
SARS-CoV-2 like HIV, suppresses the innate immune system
forbes.com/sites/williamh…
Lymphopenia
nature.com/articles/s4139…
Read 14 tweets
🧵
“What Is #LongCOVID—and How Are We Going to Solve It? This potentially life-altering post-viral syndrome may have affected as many as 23 million Americans (and counting)”

Contains quite a bit of discussion about #MEcfs

prevention.com/health/health-…

#CFS #PwLC #PwME #CFSME

1/ Image
2/

“We’re starting to gain more understanding of what’s driving #longCOVID & who is most at risk, & the more we understand, the more it will help us get a grip on similar chronic illnesses, like #MECFS, that have been largely ignored for far too long” - @VirusesImmunity

#CFD
3/
“In those who felt ill from #postCOVID19 syndrome for at least six months, the most common symptoms were fatigue, cognitive dysfunction, & post-exertional malaise (a triad that besets many people with #MECFS), according to the study” of 3762 patients by @patientled

#LongCovid
Read 12 tweets
Of all the horrors of #COVID, the prospect of millions of people with with #LongCovid is one of the worst. But it's been hard to get a handle on clinically.

A 🧵 on some new results that may shed light on why, and offer some possible ways forward doi.org/10.1101/2021.0… 👇
1/n
First, some background. #LongCovid has been recognized for a while, and has some devastating manifestations like #BrainFog theatlantic.com/health/archive…, but the clinical definitions have been... let's say, fluid 💦 cdc.gov/coronavirus/20…

2/n
There are no definitive tests 🧪 to diagnose #LongCovid. In fact, one study was not able to find any clinical differences between people with uncomplicated recovery and those with post-acute sequelae of COVID (#PASC - another name for LC) doi.org/10.7326/m21-49…

3/n
Read 20 tweets
1/ 🧵Die Pandemie sei laut @stohr_klaus vorbei, wenn die gesundheitlichen Auswirkungen von #Covid19 denen von anderen Atemwegserkrankungen gleichen.

Das klingt ansprechend. Das ist was wir wollen.

Aber hier verbirgt sich noch ein Missverständnis.

2/ Zunächst nur am Rande:

Eine Pandemie ist dadurch gekennzeichnet, dass ein Erreger in globalen Wellen auftritt.

Es geht in diesem Kontext um die gesundheitlichen Auswirkungen von #SARSCov2, also in erster Linie um #PASC (post acute sequlae), also um #LongCovid.
3/ Das RKI schätzt, dass 10 Prozent aller Infizierten an #LongCovid leiden.

tagesschau.de/wirtschaft/ver…
Read 17 tweets
#LongCovid and #MECFS are not psychosomatic diseases.

This thread 🧵 lists studies in which neurologic, immunologic, cardiovascular and other physical abnormalities were found in #LongCovid and #MECFS patients.

The thread will be gradually expanded by further studies.

1/X
Persistent capillary rarefication in long COVID syndrome

“COVID-19 leaves a persistent capillary rarefication even 18 months after infection.”

#LongCovid #SARSCoV2 #COVID19

2/X
Prevalence of symptoms, comorbidities, fibrin amyloid microclots and platelet pathology in individuals with Long COVID/Post-Acute Sequelae of COVID-19

“Microclots […] provide a ready explanation for the symptoms of #LongCovid /#PASC.”

