Discover and read the best of Twitter Threads about #REINFECTION
Most recents (24)
The lies 2020:
Don’t Panic, we go for #herdimmunity, #children can’t spread it and won’t be harmed
What was really
#wewanttheminfected
And use #schools as a tap for controlled spread. No transparency, no testing no mask
Lets spread the lie that mask simply don’t work
Begin
Don’t Panic, we go for #herdimmunity, #children can’t spread it and won’t be harmed
What was really
#wewanttheminfected
And use #schools as a tap for controlled spread. No transparency, no testing no mask
Lets spread the lie that mask simply don’t work
Begin
Here #polarisation starts driven by misinformation and intransparancy by your government. Everybody could see that the measures were nog in line with urgency.
What were they hiding? Why no #zerorisk #zerocovid with borders closed. It could be done
2020: wait we know this will
What were they hiding? Why no #zerorisk #zerocovid with borders closed. It could be done
2020: wait we know this will
Lead to many many deaths but the #vaccin is almost here, working hard, we know the #SPIKE is a big thing, hold on #Hopium being built.
Meanwhile lets keep up the lie of children not important to monitor😢 we know from SARS they build less #antibodies lets presume they just not
Meanwhile lets keep up the lie of children not important to monitor😢 we know from SARS they build less #antibodies lets presume they just not
#covid #omicron #reinfection #丹麥 #再感染
關於再感染的丹麥研究引起了不少討論，先來重點摘要：
- 品質足以做分析是否為重複感染的檢體有限
- 該發表採集樣本時段在Delta浪潮末尾至Omicron BA.2浪潮開始
- 有BA.1-BA.2、BA.1-BA.1、BA.2-BA.2重複感染的案例
- 感染BA.1後可短期再感染BA.2
關於再感染的丹麥研究引起了不少討論，先來重點摘要：
- 品質足以做分析是否為重複感染的檢體有限
- 該發表採集樣本時段在Delta浪潮末尾至Omicron BA.2浪潮開始
- 有BA.1-BA.2、BA.1-BA.1、BA.2-BA.2重複感染的案例
- 感染BA.1後可短期再感染BA.2
這張是該發表的研究方法流程圖：
從指定時段內的1, 848, 466個確診案例
⬇️
找出1739例是間隔20~60天再度檢測出陽性
⬇️
將這些案例去做比對挑出1056個檢體去做定序分析
⬇️
分析過程中有433個檢體定序失敗
⬇️
263個案例可以做後續分析
要做再感染的檢驗分析難度其實很高，最後合格的樣本數並不多
從指定時段內的1, 848, 466個確診案例
⬇️
找出1739例是間隔20~60天再度檢測出陽性
⬇️
將這些案例去做比對挑出1056個檢體去做定序分析
⬇️
分析過程中有433個檢體定序失敗
⬇️
263個案例可以做後續分析
要做再感染的檢驗分析難度其實很高，最後合格的樣本數並不多
時空背景資訊：
該研究採集檢體的時間段2021年11月22日至2022年2月11日為Delta浪潮的末尾接到Omicron BA.1的大流行，再到Omicron BA.2開始崛起
這可以告訴我們什麼？
- 該時段內的再感染者一定非常多感染過Delta
- Omicron BA.2再感染BA.2者應該不多，因為剛崛起不久
該研究採集檢體的時間段2021年11月22日至2022年2月11日為Delta浪潮的末尾接到Omicron BA.1的大流行，再到Omicron BA.2開始崛起
這可以告訴我們什麼？
- 該時段內的再感染者一定非常多感染過Delta
- Omicron BA.2再感染BA.2者應該不多，因為剛崛起不久
2022 has brought new #Covid narrative -
1 #Virus getting weaker
2 #Vaccine situation fine as is
3 We don't need #publichealth measures any more
Really?
