Discover and read the best of Twitter Threads about #CARDIAC

Most recents (24)

1/

🎬 Now on stage Professor @giovannilandoni talking about what we DON'T KNOW about #cardiocirculatory drugs

#Norepineprhine is the most used vasoactive drug in the guidelines for:

🔹 #sepsis
🔹#cardiogenic shock❗(Scandinavian)

BUT...

@Smart_Meeting_M @SRAnesthesiaICU Image
2/

BUT... #Norepineprhine (base) does not exist❗

🚫 base is not soluble, unstable and unable to reach target receptors
💡 Let's make it a salt!
🤔 But which one?

⚠️ Available Norepineprhine salts has different #dilution
⚠️ Sometimes with misleading #labeling Image
3/

➡️ Please do not change you're clinical practice for this ⬅️

But consider the possible implications on:

🔹Second line drugs initiation
🔹Co- administration of other vasopressors
❗Comunication of your results!!!

pubmed.ncbi.nlm.nih.gov/36978126/

#FOAMed #FOAMcc Image
Read 8 tweets
1) Welcome to a new #accredited #tweetorial in our series of educational programs on #hypertrophic #cardiomyopathy #HCM. Previous programs, still available for 🆓CE/#CME, are at cardiometabolic-ce.com/category/hcm/.
Now you can earn another 0.75hr credit by following this 🧵!
2) Our expert author is JA Linderbaum MS, ARNP, FACC, FPCNA @jlinderbaum, Associate Professor of Medicine, @MayoClinic, CV #NursePractitioner, Assoc. Medical Editor #AskMayoExpert.
#FOAMed #MedEd @MedTweetorials #CardioTwitter @transformingHC @TNPJ_Journal #cardiology
3) This program is supported by an unrestricted educational grant from Bristol Myers-Squibb. Statement of accreditation and faculty disclosures at cardiometabolic-ce.com/disclosures/. Credit for #physicians #nursepractitioners #physicianassociates #nurses #pharmacists from @academiccme.
Read 70 tweets
Today's Twitter threads (a Twitter thread).

Inside: Excuseflation; and more!

Archived at: pluralistic.net/2023/03/11/pri…

#Pluralistic 1/ An old general store. Inste...
Excuseflation: Monopolists will never let a good emergency go to waste.

2/ Image
Hey look at this

* Letter from Daniel Ellsberg, diagnosed with terminal cancer ceasefire.ca/wp-content/upl… (h/t Gord Doctorow) 3/ Image
Read 20 tweets
Why the number of cases of #HeartAttack have increased significantly ?

A man died of #CardiacArrest during a Haldi ceremony at Kalapathar area.

A police constable Vishal (24) died, allegedly due to a #cardiac arrest during a workout at a gym in Bowenpally area.

#Hyderabad twitter.com/i/web/status/1…
A 19 yr old Muthyam died, reportedly of #CardiacArrest, collapsed while he was dancing in a wedding reception at Pardi K village in Kubeer mandal of #Nirmal dist.
He was shifted to the hospital where the doctor declared him brought dead.

#HeartAttack #heartattack2023
#Telangana
Another #HeartAttack,
A 38 yr old Shyam collapsed while playing badminton, in #Hyderabad.
In visuals people take turns to check if he is breathing, If life-saving #CPR had been administered early, he would have probably been alive.
Need awareness on CPR for all.
#cardiacarrest
Read 5 tweets
2/5 "#Uncanny #similarities with #amyloid-#disease associated #blood #coagulation and #fibrinolytic #disturbances together with #neurologic and #cardiac problems led us to investigate the #amyloidogenicity of the #SARSCoV2 #spike #protein (#S-protein)."
3/5 "#Amyloid #fibril #assays of peptide library mixtures and theoretical predictions identified seven #amyloidogenic #sequences within the S-protein."
Read 5 tweets
Empagliflozin is now my go-to SGLT2i for pts with #diabetes and #CKD or #CHF, over cana or dapa or ertu.

Why?

A: EMPA-KIDNEY: nejm.org/doi/full/10.10…
and EMPEROR-Reduced and EMPEROR-Preserved
1/
EMPA-KIDNEY is unique because it enrolled GFR 20-45 *without* proteinuria whereas others (DAPA CKD, CANVAS) enrolled pts with CKD+proteinuria, though DAPA-CKD conducted a subgroup analysis for UACR < and > 1000
The primary outcome was a composite of progression of #kidney disease (defined as #ESRD, a sustained decrease in eGFR to <10, a sustained decrease in eGFR of ≥40% from baseline, or death
from #renal causes) or death from #cardiovascular causes
Read 7 tweets
🧵 #LivingLongCovid

Some maybe already know me probably% and maybe my story.

