Discover and read the best of Twitter Threads about #Antibodies

Most recents (24)

Gestern kam ein interessantes Interview mit Deutschlands berühmtesten Maßnahmenkritiker, der auch das Schweden-Modell favorisierte. 1/7

Mir dämmerte es erstmals was die sog. Pandemie betrifft als ich 2020 die RKI Kurve sah (erste Welle). Aus dem Ro Wert (Basisreproduktionsrate) lässt sich die Herdenimmunität berechnen, wobei Ro angibt, wie viele Menschen ein Infizierter im Schnitt ohne Maßnahmen ansteckt.
2/7
Herdenimmunität = 1 - 1/Ro

Die Formel gibt an, wie viele Menschen gegen das Virus immun sein müssen, damit eine Herdenimmunität eintritt u. sich der Erreger nicht mehr (exponentiell) weiterverbreiten kann (genau genommen ist es die Gompertz-Fkt.)
mdpi.com/1660-4601/17/1…
3/7
Read 7 tweets
Zum #Infektionsschutzgesetz (-Entwurf): Nach "Geimpften" und
"Geboosterten" kommen jetzt "frisch Geimpfte" (3 Monate) und ab Okt. wieder Masken.
#Masken(Mandate), sog. #Impfungen u. #Lockdowns wirken, aber evtl. nicht gut genug? 1/9
Why do mask mandates fail?

Haben Masken #Nebenwirkungen?
mdpi.com/1660-4601/18/8…
"Bacterial and fungal
isolation from face masks
under the #COVID‑19 pandemic"
nature.com/articles/s4159…
2/9
Umwelt(schutz)aspekte: ZDF: "Jede Minute machen wir drei Millionen Masken zu Müll."
zdf.de/nachrichten/pa…
Afrika
m.dw.com/de/wohin-mit-a…
sciencedirect.com/science/articl…
3/9
Read 11 tweets
#Infektionsschutzgesetz
Nach "Geimpften" und "Geboosterten" kommen jetzt "frisch Geimpfte" (3 Monate) und ab Okt. wieder Masken.
#Masken(Mandate), sog. #Impfungen u. #Lockdowns wirken, aber evtl. nicht gut genug? 1/9
Siehe @johndefeo (Why do mask mandates fail?)

Haben Masken #Nebenwirkungen?
mdpi.com/1660-4601/18/8…
"Bacterial and fungal
isolation from face masks
under the #COVID‑19 pandemic"
nature.com/articles/s4159…
2/9
Umwelt(schutz)aspekte: ZDF: "Jede Minute machen wir drei Millionen Masken zu Müll." zdf.de/nachrichten/pa…
Afrika
dw.com/de/wohin-mit-a…
sciencedirect.com/science/articl…
3/9
Read 9 tweets
Exciting work from @KathyYWei1, @AmeyaHarmalkar & @proteinrosh on predicting scFv developability. TLDR: transformers and CNNs can potentially help prioritise mutations sites for enhancing stability (1/5) #antibodies #machinelearning #proteineng
Context: a single-chain Fv (scFv) is an antibody construct whose heavy and light chains are linked. It's not the conventional "Y" shape molecule, and is useful for engineering / phage display, etc. See @AlissaHummer's post blopig.com/blog/2021/07/a… (2/5)
Thermostability (measured by TS50, the temperature when scFv loses binding) is weakly predicted by 0-shot and fine-tuning via transformers (ESM-1v + ESM-1b). CNNs using sequence and structural (energy) convolutions perform better (?) [hard to tell, sorry!🙈] (3/5)
Read 5 tweets
A "negative" result, but phenomenal thought piece from @naturalantibody / @antibodymap. TLDR predicting antibody-antigen interactions is pretty darn hard (1/5) #antibodies #machinelearning #alphafold

naturalantibody.com/use-case/deepm…
Predicting Ab-Ag interactions is a sub-problem of the protein-protein interaction problem. There are many facets to consider here, including but not limited to, identifying the correct antigen (let alone the correct epitope), the correct paratope, orientation, etc (2/5)
@antibodymap's team show first that true Ab-Ag pairs (i.e. those where we know the Ab binds antigen) and false Ab-Ag pairs (i.e. Ag was randomly given to an Ab), the pIDDT scores are incomparable, suggesting score-based discrimination is HARD. (3/5)
Read 6 tweets
New #Ebolavirus research shows how 2 powerful antibodies can neutralize #Ebola—and Sudan virus bit.ly/3wg9Lkz

“Finding antibodies with this breadth is important because we don’t know which virus in the genus of ebolaviruses is going to break out next."