Some of my colleagues from academia, @WHO & @ApiJectCorp worked to put together this 🧵
#50CovidBeliefs
1 #Virus getting weaker
2 #Vaccine situation fine as is
3 We don't need #publichealth measures any more
Really?
Some of my colleagues from academia, @WHO & @ApiJectCorp worked to put together this 🧵
#50CovidBeliefs
Full pdf at injectionsafetyaccess.com/50-covid-belie…
Thx commenters & others fighting to get story right
@EricTopol @DrEricDing @JeremyFarrar @paimadhu @ashishkjha @ASlavitt @PeterHotez @rajpanjabi @globalhlthtwit @LawrenceGostin @Craig_A_Spencer @mvankerkhove @DrAbdiMahamud @krishna_u
Thx commenters & others fighting to get story right
@EricTopol @DrEricDing @JeremyFarrar @paimadhu @ashishkjha @ASlavitt @PeterHotez @rajpanjabi @globalhlthtwit @LawrenceGostin @Craig_A_Spencer @mvankerkhove @DrAbdiMahamud @krishna_u
& those fighting to get #COVID19 narrative right in #media-even harder!
@jriggers @rosafurneaux @iamandyhoffman @georgia_coan @megtirrell @paisleydodds @ButiniCecilia @KatherineEban @NPRMichel @yveyong @PostOpinions @latimesopinion @NPR
#50CovidBeliefs
injectionsafetyaccess.com/50-covid-belie…
@jriggers @rosafurneaux @iamandyhoffman @georgia_coan @megtirrell @paisleydodds @ButiniCecilia @KatherineEban @NPRMichel @yveyong @PostOpinions @latimesopinion @NPR
#50CovidBeliefs
injectionsafetyaccess.com/50-covid-belie…
#Reinfection in the #UK:
Reinfections for people with Prior Covid were rare until #Omicron arrived 1/
assets.publishing.service.gov.uk/government/upl…
Reinfections for people with Prior Covid were rare until #Omicron arrived 1/
assets.publishing.service.gov.uk/government/upl…
A newly dominant variant can reinfect only those who got infected with prior variants, but same-variant reinfection is extremely unlikely. This pattern seems to hold for ancestral variants & Delta 2/
A new @NatureMicrobial report: Despite a marked ⬇️ in NAbs over time, NAb responses persist for up to 480 d in most convalescents of symptomatic COVID19, whereas a high rate of undetectable NAb responses was found in those w/ asymptomatic infections 3/
nature.com/articles/s4156…
nature.com/articles/s4156…
Latest @WHO #TechnicalBrief on #Omicron
Overall risk remains very high & threat depends on
1⃣Transmissibility of #variant
2⃣How protective vaccines & prior infection are
3⃣Virulence of variant
4⃣Understanding of dynamics & uptake PHSM
Full 🧵👇 (1/)
who.int/publications/m…
Overall risk remains very high & threat depends on
1⃣Transmissibility of #variant
2⃣How protective vaccines & prior infection are
3⃣Virulence of variant
4⃣Understanding of dynamics & uptake PHSM
Full 🧵👇 (1/)
who.int/publications/m…
Daily Bookmarks to GAVNet 12/18/2021 greeneracresvaluenetwork.wordpress.com/2021/12/18/dai…
Why the Biden Presidency Feels Like Such a Disappointment
nytimes.com/2021/12/09/opi…
#PartisanPolitics, #CongressionalMajority, #MidTermElections, #FederalBudget
nytimes.com/2021/12/09/opi…
#PartisanPolitics, #CongressionalMajority, #MidTermElections, #FederalBudget
Why cannabis reeks of skunk
nature.com/articles/d4158…
#cannabis, #odor, #ChemicalCompounds, #sulphur, #ScientificDiscovery
nature.com/articles/d4158…
#cannabis, #odor, #ChemicalCompounds, #sulphur, #ScientificDiscovery
Daily Bookmarks to GAVNet 11/24/2021 greeneracresvaluenetwork.wordpress.com/2021/11/24/dai…
Alaska Issues Alert on Cloud of 109-Year-Old Ash
newser.com/story/313524/a…
#volcano #alaska #AshClouds #wind #geophysics
newser.com/story/313524/a…
