Discover and read the best of Twitter Threads about #voi

Most recents (13)

La #variante"Nu" B.1.1.529: segue un thread con le poche info che abbiamo. Ma non c'è da andare nel panico, ve lo spiego. Iniziamo. 1/21
#COVID19
Le autorità sudafricane sono allarmate per la rapida diffusione di una nuova #variante che in tre settimane è passata dall'1 al 30% di casi, soppiantando la #Delta (attualmente predominante nel mondo). Vediamo di cosa si tratta. 2/21
Si tratta di una variante di #SARSCoV2 emersa per la prima volta l’11 novembre 2021 a seguito di tre rilevamenti in #Botswana. 3/21
Read 21 tweets
Muita gente ficou surpresa com as notícias referentes a C.1.2, uma variante possível aumento na transmissão e com algum escape imunológico anunciada pelo Inst. Nacional de Doenças Transmissíveis da 🇿🇦 e da Plataforma de Inov.e Seq. de Pesq. KwaZulu-Natal

Acompanha 🧶👇
RESUMO:
🔹Variante com características preocupantes, mas que não tem circulação global
🔹Nada nos diz que vacinas não abrangeriam ela
🔹Mais um indicativo de que o vírus está se adaptando
🔹A desigualdade de distr. de 💉 no 🌎 É UM PROBLEMÃO
🔹💉E 😷pelo amor de Deus

Detalhes👇
Não é segredo, nem novidade, que a permanência desse estado de transmissão elevado, que é construído por vários fatores, (baixa cobertura 💉, falta de adesão adequada a medidas como uso de 😷, p.ex), gera um risco de vermos novas variantes surgirem
Read 29 tweets
#拡散希望 当ラボ主宰の新型コロナ研究コンソーシアムG2P-Japanのプレプリント第3弾を、bioRxiv @biorxivpreprint に公開しました。本研究では、「注目すべき変異株 #VOI 」のひとつであり、南米で流行拡大する #ラムダ株 のウイルス学的特徴と進化動態を描出しました。1/5
biorxiv.org/content/10.110…
まず、#ラムダ株 が、ワクチンで誘導された #中和抗体 に強い抵抗性を示すことを明らかにしました。次に、ラムダ株特有の、スパイクタンパク質の大きな欠損変異(246-253欠損変異)が、このラムダ株の中和抗体抵抗性を規定していることを明らかにしました。2/5
分子系統学解析の結果、「246-253欠損変異」を持つ #ラムダ株 は、昨年7月頃に誕生し、その後南米各国で流行拡大したことが示唆されました。さらに、#ラムダ株 特有の #L452Q 変異が、#デルタ株#L452R 変異と同様に、ウイルスの感染力を増強させることを明らかにしました。3/5
Read 6 tweets
1/5 Aktualisierter #RKI-Bericht zu den #Virusvarianten (Variants of Concern #VOC, Variants of Interest #VOI) von #SARS_CoV_2:
➡️rki.de/DE/Content/Inf…

Die Darstellung basiert auf Daten aus der #Gesamtgenomsequenzierung.
2/5 Der Anteil der VOC B.1.617.2 (#Delta) nimmt weiterhin stark zu & hat sich wiederum innerhalb einer Woche verdoppelt. Diese starke Zunahme des Anteils der #Variante B.1.617.2 geht mit einer leichten Zunahme der Delta-Fallzahlen bei weiterhin abnehmender Gesamt-Inzidenz einher.
3/5 Die aktuell vorliegenden Daten zeigen, dass die #VOC Delta sich gegenüber den anderen Varianten, insbesondere auch gegenüber der bisher dominierenden Variante B.1.1.7 (#Alpha), durchsetzen wird.
Read 5 tweets
A metal ion orients SARS-CoV-2 mRNA to ensure accurate 2′-O methylation of its first nucleotide
» doi.org/10.1038/s41467…
The #SARSCoV2 #coronavirus is able to utilize the changes in metal ion concentrations to disguise itself in the human host body thus evading immune responses. Image
Efficacy of #clarithromycin on #COVID19 pneumonia without oxygen administration; protocol for multicenter, open-label, randomized-controlled, 3-armed parallel group comparison, exploratory trial #CAMECOVID
» doi.org/10.1101/2021.0…
Japan Registry of Clinical Trials jRCTs071210011 Image
The influence of #HLA genotype on the severity of #COVID19 infection
» doi.org/10.1111/tan.14…
A genetic link has been discovered explaining why some people catch #Covid but don't get sick. The gene is found three times as often in people who are #asymptomatic. Image
Read 199 tweets
🔝5 Concerns about #SARSCoV2 #Biology: A Call to Pause, Deliberate, and Revise Policy─This review is intended both as a basic resource and to initiate an open and critical dialog about SARS-CoV-2 biology for an independent and public call to action. jjcouey.medium.com/5-concerns-abo…
Structural basis of ribosomal #frameshifting during translation of the #SARSCoV2 #RNA #genome
» doi.org/10.1126/scienc…
A unique feature of the SARS-CoV-2 genome controls protein synthesis and presents an "Achilles heel" of the virus. Image
Brainstem neuropathology in two cases of #COVID19: #SARSCoV2 trafficking between #brain and #lung
» doi.org/10.1007/s00415…
Neuropathologic evidence strongly suggests that the pathophysiology of COVID-19 related respiratory failure includes a neurogenic component. Image
Read 213 tweets
1/4 Der #RKI-Bericht zu den besorgniserregenden Virusvarianten (Variants of Concern, #VOC) von #SARS_CoV_2 wurde aktualisiert:
➡️rki.de/DE/Content/Inf…