1/🧵
To save lives, doctors need broad-spectrum therapies that neutralize as many Ebolavirus species as possible.

This @CellPressNews study shows 2 potent antibodies that can neutralize the well-known Ebola virus and Sudan virus (also responsible for large, deadly outbreaks. Graphical abstract showing ...
The team used #CryoEM to get a clear view of these two antibodies in complex with the #Ebolavirus glycoprotein.

1 antibody, called 1C11, neutralizes the virus by binding with a site on the fusion machinery the virus would normally use to enter and infect host cells. Image
Read 7 tweets
For those wondering how the newest kid on the block, LY-CoV1404 (bebtelovimab) neutralizes variants so well, including #SARSCoV2 #Omicron BA.1.1 and BA.2? The answer is – pure luck! This antibody is like Neo dodging bullets in the matrix…🍀🍀🍀
The binding mode is very similar to imdevimab (REGN10987) but bebtelovimab avoids major imdevimab resistance caused by the N440K Omicron mutation! It also avoids other mutations. Think social distancing of antibodies from mutations...
Can use this 📺 to scroll through and see #Omicron BA.1.1 #SARSCoV2 mutations and where #antibodies bind... Sotrovimab/S309, Casirivimab/REGN10933, Imdevimab/REGN10987, Evusheld (AZD8895/tixa, AZD1061/cilga), Bam (LY-CoV555), Ete (LY-CoV016), and bebtelovimab (LY-CoV1404)
Read 4 tweets
Daily Bookmarks to GAVNet 12/15/2021 greeneracresvaluenetwork.wordpress.com/2021/12/15/dai…
Well-Structured German Study Shows No Deaths among Healthy German Kids Ages 5 to 11 ⋆ Brownstone Institute

brownstone.org/articles/well-…

#MedicalStudy, #germany, #COVID19, #mortality, #children, #SchoolClosures
Fast superhighway through the Solar System discovered - Big Think

bigthink.com/hard-science/f…

#ArchesOfChaos, #SpaceTravel, #SolarSystem, ScientificDiscovery
Read 20 tweets
Neutralization data for #omicron is out. By request of @andrew_croxford, I try to explain how scientists investigate #neutralization. First, it's lab-based data. It’s impossible to directly conclude from neutralization data that #vaccines will not work anymore in the field. 1/X
@andrew_croxford Second, assays are legion! I developed one myself, which is different to the one used by the lab of e.g., @CiesekSandra, in terms of #virus, incubation times, etc. Keep that in mind if you compare two papers directly. I will explain how I did my assay. 2/X
@andrew_croxford @CiesekSandra Third, you must understand that such an assay generates data about neutralization of the virus by antibodies in the serum. These assays do not allow for measuring the effect of e.g., T cells or memory B cells.
@sailorrooscout talks about that here: 3/X
Read 25 tweets
Many thanks to the awesome ladies at @IWS_Network for the chance to share my #immigrant #womanofcolour #womaninscience👩🏽‍🔬story throughout this week as part of their Voices Without Frontiers program!
iwsnetwork.ca/voices-without…
#IWSvoices #WomenInSTEM
I was born in #Guyana 🇬🇾
➡️ Amerindian name meaning “Land of Many Waters”.
➡️small in size (<800, 000 people), rich in natural resources
➡️only English-speaking country in South America
➡️Diversity of people with amazing cultural mix @IWS_Network #VoicesIWS #WomenInSTEM ImageKaieteur Falls - world's la...Photo Source: Guyana Times
Genetically I’m Indian - ancestors brought to ‘British Guiana’ from India during colonial times to work on #sugarplantations.

Culturally I’m #Caribbean as #Guyana shares historical and cultural ties with other Anglo-Caribbean countries.

