Discover and read the best of Twitter Threads about #trials

Most recents (14)

Just a friendly reminder @moderna_tx told the @SECGov that the @US_FDA defines #mRNA as gene therapy. And called it an unprecedented new category of #medicines tho they really want that #vaccine classification anyways for liability protections & fear the public wouldn’t take it.
They know the #COVID19 #vaccine isn’t a vaccine but human #gene #therapy.
The @US_FDA #fda reaffirmed their definition of modified viral #nucleic acid that alters #CELL Jan 30th 2020 #COVID ImageImageImageImage
Read 16 tweets
#WeekendLecture
#HistoryofEVT

It’s no secret that #EVT for AIS has been a complete game changer for the field resulting in dramatic reduction in death & disability

Join us to explore the #history of EVT in collaboration with @SVINJournal, to celebrate the inaugural issue Image
Many thanks to @Mahmoudneuro, #RaulNogueira and @DiogoHaussen whose review entitled:
👉“Tx Advancements in the Endovascular Management of Stroke” celebrates the advances in #ETV

🆓 #openaccess

ahajournals.org/doi/full/10.11…
1st #Fun fact: Interventional treatment of AIS dates all the way back to 1950s‼️
Sussman & Fitch reported 3 cases of IA infusion of fibrinolytics
Didn’t work 😫. Probably because they were performed in a non-hyperacute fashion
But this laid the foundation for years of refinement Image
Read 21 tweets
Daily Bookmarks to GAVNet 09/12/2020 greeneracresvaluenetwork.wordpress.com/2020/09/12/dai…
Biodiversity scientists must fight the creeping rise of extinction denial | Nature Ecology & Evolution

nature.com/articles/s4155…

#biodiversity #extinction #denial #ecology
COVID vaccine, treatment trials create monkey shortage for science

usatoday.com/story/news/hea…

#trials #COVID19 #vaccine #monkey #shortage #consequence
Read 11 tweets
This is a letter which has been sent out by the ICMR DG yesterday. Now that multiple folks have confirmed genuineness, let me raise some issues with this letter on #vaccine #trials during a pandemic, in this case #COVID19
What are the ethical issues in this letter? Read on.
For a vaccine for which pre-clinical development is still ongoing, as per the letter itself, how can clinical trial recruitment be starting on 07th July?
And that the vaccine will be launched on 15th August? A vaccine trial completed in little over a month, efficacy pre-decided?
How were the clinical trial sites mentioned in the appendix chosen--on what criteria? eligibility? From what list? was this selection done by ICMR or by BBIL? Some of these seem to be small nursing homes/hospitals- are they the apt place to run a pandemic #vaccine trial?
Read 22 tweets
Daily Bookmarks to GAVNet 6/05/2020-2

greeneracresvaluenetwork.wordpress.com/2020/06/05/dai…

Bruno Latour, the Post-Truth Philosopher, Mounts a Defense of Science - The New York Times

nytimes.com/2018/10/25/mag…

#philosophy #postmodernism #Science
Leading with the Unknowns in COVID-19 Models - Scientific American Blog Network

blogs.scientificamerican.com/observations/l…

#models #uncertainty #DecisionMaking
Read 12 tweets
Daily Bookmarks to GAVNet 5/31/2020-2

greeneracresvaluenetwork.wordpress.com/2020/05/31/dai…

The Privacy Dial - Render-from-betaworks

render.betaworks.com/the-privacy-di…
#privacy
Investigation of a COVID-19 outbreak in Germany resulting from a single travel-associated primary case: a case series - The Lancet Infectious Diseases

thelancet.com/journals/lanin…

#coronavirus #investigation #outbreak #Germany
Because Culture Matters, There Is No One-Size-Fits-All Exit Strategy from Covid-19 Lockdowns | naked capitalism

nakedcapitalism.com/2020/05/becaus…

#capitalism #lockdown #strategy #culture
Read 12 tweets
DEBATE: Should government #policy interventions evaluated in #stepped #wedge #trials be considered ‘research interventions’ and reviewed by the research ethics committee? An exchange in @ClinTrialsJ.
#researchethics #steppedwedge #REC
3/ “Our main point is that researchers should not have to obtain ethics committee approval for the intervention when they have had no part in its design and implementation but only want to evaluate it prospectively…”
Read 15 tweets
Coronavirus Showed That America Wasn't Up to the Task - The Atlantic

theatlantic.com/ideas/archive/…
#America
Antibody testing will enhance the power and accuracy of COVID-19-prevention trials | Nature Medicine

nature.com/articles/s4159…
#testing #accuracy #trials #serological #antibody
Read 8 tweets
Randomization never ensures zero #confounding bias. It provides probabilistic bounds on confounding.

Therefore, by bad luck, the effect estimates from some perfectly conducted randomized #trials are substantially confounded. But we don't know which ones!

An eye-opening example:
In Denmark, 860 individuals were randomly allocated to either "intervention" or "control":
• No intervention was implemented
• Individuals were unaware of their allocation
• Mortality was higher in the intervention group with p=0.003

Keep this in mind when evaluating a trial.
Reference:
Vass M (PhD Thesis). Prevention of functional decline in older people. Faculty of Health Sciences, University of Copenhagen 2010, p.120.

Thanks to Mikkel Zöllner Ankarfeldt for bringing this example to my attention.
Read 7 tweets
Two new postdoc positions now open to work in our group at @CCDD_HSPH
@CCDD_HSPH One is on a cool new project to incorporate pathogen #sequence data in to analysis of #vaccine #efficacy #trials .
academicpositions.harvard.edu/postings/8296
Another on flexible topics including but not limited to #AMR (especially as it relates to #vaccines), dynamics of multistrain pathogens, or #vaccine #trial modeling academicpositions.harvard.edu/postings/8298
Read 3 tweets
Anyone who says “Z is an instrumental variable” doesn’t know what an instrumental variable is.

We can only say “Z is a proposed instrumental variable”, because we cannot ever verify that Z is an instrumental variable.

Not even in many randomized #trials.
journals.lww.com/epidem/fulltex…
Of the 3 instrumental conditions an IV must meet
(1) is empirically verifiable
(2) isn't verifiable, but expected in double-blind trials
(3) isn't verifiable, but expected in randomized trials

Thus #IVestimation will be biased in many #trials because condition (2) doesn't hold. Image
Though we can't verify that a variable is an IV, we can sometimes falsify that a variable is an IV. @MariaGlymour et al explain how
academic.oup.com/aje/article/17…

One would then expect all IV (eg, Mendelian randomization) studies try to falsify but, amazingly, most don’t. Malpractice.
Read 4 tweets
Jamie Robins and I argue @NEJM that (correct) per-protocol analyses are needed in pragmatic randomized #trials. bit.ly/2kqYZEI Image
@NEJM Demystifying intention-to-treat analyses of randomized #trials: The 1st step to embrace sound per-protocol analyses. bit.ly/2kqYZEI Image
@NEJM A simple rule for per-protocol analyses of #trials: Don't censor individuals who stop treatment for clinical reasons bit.ly/2kqYZEI Image
Read 3 tweets
Join us at #ACTStat Baltimore. I look forward to discussing methods for #perprotocol effects in randomized #trials bit.ly/2uPlGpZ
Because, remember, intention-to-treat analyses may not be conservative when comparing two active treatments… bit.ly/2uZP1hS Image
… and, in fact, intention-to-treat analyses may not be conservative even in #trials that compare active treatment vs. placebo Image
Read 3 tweets

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