Daten KW6-KW12 zeigen Analysen der Erhebung des Laborverbundes, Daten ab KW15 aus der Gesamtgenomsequenzierung (KW16).
2/4 Die #VOC B.1.1.7 ist weiterhin die dominierende #SARS_CoV_2-Variante in Deutschland. Aktuell ist keine Abschwächung des hohen Anteils von B.1.1.7 zu beobachten. #B117
3/4 Neben den besorgniserregenden Varianten #VOC, gibt es einige unter Beobachtung stehende sogenannte Variants of Interest #VOI. Die VOI haben gemein, dass sie Mutationen aufweisen, die mit erhöhter Übertragbarkeit oder reduzierter Antikörperneutralisation assoziiert werden.
Read 4 tweets
Logik zum #Öffnungsplan der #Bundesregierung
Wo, wie und wie schnell infiziert man sich mit dem #Coronavirus? Solange die Regierung Entscheidungen - magels Datenlage - ohne Evidenz trifft, solange ist es Willkür, wann welche Bereiche geöffnet und andere geschlossen bleiben #Spahn
Die Mutante #B117 erreicht in diesen Tagen -in den ersten Bundesländern- ihre #Dominanz. #R steigt zeitgleich und die #Regierung erhöht per #Öffnungsplan die #Mobilität: B117, Öffnungsplan u. gesteigerte Mobilität sind drei Faktoren die logisch #R exponentiell beeinflussen können
Zeitgleich werden #Kitas u. #Schulen geöffnet, also die Versammlungsorte, vor deren Öffnung uns Experten und Ärzte aus #Israel u. Kanada warnen. Begründet wird die #Öffnung mit "Meinungen" von Wissenschaftlern, deren #Studien -manipulierte Daten- aus #Schweden zitieren #twlz #KMK
Read 243 tweets
Reducing #COVID19 #Airborne #Transmission Risks on #PublicTransportation Buses
» doi.org/10.1101/2021.0…
Wearing of #facemasks reduced the overall particle count released into the bus by an average of 50%, the dispersion distance by several feet and #aerosol particles by 84.36%. Image
🔝#SARSCoV2 Infects Human Engineered Heart Tissues and Models COVID-19 Myocarditis
» doi.org/10.1016/j.jacb…
#COVID19 can kill heart muscle cells, interfere with contraction. Details of how #coronavirus infects #heart: models of tissue damage may help develop potential therapies. Image
High-content screening of coronavirus genes for innate immune suppression reveals enhanced potency of SARS-CoV-2 proteins
» doi.org/10.1101/2021.0…
196 protein products of seven coronaviruses: the genes encoded by #SARSCoV2 are generally more potent immune suppressors than others Image
Read 236 tweets
Was machen bei steigenden Zahlen und bei wachsendem Anteil von VoC (Variants of Concern - besorgniserregende Varianten) wie #B117?
#ECDC gibt dazu klare Empfehlungen. Ob Hannovers OB @BelitOnay das gelesen hat vor Öffnungs-Forderungs-Paper Unterschrift?
H: Inz 115 & #B117 40-50%
Hier nochmal zum im Thread bleiben die "Options for Response" der @ECDC_EU .
Quelle:
ecdc.europa.eu/en/publication…➡️
3/ Die Öffnungsforderung von 17 Oberbürgermeistern, darunter #Onay will das Gegenteil.➡️
haz.de/Nachrichten/De… via @HAZ
Read 58 tweets
⚠️#Ocular #MRI Findings in Patients with Severe #COVID19: A Retrospective Multicenter Observational Study
» doi.org/10.1148/radiol…
All patients had nodules in the macular region, 8/9 (89%) had bilateral nodules, 2/9 (22%) had nodules outside the macular region. Screening needed. Image
⚠️🔝New-Onset #IgG #Autoantibodies in Hospitalized Patients with #COVID19
» doi.org/10.1101/2021.0…
An international team of researchers studying COVID-19 has made a startling and pivotal discovery: The virus appears to cause the body to make weapons to attack its own tissues. Image
⚠️🔝Patterns of myocardial injury in recovered troponin-positive COVID-19 patients assessed by cardiovascular magnetic resonance
» academic.oup.com/eurheartj/adva…
Damage to the heart found in more than half of #COVID19 patients discharged from hospital who show raised levels of troponin. Image
Read 235 tweets
Meanwhile in #France,
"the peak of this second wave is over"

(according to the President in his Adress to the Nation):
Wait... "the peak is over" doesn´t mean "it´s back to normal"!

Confinement will only fall on December 15,
if there´s less than 5.000 new cases a day.
(today it´s ~9.000).

France is disappointed.🙁

Although they certainly can make it happen.
Meanwhile in #Switzerland:
(excess mortality of the second wave is significant)

Good news: fastest decrease in infections happens in the worst hit areas now.
Image
Read 2817 tweets
As #COVID19 cases are found to spread, #Melbourne (city of ~5 million) tries to contain them by going into #Lockdown.
(The interview features the idea of a dedicated #Quarantine building - that would actually help, I guess)...
"People acting as if the pandemic was over was 'not the answer, it is part of the problem' ".

"The virus had leaked from postcodes already under the stay-at-home orders to other parts of #Melbourne."
(and beyond, it is feared).
Due to #Melbourne's outbreak, neighbouring South Australia is about to completely close it's borders to #Victoria.

(Nearly) no exceptions. And those essential few who are allowed in, will have to wear facemasks the entire time...
Read 2915 tweets

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