#volcano #alaska #AshClouds #wind #geophysics
All-Turkic corridor heralds rise of new Eurasian political bloc
asia.nikkei.com/Business/Trans…
#PoliticalBlocs #eurasia #TransportationCorridors #BalanceOfPower #disruption
asia.nikkei.com/Business/Trans…
#PoliticalBlocs #eurasia #TransportationCorridors #BalanceOfPower #disruption
This tweet thread is about the #Covid_19: Updates from Singapore webinar on 26 Feb 2021
I've been busy so this is ~ a month after
It will be followed by a tweet thread documenting a more recent episode that was last week
I've been busy so this is ~ a month after
It will be followed by a tweet thread documenting a more recent episode that was last week
#Covid_19 : Updates from Singapore is a webinar organised by @WHOGOARN and @NUSMedicine
And moderated by @profdalefisher, Prof. David Allen, and Dr. Louisa Sun
And moderated by @profdalefisher, Prof. David Allen, and Dr. Louisa Sun
We are joined tonight by Dr. Peter Karim Ben Embarek
1) A Danish study @TheLancet has followed over 520 000 people, from the 1st to 2nd surge.
Similar to some other studies, they find that those with a prior #SARSCoV2 infection had ~80% lower risk of #reinfection, but only ~47% reduced in those ≥65 yrs
🧵
thelancet.com/journals/lance…
Similar to some other studies, they find that those with a prior #SARSCoV2 infection had ~80% lower risk of #reinfection, but only ~47% reduced in those ≥65 yrs
🧵
thelancet.com/journals/lance…
2) The @TheLancet article describes how Denmark during tested ~0.5 M people for #SARSCoV2 during wave 1.
At the end of 2020, ~10% of the population tested every week.
In all of 2020, Denmark tested ~4 million people (68% of their pop.) and 64% of those had been tested >1 time.
At the end of 2020, ~10% of the population tested every week.
In all of 2020, Denmark tested ~4 million people (68% of their pop.) and 64% of those had been tested >1 time.
3) In their analysis, they also included an alternative cohort, that looked at individuals throughout the pandemic (& not only those testing positive in the 1st & 2nd wave), thus examining reinfection risk in a group of 2.4 M people, of which 28 875 had been previously infected.
Meanwhile in #France,
"the peak of this second wave is over"
(according to the President in his Adress to the Nation):
"the peak of this second wave is over"
(according to the President in his Adress to the Nation):
Wait... "the peak is over" doesn´t mean "it´s back to normal"!
Confinement will only fall on December 15,
if there´s less than 5.000 new cases a day.
(today it´s ~9.000).
France is disappointed.🙁
Although they certainly can make it happen.
Confinement will only fall on December 15,
if there´s less than 5.000 new cases a day.
(today it´s ~9.000).
France is disappointed.🙁
Although they certainly can make it happen.
Meanwhile in #Switzerland:
(excess mortality of the second wave is significant)
Good news: fastest decrease in infections happens in the worst hit areas now.
(excess mortality of the second wave is significant)
Good news: fastest decrease in infections happens in the worst hit areas now.
‼️First #COVID19 death confirmed in a person *REINFECTED* with the #coronavirus.
Although other #SARSCoV2 reinfections have been confirmed, this is the 1st DEATH after reinfection known in the world.
<Thread>
#COVID19 #WearAMask
cnn.com/2020/10/13/eur…
Although other #SARSCoV2 reinfections have been confirmed, this is the 1st DEATH after reinfection known in the world.