I am a #HealthCareWorker and since before and at the beginning of #COVID19 I have worked in the #ICU saving lives and learning about #IntensiveCare

I've had #COVID19 3 times so far this pandemic.
I developed #LongCovid from my 2nd contagion that was serious at the time, I required hospitalization in #ICU and oxygen therapy.
Since Dec 2020 I have lived with #LongCovid since then and when I understood the Multi-organic gravity of #LongCovid
I SURVIVED!
And I still do it daily.

A few days ago I had a 2nd #InfarctionSilent a year ago I had a multiorgan failure accompanied by #infarctionSilente

We know that #COVID19 can cause #myocarditis and that is possibly the case, I don't know yet.

I tell you now.
Read 19 tweets
🚨911🧵Ive decided to randomly log medical calls in PDX.I’ve noticed a ⬆️ rate of Strokes, ♥️attacks / Cardiac issues, Falls / Dizziness, Loss of consciousness and Sudden deaths in younger than normal people. What has changed in the past 15 mo.’s that would cause this? 💉?
6/9/22
Portland medical calls:
7:45pm -8:43pm:: 9 month old baby- left side of body is limp, 12 year old with elevated heart rate & trouble breathing , two females have fallen and having a stroke. #VaccineSideEffects ? Is this normal? #VaccineDeaths ? 👂 to your local dispatch.
PDX 911 ⛑call 🧵
6/10/22
Time: 12:14pm-2:35pm
STROKE: 1
Chest pain / Cardiac: 3
Seizure: 1
Dizzy/Faint: 7
Sudden Leg pain: 2
Semi/ Unconscious: 6
DOA:
Read 20 tweets
1) Welcome to a new #accredited #tweetorial, Prevention and Management of Heart Failure in T2 Diabetes: The Diabetologist’s Perspective! Our expert author is Melanie J Davies CBE FMedSci @profmjdavies, Prof of Diabetes Medicine, U Leicester, Leicester Diabetes Unit @LDC_Tweets
2) This program is intended for #healthcare professionals and is accredited by @academiccme for 0.75h CE/#CME credit for #physicians #physicianassistants #nurses #nursepractitioners #pharmacists 🇺🇸🇨🇦🇬🇧🇪🇺. FOLLOW US for #cardiometabolic education from expert authors!
3) @cardiomet_CE is supported by educational grants from AstraZeneca, Bayer, Boehringer Ingelheim Pharmaceuticals Inc. and Eli Lilly Company, and Chiesi. See archived programs still available for credit at cardiometabolic-ce.com. Disclosures at cardiometabolic-ce.com/disclosures/
Read 43 tweets
So excited to finally share our paper, now available as a #bioRxiv preprint!

We found that enhancing #mtDNA replication can be highly deleterious, causing #Ferroptosis and neonatal 🫀#HeartDisease. 🧵thread coming soon..

biorxiv.org/content/10.110…

#newpublication #mitochondria
This project would not have been possible without the fantastic work from many people, so thank you all! @ASW_lab, @Kivela_lab, @WickstromLab, @JMitophile, @AWartiovaara et twitterless al.
@HelsinkiUniMed @helsinkiuni @HelsinkiUniMed @MitoResearch @uniofjyvaskyla @UniEastFinland
Recent years have brought several promising approaches to treat different kinds of #mitochondrial dysfunction, and increasing #mtDNA amount has been proposed to be beneficial for certain defects.
Read 11 tweets
How #sleep loss may make physical #exercise more challenging for the #heart:

We find that sleep loss ⬆️ the exercise 🚴‍♀️-induced ⬆️ in blood levels of a #cardiac stress biomarker vs. after normal sleep

But note, exercise is essential for your health
🧵->
sciencedirect.com/science/articl… Image
2/ Extensive epidemiological data has found that sleep impacts the risk of cardiovascular disease (CVD).

E.g. @uk_biobank (n~408k):

Vs. 7 h, sleep duration of ≤5 h & ≥9 h were associated with higher risk of CVD mortality & incidence (~+8-30%).

sciencedirect.com/science/articl…
3/ And elegant human experimental studies have shown that curtailed #sleep can adversely impact🫀physiology.

