Discover and read the best of Twitter Threads about #Melatonin

Most recents (4)

1/ #Melatonin

The presence of melatonin in Alphaproteobacteria & 
Cyanobacteria indicates an early appearance of this multifunctional #Serotonin
derivative in the evolution of life
2/ #Melatonin

The discovery of antioxidative properties of melatonin is consistent with an ancient role of this molecule in contributing to survival under high oxygen levels or exposure to UVR.
3/ #Melatonin

Because of melatonin production in mitochondria scavenging of free oxygen radicals has likely been a primary role of melatonin in evolution originating around 2.5–3 billion years ago
Read 15 tweets
I'm not a big #tweetorial person, more a #bitesized learning guy.
But important topic + healthy peer pressure =
Let's talk about #Delirium in the ICU (#DICU)!
For the most part, this is applicable to most patients.

Q: Do you regularly assess for #DICU?
What does delirium look like?
<5% "hyperactive": EASY TO JUDGE these pts
95%: "hypoactive" or mixed: somnolent, not accepting feeds, withdrawn:
EASY TO MISS these pts

What's the big deal?
Vent time 🔼 8d
Hosp LOS 🔼 by 8d
Cognitive impairment at D/C: 50%, long term: 33%
WHAT is delirium:
😣 Altered level of consciousness (hyper/hypoactive) +
🙄 Inattention

With either:
😇 Change in cognition (who, you?, what is life?) OR
🤓 Change in perception

Easy to miss in a patient that isn't "belligerent" or "climbing out of the bed". It can be SUBTLE!
Read 17 tweets
1. thread.

Nice @FrontPediatrics paper providing guidance for docs and #pwME in the diagnosis and management of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome #MECFS

#MedEd #MedTwitter #chronicillness #chronicpain #SickNotTired
frontiersin.org/article/10.338…
2. #MECFS is commonly misdiagnosed as a #somatic disorder

#pwME "..have been humiliated or dismissed by other providers, so [doctors] will need to be.. nonjudgmental.. & acknowledge that #MECFS is not a #psychological condition but a real illness"

frontiersin.org/article/10.338…
3. #MECFS symptoms can be diverse, complex, fluctuate and overlap with many other conditions making the diagnosis difficult

This @FrontPediatrics paper lists 33 (!) co-morbidities commonly associated with #MECFS

#MedEd #MedTwitter #pwME #SickNotTired
frontiersin.org/article/10.338…
Read 8 tweets

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