<Thread>
#COVID19 #WearAMask
cnn.com/2020/10/13/eur…
The elderly woman had Waldenström's macroglobulinemia (rare blood cancer) & was receiving therapy to deplete B cells that make antibodies ("humoral immunity"). However, her T cells, which work to kill virus-infected cells (cell-mediated immunity), should NOT have been affected.🦠
The woman was initially admitted into hospital earlier this year with a severe cough + fever and tested positive for the #coronavirus. She was discharged 5 days later when "besides some persisting fatigue, her symptoms subsided completely."
#COVID19 #Reinfection
#COVID19 #Reinfection
#Coronavirus Reinfection:
🧬1st infection: April (symptomatic)
🧬2nd infection: June (symptomatic*)
*Required hospitalization, O₂
🧬Two virus genomes differed by 11 nucleotides
▪️Case A: 4 variants not in case B
▪️Case B: 7 variants not in case A
👉thelancet.com/journals/lanin…
🧬1st infection: April (symptomatic)
🧬2nd infection: June (symptomatic*)
*Required hospitalization, O₂
🧬Two virus genomes differed by 11 nucleotides
▪️Case A: 4 variants not in case B
▪️Case B: 7 variants not in case A
👉thelancet.com/journals/lanin…
SARS-CoV-2 #Reinfection:
🧬4 reversions to ref genome proves 2nd infection not tied to 1st infection
🧬2nd infection caused by new infection, not prolonged viral shedding
🧬Patient tested positive for IgM/IgG against SARS-CoV-2 nucleoprotein when hospitalized for 2nd infection
🧬4 reversions to ref genome proves 2nd infection not tied to 1st infection
🧬2nd infection caused by new infection, not prolonged viral shedding
🧬Patient tested positive for IgM/IgG against SARS-CoV-2 nucleoprotein when hospitalized for 2nd infection
4 Reversions:
🧬Calculate the probability that 4 variants in 1st infection (Case A) [that aren’t in 2nd infection (Case B)] mutated back to ref genome
🧬It’s the only way 1st infection could have mutated to become 2nd infection
🧬= ~1 chance in 10^18
🧬Odds exceedingly remote
🧬Calculate the probability that 4 variants in 1st infection (Case A) [that aren’t in 2nd infection (Case B)] mutated back to ref genome
🧬It’s the only way 1st infection could have mutated to become 2nd infection
🧬= ~1 chance in 10^18
🧬Odds exceedingly remote
(48) US #COVID19 Daily New Cases per 1M pop by State
in Descending Order, on September 27th, 2020
Courtesy of @Worldometers
in Descending Order, on September 27th, 2020
Courtesy of @Worldometers
(49) US #COVID19 Daily Deaths per 1M pop by State
in Descending Order on September 27th, 2020
Courtesy of @Worldometers
in Descending Order on September 27th, 2020
Courtesy of @Worldometers
First report of #COVID19 #reinfection from #India - two #asymptomatic health workers identified on routine #surveillance
academic.oup.com/cid/advance-ar…
#CSIRfightsCOVID19
academic.oup.com/cid/advance-ar…
#CSIRfightsCOVID19
#Genome sequencing of the #SARSCoV2 isolates from both the episodes suggest distinctly different virus , confirming reinfection.
Since the individuals were #asymptomatic during both episodes, and identified on regular #surveillance suggest asymptomatic #reinfections could be an under-reported entity. 2/2
#Coronavirus Reinfection:
🧬1st infection: March (symptomatic)
🧬2nd infection: August (asymptomatic)
🧬Two virus genomes differed by 24 nucleotides
🧬Proves that 2nd infection was not tied to 1st infection
🧬2nd infection caused by #reinfection, not prolonged viral shedding
🧬1st infection: March (symptomatic)
🧬2nd infection: August (asymptomatic)
🧬Two virus genomes differed by 24 nucleotides
🧬Proves that 2nd infection was not tied to 1st infection
🧬2nd infection caused by #reinfection, not prolonged viral shedding
Neutralizing Antibody:
🧬Tested NEGATIVE for IgG against SARS-CoV-2 nucleoprotein 10 days after symptom onset of 1st infection AND 1 day after hospitalization for 2nd infection
🧬Thus unknown if patient mounted neutralizing antibody response to 1st infection, didn’t last if yes
🧬Tested NEGATIVE for IgG against SARS-CoV-2 nucleoprotein 10 days after symptom onset of 1st infection AND 1 day after hospitalization for 2nd infection
🧬Thus unknown if patient mounted neutralizing antibody response to 1st infection, didn’t last if yes
#JustIn: #HKU's microbiology team issued a press release suggesting the 33-year-old IT patient, who came back from #Spain, is the world’s first #Covid19 reinfected patient.