@IWS_Network #VoicesIWS #WomenInSTEM East Woman in the Anglo-Car...
Read 20 tweets
Daily Bookmarks to GAVNet 09/02/2021 greeneracresvaluenetwork.wordpress.com/2021/09/02/dai…
CEO Ridiculed for Raising Minimum Wage to $70K Has the Last Laugh

opednews.com/articles/CEO-R…

#IncomeDisparity #MinimumWage #FinancialPerformance
Cross-reactive CD4+ T cells enhance SARS-CoV-2 immune responses upon infection and vaccination

science.org/doi/10.1126/sc…

#SARSCoV2 #ImmuneResponses #infections #vaccinations #antibodies
Read 8 tweets
As a society we need to
listen to #antivaxxers more
and attack them less.
They are scared.
We don’t know why
until we listen to them.
They want to talk about their fears in the form of statements. People think w words, and often need to process ideas verbally
to sort them.
I just met a very awesome man who has an immune compromised wife.
He is scared of the vaccines.
He kept talking about Malone (quack) and the tech being too new (its not) and all the fear Fear FEAR thats been surrounding the #pandemic and #vaccine rollouts. He is scared.
We DO gain antibodies after natural infection, but they wane. And there aren’t as many of them w natural vs acquired. It takes our bodies a full week to gather troops and launch an attack.
Thats a week of gained if you already have waiting #antibodies.
So how do we communicate?
Read 5 tweets
THIS IS A GAMECHANGER
#CoronaSymptoms can be medicated maybe completely 😃😃😃
#CovidMedication
#LongCovid
#Pandemic
"Not only would it explain why steroids work in this disease, but it would suggest that we should be treating the disease more like other autoimmune diseases of the lung."
😃
Read 6 tweets
Can #SARSCoV2 #variants fully evade #vaccine induced protection? Or even natural protection?
The rapid emergence of too many different #variants shows that the virus is struggling to survive! That is why it’s changing so fast, probably, to prolong its stay in human bodies 1/
Though #vaccines may not be working perfectly against some #VOCs, but those fully vaccinated are protected against severe disease & death. No VOC can completely evade the vaccine induced protection, especially against severe disease & death! Why?.......... 2/
The #variants do not have changes in T-cell epitopes because when you are infected with a variant that evades an antibody, that variant can go to someone else and evade their antibody too. So it spreads through the population.... 3/
Read 12 tweets
Do children produce different types of #antibodies(Abs) against #SARSCoV2 than adults? 1/ Image
Yes, children mostly produced Abs aimed at #Spike protein, which the virus uses to enter cells. Adults generate similar Abs, but also develop Abs against the #Nucleocapsid protein, which is essential for viral replication 2/

pubmed.ncbi.nlm.nih.gov/33154590/
#Nucleocapsid protein is typically released in significant quantities only when a virus is widespread in the body.
What does it mean? The kids lacked nucleocapsid-specific Abs, which suggests that they aren’t experiencing widespread infection. 3/
Read 8 tweets
Daily Bookmarks to GAVNet 07/09/2021 greeneracresvaluenetwork.wordpress.com/2021/07/09/dai…
WHAT IS BITCOIN?



#tutorial #bitcoin
After the pandemic: perspectives on the future trajectory of COVID-19

nature.com/articles/s4158…

#PostPandemic #COVID19 #FutureTrajectory
Read 8 tweets
A metal ion orients SARS-CoV-2 mRNA to ensure accurate 2′-O methylation of its first nucleotide
» doi.org/10.1038/s41467…
The #SARSCoV2 #coronavirus is able to utilize the changes in metal ion concentrations to disguise itself in the human host body thus evading immune responses. Image
Efficacy of #clarithromycin on #COVID19 pneumonia without oxygen administration; protocol for multicenter, open-label, randomized-controlled, 3-armed parallel group comparison, exploratory trial #CAMECOVID
» doi.org/10.1101/2021.0…
Japan Registry of Clinical Trials jRCTs071210011 Image
The influence of #HLA genotype on the severity of #COVID19 infection
» doi.org/10.1111/tan.14…
A genetic link has been discovered explaining why some people catch #Covid but don't get sick. The gene is found three times as often in people who are #asymptomatic. Image
Read 199 tweets
🔝5 Concerns about #SARSCoV2 #Biology: A Call to Pause, Deliberate, and Revise Policy─This review is intended both as a basic resource and to initiate an open and critical dialog about SARS-CoV-2 biology for an independent and public call to action. jjcouey.medium.com/5-concerns-abo…
Structural basis of ribosomal #frameshifting during translation of the #SARSCoV2 #RNA #genome
» doi.org/10.1126/scienc…
A unique feature of the SARS-CoV-2 genome controls protein synthesis and presents an "Achilles heel" of the virus. Image
Brainstem neuropathology in two cases of #COVID19: #SARSCoV2 trafficking between #brain and #lung
» doi.org/10.1007/s00415…
Neuropathologic evidence strongly suggests that the pathophysiology of COVID-19 related respiratory failure includes a neurogenic component. Image
Read 213 tweets

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