For instance, shortened sleep can ⬆️ #bloodpressure in humans, seen both after overnight wakefulness academic.oup.com/sleep/article/… & shortened sleep ahajournals.org/doi/abs/10.116….
Read 23 tweets
Update.

Deaths WITH #Covid19 age 0-19 yrs as of Jan 21 2022:

27

Reported/accepted #vaccine adverse events age 5-17 yrs (#Pfizer Comirnaty authorized Nov 19, 2021) as of Jan 14 2022 (56 days)

1,288

(w/ 291 categorized as serious in 12-17 yr old group)
#RegulatoryCapture

Prior to intro. of user fees in 1994, #HealthCanada was solely funded by tax dollars - therefore accountable to the public. By 2018, approx. 50% of #HealthCanada’s budget came from #Pharma. Quietly announced in Oct 2017 was intention to increase to 90%.
On May 27, 2021, Dr. Patrick Phillips was asked if the data in Canada's adverse event system can be trusted. He replied "absolutely not" & suggested #VAERS may be more reliable. However, "HHS’s own studies indicate that VAERS may be understating vaccine injuries by OVER 99%."
Read 12 tweets
#YesCCT : Clinical reporting & understanding finance by @docjuanb at #SCCT2021 . There are reimbursement challenges . #Cardiac CT is in the wrong Ambulatory Payment Classification (APC). Bill also must be supported by clinical symptom & diagnostic ICD10 codes. Not a “rule out”. ImageImageImageImage
Reimbursement tracks with the CPT used so use the right CPT code and make sure language in report supports that code. All CTA assumes 3D, thus need to mention 3D in report. Have your reporting align with @Heart_SCCT guidelines. @docjuanb at #SCCT2021 ImageImageImage
Unfortunately #cardiacCT often lumped into CT not cardiac. Hospitals should update cost charges to accurately reflect true cost of work, align w/ other cardiac testing. With costs underreported, CMS bases APC & reimbursement on these historically lower costs @docjuanb #SCCT2021 ImageImageImage
Read 4 tweets
This is a very late #WeekendLecture
but you can review it anytime you want😉
🧠#Aneurysm & #Subarachnoid Hemorrhage
Unruptured intracranial aneurysms are pathologic dilations at major branching brain arteries
~3% of adult population
nejm.org/doi/full/10.10…
thelancet.com/journals/lance… Image
#WeekendLecture
#Aneurysms & #SAH
The most common presentation of intracranial aneurysm is rupture leading to #SAH
The risk of rupture depends on patient and aneurysm related factor, ie: age/gender/location/size/growth, etc
🧠ahajournals.org/doi/10.1161/ST…
🧠journals.lww.com/continuum/Abst… Image
#WeekendLecture
#Aneurysms & #SAH
It is well known that endovascular or neurosurgical management of #unruptured intracranial aneurysm is not free of procedural #complications
This study investigates risk factors for this complications @JAMANeuro
👇
jamanetwork.com/journals/jaman… ImageImage
Read 10 tweets
#European_database #eudravigilance #adverse_effects #pfizer #date_03_04_2021
(underestimation due to delay of 90 days in reporting "not serious" events)
Individual cases for TOZINAMERAN= Pfizer is 127,789
#Italy is still at the lead with many more cases than other European countries ! Why is this?
Number of individual case by reaction group:
Detail of some reaction groups in following tweets
👇👇👇
Read 10 tweets
1/13 Really interesting read Rory. Thx for sharing. I agree, its v difficult to remain clear headed when theres so much data & it can all be interpreted in different ways. Prof. @AndrewEwing11 is unhappy with #Sweden's strategy and has been openly critical - he's entitled to that
2/13 I think that data is being represented in a way that suits the narrative.I added extra columns:"since Aug 7" & "since Sept 7".I used Oct 14 as end point (date of publication).I also highlighted Netherlands in red as it was best performing in the table and good for comparison
3/13 In Sweden from Aug to Oct there was a 3% increase in cumulative deaths per 100k and from Sept to Oct there was a 1% increase. Meanwhile, Netherlands (best of the worst) had 8% & 6% increases in cumulative deaths per 100k respectively.
Read 13 tweets
(1/22) Acute PE treatment. An ever evolving landscape.

How about a #tweetorial on acute pulmonary embolism (#PE) and how to use mechanical #thombectomy with @InariMedical #FlowTriever?? Lets goooooo!