#Covid19
#coronavirus
#Covid19
#coronavirus
From the #HKU report: Reinfection can occur just after a few months of recovery from the first infection. #SARS_CoV_2 may persist in the global population as is the case for other common-cold associated human coronaviruses, even if patients have acquired immunity.
Since the immunity can be short lasting after natural infection, vaccination should also be considered for those once infected person. Patients with previous #Covid19 infection should also comply with control measures such as masking and #socialdistancing.
Evidence is clear that people are not getting reinfected at least in the short term. CDC says there are no confirmed reports to date of a person being reinfected with COVID-19 within 3 months of initial infection.
#CovidVaccine @daniellevitt22 #SARSCoV2
researchgate.net/publication/34…
#CovidVaccine @daniellevitt22 #SARSCoV2
researchgate.net/publication/34…
Researchers are optimistic about the emerging data that says the human immune system will most likely fend off SARS-CoV-2 if exposed to the virus again. #covid19 #reinfection
Just now uploaded PDF on ResearchGate. Article covers all the latest evidence:
researchgate.net/publication/34…
Just now uploaded PDF on ResearchGate. Article covers all the latest evidence:
researchgate.net/publication/34…
Neutralizing IgG, Memory B/ T cells, #SARSCoV (T- cells after 17 yrs), Seattle Boat study (first direct human evidence), Karolinska Uni study, Common cold (cross memory #SARSCoV2), CDC controversy, ICMR. #covid19 @profshanecrotty @EricTopol @daniellevitt22
researchgate.net/publication/34…
researchgate.net/publication/34…
Special thread discussing #COVID19 reinfection evidence in Iran. I felt it is time to compile it in a separate thread from my daily ones.
/start
/start
First of all, what we have is just simply anecdotal evidence that is not confirmed by PCR.
What is shocking to me, is the horde of experts flat out rejecting these reports, saying there is NO PROOF for reinfection yet.
/pre1
What is shocking to me, is the horde of experts flat out rejecting these reports, saying there is NO PROOF for reinfection yet.
/pre1
Bear in mind in a binary case (reinfection vs no chance of reinfection) with grossly asymmetric risk profiles, burden of proof is for the side with less risk (no reinfection). That is just basic risk management.
/pre2
/pre2
As #COVID19 cases are found to spread, #Melbourne (city of ~5 million) tries to contain them by going into #Lockdown.
(The interview features the idea of a dedicated #Quarantine building - that would actually help, I guess)...
(The interview features the idea of a dedicated #Quarantine building - that would actually help, I guess)...
"People acting as if the pandemic was over was 'not the answer, it is part of the problem' ".
"The virus had leaked from postcodes already under the stay-at-home orders to other parts of #Melbourne."
(and beyond, it is feared).
"The virus had leaked from postcodes already under the stay-at-home orders to other parts of #Melbourne."
(and beyond, it is feared).
Due to #Melbourne's outbreak, neighbouring South Australia is about to completely close it's borders to #Victoria.
(Nearly) no exceptions. And those essential few who are allowed in, will have to wear facemasks the entire time...
(Nearly) no exceptions. And those essential few who are allowed in, will have to wear facemasks the entire time...