3/X

cardiab.biomedcentral.com/articles/10.11…
Read 12 tweets
Finally out! ⁦@ArditiMd
”…continuous & prolonged exposure to the viral SAg-like & neurotoxin-like motifs in SARS-CoV-2 spike may promote autoimmunity leading to the development of post-acute COVID-19 syndromes, including MIS-C and #LongCovid…” frontiersin.org/articles/10.33…
In 2020, many of us #LongCovid patients begged the medical/research community to look into the connections bw MIS-C and LC. The gap (weeks) bw acute illness and LC onset was similar, as well as many symptoms - acute neuro, persistent fevers, GI, rashes, conjunctivitis etc etc.
”MIS-C shares striking clinical similarities with toxic shock syndrome (TSS), which is triggered by bacterial superantigens (SAgs). The remarkable similarities between MIS-C and TSS prompted a search for SAg-like structures in the SARS-CoV-2 virus…”
Read 28 tweets
#SPRINGER publiziert: >75% der #Covid Patienten haben 6 Monate nach Infektion eine Beeinträchtigung mindestens einer kognitiven Fähigkeit - #Psychatrische / #neurologische Auffälligkeiten am häufigsten! :
"Eine kürzlich durchgeführte systematische Überprüfung von 57 Studien mit #COVID-19-Überlebenden (n = 250 351) ergab, dass der mediane Anteil der COVID-19-Überlebenden, die mindestens eine #PASC (post-acute sequelae of COVID-19) erlitten, 54 % nach einem Monat (kurzfristig),
55 % nach 2-5 Monaten (mittelfristig) und 54 % nach 6 oder mehr Monaten (langfristig) betrug [2]. Die häufigsten Folgeerscheinungen waren neurologische und psychiatrische Symptome.
Read 5 tweets
Further evidence of persisting SARS-CoV-2 spike protein in #PASC #LongCovid patients, now if we can just #TreatLongCovid !
@harvardmed

medrxiv.org/content/10.110…
”In conclusion,
the presence of circulating spike in PASC patients up to 12 months post-diagnosis strongly suggests that SARS-CoV-2 viral reservoirs persist in the body…”
”Additionally,
the detection of spike in a majority of individuals included in our PASC cohort
provides strong support for the use of spike as a biomarker for PASC.”
Read 14 tweets
7% of participants displayed a previously unidentified set of symptoms that included cognitive deficits, tremor and difficulty balancing. The authors labeled the phenotype (with) Tremor, Ataxia and Cognitive deficit -- PASC-TAC for short. #PASC nbcsandiego.com/news/local/hal…
”At the 6-month follow-up, predominant symptoms shifted from headache and fatigue to memory impairment and decreased concentration. This trend has not been previously reported longitudinally in neuro-PASC.”

onlinelibrary.wiley.com/doi/10.1002/ac…
”We reported 4 patients with no prior neurologic disease who demonstrated a pattern of incoordination coupled with cognitive dysfunction (PASC-TAC). Longitudinal follow-up of these patients demonstrated slow recovery…”
Read 5 tweets
1/ 🧵 What’s in a name? ‘Long Covid’ ‘post-acute Covid syndrome’. What does that make you think of? Tiredness? #longcovid is covid related THROMBOTIC VASCULITIS. Sounds serious, right? ✅ 🤷🏻‍♀️
2/ thrombotic vasculitis is when the spike protein makes your blood vessels inflamed and form little clots that block small blood vessels 🩸 #MicroClots I like evidence so here you go portlandpress.com/bioscirep/arti…
3/ when your blood has little clots in it filled with amyloid it causes more Inflammation. Think of when you get a cut and the skin goes red and sore. That’s inflammation. Imagine that in your blood vessels. The oxygen in your blood then struggles to get to all the tissues. 🩸 🤒
Read 15 tweets
This important study found a significantly elevated frequency of #SARS-CoV-2-specific TNF-α-producing CD8+ T cells in patients with pulmonary #LongCovid (PASC). PASC subjects experienced an average symptom duration of over 6 months: journals.plos.org/plospathogens/…
2/ This is how the authors interpret the finding: "This increased frequency could be detected in response to peptide pools of all the #viral structural proteins in comparison to the resolved #COVID-19 (RC) cohort.
3/ Interestingly, these T cells were also significantly higher in female PASC participants compared to males, which may contribute to the higher prevalence of PASC in #women
Read 10 tweets
Australia, we need to talk — A brief critique of the @NSWHealth clinical practice guide, which dropped this week for #PASC #LongCovid: 🧵 1/n
This will be a critique from a patient perspective - I have viral-onset (non-Covid) longterm disease, #MyalgicEncephalomyelitis #MECFS - and it will be non-exhaustive because I, myself, am exhausted because of said disease. Let’s go: 2/
The @NSWHealth #LongCovid clinical guide matters because healthcare workers in australia will use this for advice on *what to do & what not to do.*
What they say directly impacts whether we *harm or help* thousands upon thousands of real people facing real hardship right now 3/
Read 24 tweets
BIG PROBLEMS with framing of new baseline study of NIH intramural #LongCovid #PASC cohort

lack of abnormalities on ROUTINE tests

no objective abnormalities

It ignores #LongCOVID similarities to #MECFS & advances in research on both, including those funded by NIH!