#InariFellowsEdition #IRad #IC #cardiotwitter
Pic credit @Jonathan_PaulMD Image
2/ From @CDCgov data one American dies of a blood clot every....? #VTE #PE @PERTConsortium #InariFellowsForum
3/ Acute #PE stats

📊100,000–180,000 PE-related deaths annually in US

📊PE is the most preventable cause of death among hospitalized patients

📊3rd leading cardiovascular cause of death after coronary disease and stroke

⏱ 1 American dies of a blood clot every 6 seconds Image
Read 25 tweets
🤔, can B-type natriuretic peptide (BNP) & high-sensitive troponin I (hsTnI) improve the diagnosis of #cardiomyopathy & prognostication of major adverse #cardiac events (MACE) in people with #musculardystrophy?
academic.oup.com/ehjqcco/ehjqcc…
Heart disease is recognized as the leading cause of morbidity & mortality in patients with muscular dystrophy
This study prospectively followed 117 people (median age, 42 (interquartile range [IQR], 26-50) years; 49 [41.9%] women) with limb-girdle muscular dystrophy, type 1 myotonic dystrophy, or facioscapulohumeral muscular dystrophy.
Read 11 tweets
I want to talk about 2 papers that highlight the role of mitochondria in what are likely the progression of symptoms assoc with #COVID19. Note these papers are not about #covid but highlight important pathways. 1/
1st paper - Intracellular ATP is req. 4 #mitochondrial #apoptotic pathways rat #cardiac #myocytes ncbi.nlm.nih.gov/pubmed/12909326 2/
Key findings: apoptosis and necrosis are part of the same pathway, initiated by same mito sequences but are distinguished by time and severity, where the delimiting factor is available intracellular #ATP. 3/
Read 19 tweets
This is a MUST SEE video on the #Coronavirus in Italy. The #ICU intensivist explains the epidemic and treatment- Report From The Front Lines @JAMA_current - YouTube #Covid_19 #COVIDー19 #COVID
This is a good summary but somewhat inconsistent to what we have been hearing on #twitter about #italy. The question about triaging those sick and above 60 yo was NOT answered directly. He said the goal was for everyone to get an ICU bed but was that successful? 1/
There are many pictures of hazmat suits which is somewhat different and more aggressive than the reports we have been hearing about #coronavirus in Lombardy 2/
Read 19 tweets
For all those who ❤️for a “behind the scenes” #tweetorial on our BEST study: frontiersin.org/articles/10.33…
@CHeartsTrees @J_HarrisPT @BruceyMd @ProfJohnBuckley @lisacotie @DrAndrewPipe
The @HeartInstitute houses 1 of the largest #cardiac #rehabilitation programs in 🇨🇦. Even with our resources and infrastructure, we cannot accommodate cardiopulmonary exercise testing (CPET) to measure VO2peak for each and every patient before their 1st cardiac rehab class.
Even if we had sufficient personnel, training, equipment and resources, are expensive CPETs for the purpose of determining VO2peak and subsequent exercise prescription necessary?
Read 25 tweets
@onco_cardiology @JStojanovskaMD @MichaelCoMD @DmitryAbramovMD @chiarabd @HeartDocSubha @larsgrowo @SarjuGanatraMD @AnaBaracCardio @AkhilNarangMD @krychtiukmd @vass_vassiliou @DrToniyaSingh @AChoiHeart @AnkurKalraMD @adityadoc1 Incidence of Cardiac Metastases: 1.23%
Primary Cardiac Tumors 0.056%

Can be benign, malignant or pseudotumor
Primary Cardiac tumor- mostly benign

#Cardiac Mass eval: detailed clinical presentation, History, Physical Exam, #echofirst to see the tumor characteristics
Read 13 tweets
Team finds persistent pathogen Bartonella in a high proportion of #tumor tissue + nearby spleen/#cardiac tissue of dogs with HSA - a #cancer that arises from cells lining blood vessels☝️but did NOT find the pathogen in whole blood from the same dogs: journals.plos.org/plosone/articl… ImageImage
2/ Conclude 👉 “This work adds more evidence to the connection between #infection and cancer risk, and demonstrates that molecular testing of whole blood samples does not rule out the tissue presence of this pathogen [Bartonella]”: sciencedaily.com/releases/2020/… Image
3/ To be extra clear: this is an example of how the blood is often NOT a “sewer of the body” where #pathogens tied to chronic #disease can be found 👉 Rather pathogens in tissue, or in the CNS/brain, or even inside immune cells often require testing beyond blood to be identified
Read 3 tweets

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