Vorpommern-Greifswald district (where rejections of #Gütersloh residents took place, yesterday)
has specific rules:
"Those who return from international risk areas (out of Germany) or whose Corona-Warning App has alerted them, need to report to authorites"
kreis-vg.de
has specific rules:
"Those who return from international risk areas (out of Germany) or whose Corona-Warning App has alerted them, need to report to authorites"
kreis-vg.de
In fact, Mecklenburg-Vorpommern's Corona-ordinance really prohibits entry of people from international risk areas AND german risk areas as well.
It's just not prominently featured on their websites.
(Overlooked that myself, hence deleted earlier tweet)
landesrecht-mv.de/jportal/portal…
It's just not prominently featured on their websites.
(Overlooked that myself, hence deleted earlier tweet)
landesrecht-mv.de/jportal/portal…
People from #Gütersloh district may have to scrap all their holiday plans anyway...
An official #Lockdown is just being announced for the entire district.
(for one week, as of now)
An official #Lockdown is just being announced for the entire district.
(for one week, as of now)
Thread on my #CovidDataProject: #ReOpenAmerica edition.
For those not familiar with my work, the original (and still primary) aim of my model was to answer the question, “Where would we be on #COVID19 deaths had @realDonaldTrump acted quickly and responsibly?” The answer is
1/x
For those not familiar with my work, the original (and still primary) aim of my model was to answer the question, “Where would we be on #COVID19 deaths had @realDonaldTrump acted quickly and responsibly?” The answer is
1/x
is shocking. As of midnight UTC last night, we stood at 72,271 deaths, and my model shows 90.905%, 65,698 American souls, would still be alive had he acted quickly. In other words, this would have been another tragic but relatively small blip on the epidemic radar, similar in
scale to the #SwineFlu under @BarackObama. And that’s without taking into account the added deaths globally, those caused by America’s failure to act.
Another, secondary goal has been predictive, looking at trends to make an educated guess about where we’re headed. That’s
3/x
Another, secondary goal has been predictive, looking at trends to make an educated guess about where we’re headed. That’s
3/x
Thoughts on upcoming #COVID19 #serology tests:
This is actually quite a challenge! (#Diagnostics often involve a lot of complexities). There is a lot of pressure to roll these tests out, but they need to perform well, or we do more harm than good. #MicroRounds (A thread)
This is actually quite a challenge! (#Diagnostics often involve a lot of complexities). There is a lot of pressure to roll these tests out, but they need to perform well, or we do more harm than good. #MicroRounds (A thread)
WHY we need these soon:
1. Contact tracing.
2. Can be used to test if a vaccine is working during a clinical trial (70 of them ongoing right now, I believe)
3. Inform public policy makers about rate of asymptomatic cases + previous infections/exposures =informed decision making
1. Contact tracing.
2. Can be used to test if a vaccine is working during a clinical trial (70 of them ongoing right now, I believe)
3. Inform public policy makers about rate of asymptomatic cases + previous infections/exposures =informed decision making
1/n A while back, there was some discussion on whether #COVID19 patients could get 're-infected'. The consensus opinion back then seemed that there were a few cases of those who had not fully recovered. Once you've got the antibodies, amirite? Only....
#Reinfection.
#Reinfection.
2/n Only, it looks like there have been actual confirmed cases #reinfection of #COVID19 in South Korea: 51. A very low rate of re-infection, but still a troubling question.
news.v.daum.net/v/202004061435…
news.v.daum.net/v/202004061435…
3/n To read that above article, click the A inside a rotating 'circle' in the symbols on the upper right-hand side of the page. You will get a drop-down set of symbols, as shown in the screencap below; choose your favored translation from that.
news.v.daum.net/v/202004061435…
news.v.daum.net/v/202004061435…
With the #COVID19 outbreak, it is important to use language responsibly. Here is the first entry of our new #ContagiousWords series, defining the buzzwords and terminology dominating today's conversation. #Pandemic #PandemicsCost
@ilariacapua Language is powerful, so we must be sure and accurate in the ways we communicate science. #Epidemic #ContagiousWords #COVID19