1/
no evidence found

evidence against

LOOK HARDER

Yes, it's a baseline study. But the pivot to discussions of depression and anxiety when abnormalities weren't easily found is jarring.

2/

acpjournals.org/doi/10.7326/M2…
This follows the HORRIFYING tendency of medicine to psychologize illness, when physiological abnormalities aren't found.

#MedTwitter

3/
Read 15 tweets
“Patients and patient advocacy groups have brought attention to the profound disability associated with post-Covid condition” #LongCovid
tinyurl.com/yf832nxd
“Children and adults with a positive #COVID19 test were more likely to receive a diagnosis for a new condition or have new symptoms in the 5 months after acute infection compared to those who tested negative for Covid-19" #LongCovidKids
“The most striking cases are the people who were absolutely healthy, got Covid, weren’t particularly sick…and now a year later are quite disabled”
Read 7 tweets


'Endemic Delusion' in Denmark - coming to a continent / country / city / town / village / house near you, if it isn't already in your living-room.



#FarFromNormal
#P100
#ElastomericBulletproof ImageImageImageImage


Q & A.

Not sure why anyone would focus on one particular continent when this happens to be a global pandemic.

When Pi?

#ButtonUp #N95 #FFP3 #GoElastomeric #P100 ImageImageImageImage
Read 272 tweets
1/🧵 How do #COVID patients suffer after the ICU?
 
This new @JAMA_current study of 246 Dutch pts shows that 3 out of 4 people had physical problems 1 YEAR LATER plus 1 in 4 have #brainfog, depression & anxiety.
 
What do we call this?

#LongCOVID #PICS
 
bit.ly/3o4djkT
2/ The paper is also discussed in @Medscape👇: “Our study shows what an impact ICU admission has on former #COVID19 pts. Even after 1 year, half are tired or experience lack of the energy to fully resume their work," says author Marieke Zegers, PhD
 
wb.md/33U9DeF
3/ I searched this paper for well-known terms like post-intensive care syndrome #PICS, #LongCOVID & even “post-acute sequelae of COVID”#PASC
 
NADA. Zip. Zilch.

Why weren’t these names mentioned? At the very least, these pts’ disabilities are DEFINITELY PICS & underestimated btw
Read 9 tweets
1/🧵 BEWARE: Mild” COVID can cause #LongCOVID‼️

@Nature study of N=147 (31 w LongCOVID) found Covid infection exerts unique & prolonged effects on our innate & adaptive immune system over 8 months later.

This may drive Long Covid.
 
go.nature.com/3ntDOQk
2/ Obviously, Acute COVID-19, caused by infection w SARS-CoV-2 is characterized by wide ranging severity from asymptomatic to fatal. Our immune response (big or little) to the virus drives the pathology that can kill us.
3/ We know that the acute infection causes pronounced immune system problems w lowering lymph cells and rising inflammatory mediators that can cause organ damage.

This is why I have to put so many people on ventilators & dialysis.

Read 8 tweets
Today I virtually lectured the residents from @BCM_PMandR & @UTHPMR about #LongCOVID.

I was touched that the residents wanted the slides & thought it was one of the most important talks of the year. Will share some in a thread 🧵 Selfie of Monica
We are still trying to figure out the pathophysiology of #LongCOVID... these are just a few of the hypothesis. But definitely inflammation and immune system dysregulation is involved.
2/ Image
We also know #COVID19 hyperinflammation and #PASC may be rooted in mast cell activation syndrome #MCAS 3/
ncbi.nlm.nih.gov/pmc/articles/P…
Read 10 tweets

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